Pal-GHK (Palmitoyl Tripeptide-1) (Topical) (200mg)

What is the Pal-GHK (Palmitoyl Tripeptide-1) (Topical) peptide?

Pal-GHK, also known as Palmitoyl Tripeptide-1 and Palmitoyl Oligopeptide, is a synthetic peptide developed to function in collagen production, skin pigmentation, and skin health. Pal-GHK may be immensely useful in improving skin health and reversing the obvious signs of aging. Pal-GHK is a synthetic hybrid peptide with one fatty acid and one peptide. “Pal” represents Palmitoyl—the fatty acid end. “GHK” represents glycine-histidine-lysine—the peptide end. Pal-GHK is a small fraction of the large elastin protein and may be a powerful stimulant of fibroblasts—cells responsible for synthesizing collagen, elastin, and other proteins in the skin’s extracellular matrix, bones, and connective tissues.
Pal-GHK is still under scientific review to further discern its potential to improve collagen synthesis and enhance the development of blood vessels.^[1]

Specifications

Sequence: Palmitoyl-Gly-His-Lys

Molecular Formula: C30H54N6O5

Molecular Weight: 578.8 g/mol

PubChem: CID 10231864

Synonyms: Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide

Reconstitution: Required

Pal-GHK Research

The Primary Function of Pal-GHK
Pal-GHK consists of a palmitic acid residue molecule attached to a fraction of the elastin protein. This fraction of the elastin protein consists of Glycine, histidine, and lysine—collectively called GHK. According to research in animal models, GHK may stimulate the growth and reproduction of fibroblasts, supporting it to become a primary peptide of interest due to its potential in wound healing, tissue regeneration, and skin repair. Research is ongoing to determine GHK’s ability to enhance skin strength, resilience, and smoothness in animal models. Although GHK appears to be responsible for most of these effects, the Palmitoyl molecule may make its functions even more potent. There is ongoing research to determine Palmitoyl’s role in boosting skin and cell penetration in animal models—a feature that could make Palmitoyl a vital ancillary in creams and topical ointments in both the medical and cosmetic fields.

The GHK molecule in Pal-GHK appears to trick fibroblasts into thinking there is elastin protein damage. Consequently, the fibroblasts will grow and proliferate in the quest to regenerate and renew the elastin in the skin they think is lost. Aging animals’ fibroblasts tend to lose their activity and become dormant. Scientific studies suggest that fibroblasts may rejuvenate and reduce the effects of aging on the skin.^[2] The research concludes that there is “biological data demonstrating positive effects of GHK in skin and proposes interaction with antioxidant-related genes as a possible explanation of its antioxidant activity.” The palmitoyl molecule of the Pal-GHK may serve as a transport complex. Its attachment to GHK appears to increase skin and cell penetration in animal models. In general, Pal may be characterized as a transport to get GHK to where it is most needed—in the cells within the skin.

Pal-GHK may function to stimulate genes that specifically reset cells to a healthier and younger state. The attachment of Pal to the peptide sequence GHK, may make it overly potent in the stimulation of DNA repair genes and the enhancement of the expression of the 14 genes that regulate antioxidant production. These genetic modifications may reduce the effects of aging and remove radicals and toxic agents responsible for the prevalence of age-related diseases.

Before research in Pal-GHK’s potential for inducing the production of fibroblasts, Pal-GHK was an researched for its possible antioxidant properties. It may also help to prevent the prevalence of Alzheimer’s Disease and other age-related issues. Pal-GHK appears to help in allowing for the production of new blood vessels at sites of injury (aiding in rapid healing). It may help in nerve repair and also in the growth of new nerves. Pal-GHK also appears to improve the actions of genes that aid healing—stimulating DNA repair genes while suppressing the gene responsible for cancer growth. Pal-GHK may also function to activate DNA repair genes and healing genes that become silent with age.
Ongoing research suggests that Pal-GHK may aid the regeneration of lost hair.

Pal-GHK and Wrinkles, Skin Strength
Research in animal models suggests that Pal-GHK may protect the skin from several effects of aging. Research in animal models suggests that Pal-GHk can improve collagen and elastin production.^[3] Pal-GHK also appears to replace the extracellular skin matrix—resulting in wrinkle reduction, firm skin, and improved rough skin while preventing the disintegration of collagen following exposure to UVA light. Pal-GHK may prove helpful in the restoration of lip moisture and fullness in animal models.^[4] The scientists conclude that “The results from this clinical study demonstrate that this two-part lip-care treatment product was well tolerated and effective in restoring moisture and fullness to the lips of female subjects with mild-to-moderate lip dryness.” When attached to short peptides, Pal-GHK appears to act cooperatively to reduce the prevalence of fine lines and wrinkles. Pal-GHK has also been suggested to be helpful in reducing redness and discolored skin following photodamage (Malesma) in animal models.^[5]

Conclusion

Pal-GHK—Palmitoyl Tripeptide-1 is a synthetic hybrid peptide that may function to improve the synthesis of collagen, elastin, and other proteins in the extracellular matrix of the skin, bones, and connective tissues. Its functions are not limited as it also has been researched for its potential to boost the growth and regeneration of fibroblasts. This, in turn, may increase the formation of blood vessels. Pal-GHK has yet to be connected with any discernible adverse effects. Nevertheless, this peptide is a research peptide limited to educational and scientific purposes, not for human use or consumption.

References