What Is Pal-AHK (Topical)?
Pal-AHK is also known as Palmitoyl Tripeptide-3. It consists of amino acid sequences (alanine-histidine-lysine) attached to a Palmitoyl fatty acid molecule. The fatty-acid component of AHK makes it soluble in fat, which increases skin penetration and molecule absorption by skin cells.
Scientific research suggests that Pal-AHK may activate the production of fibroblasts by interacting with transforming growth factor-𝛽 (TGF-𝛽).
Molecular Formula: C31H56N6O5
Molecular Weight: 592.80 g/mol
Synonyms: Palmitoyl Tripeptide-3
The Research History of Pal-AHK
The Functions of Pal-AHK (Palmitoyl Tripeptide-3)
Research on animal models proves that Pal-AHK may enhance hair growth, fight off the effects of aging on the skin, and expedite wound healing. Pal-AHK’s studies in the cosmeceutical industry suggest that it may have the ability to enhance the production of collagen, tighten the skin, and accelerate the rate at which it regenerates.
Studies on animal models prove that Pal-AHK can activate the production of fibroblasts that will accelerate the production of extracellular matrix (ECM) in the skin. The extracellular matrix dominated by collagen and elastin also has several molecules embedded in it therefore; the increase in the extracellular matrix of the skin will result in an increase in collagen and elastin amounts in the skin. This, consequently, will give better skin appearance and strength.
Depth experiments suggest that Pal-AHK plays a significant role in the regulation of Vascular endothelial growth factor (VEGF) production. VEGF is a potent signaling molecule in the production of new blood vessels. Sequel to the ability of Pal-AHK to enhance the growth of blood vessels in the skin, it has shown improved skin regeneration and hair growth in animal models. The ability of Pal-AHK (Palmitoyl Tripeptide-3) to activate the production of VEGF allows for adequate blood supply to the skin. This, in turn, will result in supple and younger-looking skin.
VEGF functions can also be seen in diseases such as diabetes, cancer, and macular degeneration. It is an angiogenic factor that regulates angiogenesis by permitting endothelial cell proliferation, migration, and permeability. Thus, the ability of Pal-AHK to initiate the enhancement of VEGF production may help in the prevention of the prevalence of diabetes, cancer, and macular generation, as well as the prevention of disease in the cardiovascular system.
Due to the ability of Pal-AHK to boost the production of VEGF, wound healing is also accelerated. This is possible as a result of the deposition of collagen at the site of injury, angiogenesis, and epithelization. In the therapeutic environment, VEGF’s chemotactic, mitogenic, and permeability effects may be strong enough to promote repair and regeneration in non-healing wounds associated with artery occlusive disease and diabetes.
Scientific studies suggest that the ability of Pal-AHK to enhance the production of VEGF may also aid in bringing visual improvement to a modest degree—averaging about two lines of vision. This research proved that few patients regained full sight.
The Effects of Pal-AHK on Wrinkles and Hair Growth
Pal-AHK research on animal models has demonstrated the profound effects of Pal-AHK on wrinkles. AHK is a well-known stimulator of fibroblasts and has proven to be an enhancer of collagen synthesis in human skin cells in the laboratory. The addition of Palmitoyl to AHK shows enhanced AHK activities that are evident in skin penetration such as the penetration of cell membrane. This, in turn, will lead to increased levels of collagen synthesis and its overall effects.
Further research on animal models suggests that Pal-AHK can reduce and inhibit the prevalence of fine lines and wrinkles, limit the occurrence of age-related spots, including skin tone, improve texture and improve skin smoothness.
Research also shows that Pal-AHK plays a role in reducing oxidative stress (free-radical attack) and increasing hair growth by the dermal cells of the papilla. Its ability to reduce oxidative stress stimulates elevated DHT formation in scalp follicles. AHK complex inhibits oxidative stress by enhancing the production of Superoxide dismutase (SOD), this, in turn, neutralizes the potent free-radical superoxide.
The addition of palmitoyl to the peptide sequence improves the aforementioned effects of AHK.
The Side Effects of Pal-AHK
While Pal-AHK has numerous advantages, long-term administration may result in VEGF hypersecretion into the bloodstream. This, in turn, can lead to arterial thromboembolic events such as:
• Myocardial Infarction
• Gastrointestinal Perforations
• Kidney diseases
• Bowel Perforation
• Reversible Posterior Leukoencephalopathy Syndrome
• Wound Complications
Pal-AHK (Palmitoyl Tripeptide-3) functions to enhance hair growth, fight off the effects of aging on the skin and expedite wound healing. Advanced research in cosmeceuticals proves that they can function to tighten the skin, enhance the production of collagen and accelerate the rate at which it regenerates. The functions of Pal-AHK are numerous. However, this peptide is for educational and scientific studies, not for human use or consumption.