Pal-GHK (Palmitoyl Tripeptide-1) (Topical) (200mg)

Pal-GHK (Palmitoyl Tripeptide-1) (Topical) Peptide

Pal-GHK, also known as Palmitoyl Tripeptide-1 and Palmitoyl Oligopeptide, is a synthetic peptide developed to function in protein production to support the skin’s extracellular matrix (ECM),  and skin pigmentation. Pal-GHK is a synthetic hybrid peptide with one fatty acid and one peptide. “Pal” represents Palmitoyl—the covalent attachment of fatty acid to the end of the structure. “GHK” represents glycine-histidine-lysine—the peptides synthetic structure. Pal-GHK is a small fraction of the large elastin protein and may be a powerful stimulant of fibroblasts—cells responsible for synthesizing collagen, elastin, and other proteins in the skin’s extracellular matrix, bones, and connective tissues.

Pal-GHK is still under scientific review to further discern its potential to improve collagen synthesis and enhance the development of blood vessels.^[1]

Specifications

Sequence: Palmitoyl-Gly-His-Lys

Molecular Formula: C₃₀H₅₄N₆O₅

Molecular Weight: 578.8 g/mol

Synonyms: Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide

Pal-GHK Research

The Primary Function of Pal-GHK
Pal-GHK consists of a palmitic acid residue molecule attached to a fraction of the elastin protein. This fraction of the elastin protein consists of glycine, histidine, and lysine—collectively called GHK. According to research in animal models, GHK has been suggested by researchers to potentially stimulate the growth and reproduction of fibroblasts. Research is ongoing to determine GHK’s ability to enhance skin structure and permeability, resilience, and texture through animal research models. The attachment of the Palmitoyl molecule may support the peptide’s functions. There is ongoing research to determine Palmitoyl’s role in supporting cell penetration in animal models—a characteristic that might make Palmitoyl a desirable ancillary component to the GHK molecule.

The GHK molecule in Pal-GHK appears to trick fibroblasts into registering elastin protein damage. Consequently, the fibroblasts will grow and proliferate to regenerate and renew the damaged elastin. Aging animals’ fibroblasts tend to lose their activity and become dormant. Scientific studies suggest that fibroblasts may rejuvenate and reduce the consequences of cell dormancy through exposure to GHK.^[2] The research concludes that there is “biological data demonstrating positive effects of GHK in skin and proposes interaction with antioxidant-related genes as a possible explanation of its antioxidant activity.” The palmitoyl molecule of the Pal-GHK may serve as an effective transport complex.

Pal-GHK has been suggested by researchers to function to stimulate genes that reset cells. The attachment of Pal to the peptide sequence GHK, may support the peptide in the stimulation of DNA repair genes and the enhancement of the expression of the 14 genes that regulate antioxidant production. These genetic modifications may potentially remove radicals and toxic agents, which are considered responsible for the prevalence of age-related diseases.

Before research in Pal-GHK’s potential for inducing the production of fibroblasts, Pal-GHK was an researched for its possible antioxidant characteristics. Along the way, researchers posited that the peptide molecule may also potentially mitigate the prevalence of neurodegeneration, such as Alzheimer’s Disease and other age-related issues. Research into the peptide has unveiled numerous possible hypotheses for the peptide’s mechanism of action. Pal-GHK appears to allow for the production of new blood vessels at sites of injury. It may also support nerve repair and growth of new nerves. Pal-GHK also appears to improve the actions of genes that aid healing—stimulating DNA repair genes while suppressing the gene responsible for cancer growth. Pal-GHK may also function to activate DNA repair genes and healing genes that become silent with age. Ongoing research suggests that Pal-GHK may aid the regeneration of damaged hair follicles.

Pal-GHK and Wrinkles, Skin Strength
Research in animal models suggests that Pal-GHK may protect the skin’s extracellular matrix by inducing the endogenous production of certain essential proteins, such as collagen and elastin.^[3] Pal-GHK also appears to replace the extracellular skin matrix—resulting in wrinkle reduction, firmer skin structure, and improved surface texture while preventing the disintegration of collagen following exposure to UVA light.^[4] Lip and mouth moisture retention was observed as well. The scientists conclude that “The results from this clinical study demonstrate that this two-part lip-care treatment product was well tolerated and effective in restoring moisture and fullness to the lips of female subjects with mild-to-moderate lip dryness.” When attached to short peptides, Pal-GHK appears to act cooperatively to reduce the prevalence of skin wrinkling. Pal-GHK has also been suggested to be helpful in reducing redness and discolored skin following photodamage (malesma) in animal models.^[5]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

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