What Is Pal-GHK (Palmitoyl Tripeptide-1) (Topical)?
Pal-GHK, also known as Palmitoyl Tripeptide-1 and Palmitoyl Oligopeptide, is a synthetic peptide whose functions are evident in collagen, skin pigment, and skin health. Pal-GHK is immensely useful in improving skin health and reversing the obvious signs of aging.
Pal-GHK is a synthetic hybrid peptide with one fatty acid and one peptide. The Pal-end represents Palmitoyl—the fatty acid end. Meanwhile, the GHK-end represents glycine-histidine-lysine—the peptide end. Pal-GHK is a small fraction of the large elastin protein and a powerful stimulant of fibroblasts—cells responsible for synthesizing collagen, elastin, and other proteins in the skin’s extracellular matrix, bones, and connective tissues.
Pal-GHK is still under scientific review to further discern its ability to improve collagen synthesis and enhance the development of blood vessels.
Molecular Formula: C30H54N6O5
Molecular Weight: 578.8 g/mol
PubChem: CID 10231864
Synonyms: Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide
Pal-GHK (Palmitoyl Tripeptide-1) Research
The Primary Function of Pal-GHK
Pal-GHK consists of a palmitic acid residue molecule attached to a fraction of the elastin protein. This fraction of the elastin protein consists of Glycine, histidine, and lysine—collectively called GHK. According to research in animal models, GHK stimulates the growth and reproduction of fibroblasts, making it become one of the peptides of interest due to its functions in wound healing, tissue regeneration, and skin repair.
Research is ongoing to determine GHK’s ability to enhance skin strength, resilience, and smoothness in animal models. Although GHK is responsible for most of these effects, the palmitoyl molecule makes it even more potent. There is ongoing research to determine palmitoyl’s role in boosting skin and cell penetration in animal models—a feature that could make palmitoyl a vital ancillary in creams and topical ointments in both the medical and cosmetic fields.
The GHK molecule in Pal-GHK tricks fibroblasts into thinking there is elastin protein damage. Consequently, the fibroblasts will grow and proliferate in the quest to regenerate and renew the elastin in the skin they think is lost. Aging animals’ fibroblasts tend to lose their activity and become dormant. Scientific studies prove that fibroblasts may rejuvenate and reduce the effects of aging on the skin.
The palmitoyl molecule of the Pal-GHK serves as a transport complex. Its attachment to GHK guarantees increased skin and cell penetration in animal models. In general, Pal functions to get GHK to where it is most needed—in the cells within the skin.
Pal-GHK functions to stimulate genes that specifically reset cells to a healthier and younger state. The attachment of Pal to the peptide sequence—GHK, makes it overly potent in the stimulation of DNA repair genes and the enhancement of the expression of the 14 genes that regulate antioxidant production. These genetic modifications may reduce the effects of aging and remove radicals and toxic agents responsible for the prevalence of age-related diseases.
Before Pal-GHK’s function in inducing the production of fibroblasts, Pal-GHK was an excellent antioxidant. It helps to prevent the prevalence of Alzheimer’s Disease and other age-related issues. Pal-GHK helps in allowing for the production of new blood vessels at sites of injury (it aids in rapid healing). It helps in nerve repair and also in the growth of new nerves. Pal-GHK improves the actions of genes that aid healing—stimulates DNA repair genes while suppressing the gene responsible for cancer growth. Pal-GHK can also function to activate DNA repair genes and healing genes that become silent with age.
Ongoing research suggests that Pal-GHK may aid the regeneration of lost hair.
The Role of Pal-GHK in Reducing Wrinkles and Strengthening the Skin
Research in animal models shows that Pal-GHK can protect the skin from several effects of aging. Research in animal models suggests that Pal-GHk can improve collagen and elastin production. Pal-GHK also replaces the extracellular skin matrix—resulting in wrinkle reduction, firm skin, and improved rough skin while preventing the disintegration of collagen following exposure to UVA light.
Pal-GHK proves helpful in the restoration of lip moisture and fullness in animal models. When attached to short peptides, Pal-GHK can act cooperatively to reduce the prevalence of fine lines and wrinkles. Pal-GHK has also proven helpful in reducing redness and discolored skin following photodamage (Malesma) in animal models.
Pal-GHK—Palmitoyl Tripeptide-1 is a synthetic hybrid peptide that functions to improve the synthesis of collagen, elastin, and other proteins in the extracellular matrix of the skin, bones, and connective tissues. Its functions are not limited as it also boosts the growth and regeneration of fibroblasts. This, in turn, would increase the formation of blood vessels.
Pal-GHK has yet to be connected with any discernible adverse effects. Nevertheless, this peptide is a research peptide limited to educational and scientific purposes, not for human use or consumption.