PE-22-28 (8mg)

(29 customer reviews)


Discount per Quantity

5 - 95%$46.55
10 +10%$44.10
SKU: PE-22-28-8mg Category:


What Is PE-22-28 Peptide?

PE-22-28 is a synthetic variant of the naturally occurring peptide spadin. Spadin is a secreted peptide obtained from sortilin. It acts as an antagonist of the TREK-1 (TWIK-related-potassium channel) receptor, a two-pore potassium channel identified as a potential target in treating depression and as a possible neurogenic regulator. Studies in mice have shown that TREK-1 receptor deletion makes them resistant to depression. Sortilin treatment also leads to resistance to depression by promoting neuronal growth and intersynaptic connections.
PE-22-28 represents the group of synthetic spadin analogs with higher efficacy and stability than spaldin.
Neurogenesis is a long-term consequence of consuming anti-depressant medications (e.g., SSRIs). Neuronal growth indicates the efficacy of anti-depressants. PE-22-28 is faster than any known anti-depressant and induces neurogenesis after just four days. The peptide can treat neurodegenerative diseases, stroke, and boost memory.
TREK-1 is found in various tissues such as the brain, heart, smooth muscle, and the pancreas. It also plays an important role in pain perception, anesthesia, and neuroprotection.


AKA: Spadin Analog, PE2228, TREK-1 Antagonist, PE 22 28, Sortilin Derivative, PE 2228

Sequence: GVSWGLR

Molecular Formula: C35H55N11O9

Molecular Weight: 773.8947 g/mol

Reconstitution: Required

PE-22-28 Research

What Is TREK-1?
It is the cognate receptor for spadin and thus PE-22-28 primarily. It is a two-pore potassium channel regulated by several different molecules and regulates neuronal excitability. TREK-1 is abundant in the prefrontal cortex, the amygdala, and the hippocampus. By reducing the neuron’s excitability, TREK-1 can help protect against excitotoxicity.

PE-22-28 is more effective in reversing depression than any currently used treatment and with fewer side effects. It has been shown to relieve depression in just four days without producing any side effects on other functions that are controlled by the TREK-1 channel.
PE-22-28 reverses the loss of hippocampal volume by stimulating neurogenesis and thus helps fight depression.
The peptide does not show any significant side effects which are commonly associated with anti-depressant medication. Current treatments for depression have a host of known side effects ranging from suicidality to libido changes and cognition problems. PE-22-28 promotes neurogenesis without triggering these side effects.

Post-Stroke Depression
Post-stroke depression (PSD) is a common symptom of post-brain ischemia and affects standard treatment caused by TREK-1 overexpression. In mouse model experiments, this upregulation can be suppressed or reversed using both SSRI anti-depressants as well as TREK-1 blockers like spadin.

PE-22-28 promotes neurogenesis but in a shorter duration of time. Studies in mice reveal that PE-22-28 increases neurogenesis and synaptogenesis after four days.
CREB (cAMP response element-binding protein) is a transcription factor associated with neuronal plasticity, memory formation, and the development of spatial memory. CREB appears to be a necessary component in not just the growth of neurons but also in their protection.
It has been demonstrated in animal models that removing the TREK-1 channel is a recipe for disaster. In previous mouse models, knockout of TREK-1 increased the likelihood of seizure activity significantly and reduced the normal ability of this two-pore potassium channel to protect neurons from excitotoxicity. It came as a bit of surprise then that neither spadin nor PE-22-28 enhanced seizure activity. Even more interesting is the fact that mice treated with spadin are more resistant to developing generalized seizures. PE-22-28 has even more profound protective effects than spadin.

Muscle Function
There is some research to suggest that TREK-1 plays an important role in the ability of a muscle to respond to mechanical stimulation. In particular, TREK-1 blockade appears to increase contractility in muscle tissue, while activation of the channel appears to promote muscle relaxation. While this particular aspect of the TREK-1 channel is still in the early stages of the investigation, it is becoming increasingly important. There is hope that understanding the role of molecules like PE-22-28 in muscle contraction and relaxation may provide new treatment modalities for conditions like myogenic bladder dysfunction and may also open up new pathways for understanding the physiology of muscle performance.

PE-22-28 is an effective treatment for depression and a potent stimulator of neurogenesis and synaptogenesis in the hippocampus. It has far fewer side effects than existing anti-depressant medications. It appears to retain much of its ability to antagonize TREK-1 even after modifications that boost half-life or alter the route of administration. In short, PE-22-28 thus provides a strong target for guiding the development of a new generation of anti-depressants and is helping to shed light on the burgeoning field of nootropics. It is also helping to expand the arsenal of medications used to treat neurodegenerative diseases like Alzheimer’s disease.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

29 reviews for PE-22-28 (8mg)

  1. Jess Reeves

    empresa confiable

  2. Liam Coleman

    They holding up their own. Can’t go wrong with their peptides

  3. Susan Onuoha

    The service was excellent, and the price was reasonable compared to others!

  4. Shane Ramirez

    Exceptional customer service, particularly in the area of advice. Delivered on time. Was refereed here by a friend. Ty

  5. Mickael Dobre

    I’m certain these peptides are of the highest grade. Thank you for the professionalism.

  6. Michael Yong

    I wish there were more peptides with topical application in your range, but besides that, the overall quality of the products I’ve ordered is top-notch

  7. Genesis Ashley

    You can really tell they care about being a good and reliable business for their customers. I actually ENJOY calling to fix a problem cause I know it’ll be fixed the first time around and quickly!!!!!

  8. Melanie Cruz

    I think you guys would really benefit from adding more topical peptides to your range

  9. Roy Davis

    Very appreciative of the bacteriostatic water that comes free with some products. Very helpful

  10. Yu-jung Lin

    Không có vấn đề với hải quan, sản phẩm tinh khiết và thật

  11. Joshue Salmon

    Been with them since May. Had a few products come in that were broken. Vials and even the topical container were broken. I emailed with Taylor and within 15 minutes I had a new tracking number for a new shipment.

  12. Elie White

    Got all my peptides in quickly and in good condition.

  13. Wendy Fields

    They are very professional and a credible company. Have no issues with the quality of the peptides or billing.

  14. Hudson H.

    Noticed they have really fast shipping! Even when you pay for the standard type maybe its the carrier but I got everything faster than expected.

  15. Gabriel Miller

    They sell whats advertised and thats good quality peptides!

  16. Jon Harper

    Highly recommened reaching out to them via phone for efficient and fast service.

  17. Noah White

    Have great peptides. Been noticing a difference in my results, small but noticable.

  18. bobby jones

    Very user-friendly site

  19. Emmet Downing

    This is the most effective peptide I have found for my projects!

  20. Stephan P

    After four orders, I can confidently say that the quality is consistent. So far, I have not been disappointed.

  21. Han patel

    As soon as I realized anything was amiss with my payment, Danny got in touch with me. Because I didn’t have access to a computer at the time, they collected my money over the phone, which was convenient.

  22. John lee

    I never experienced any of the problems mentioned in other reviews. In my opinion everything is safe and trustworthy

  23. Sam reyes

    Company is great, I recommend them to anyone asking about a reliable peptide seller.

  24. David Loftin

    Any questions you might have they have the answers. They are always prepared and have well-trained employees who know everything about the peptides

  25. Carson Ellsworth

    Amazingly fast delivery

  26. Kody Jackson

    I have been searching for this product for a while now and it is very hard to find. BP has an amazing pp selection to choose from

  27. Phil Morton

    Had a lovely experience with Danny this morning. Danny was able to help with a credit card issue I was having. The site kept rejecting my payment option even though it’s listed that they accept it (Visa). After some frustration and more attempts I E-mailed them about the issue. Danny responded fairly quickly and worked to help figure out what the issue was. After a few more email’s he was able to get someone to fix the issue and I got my order in. Their IT guy told him there was some sort of error or problem going on with their site but first time I’ve experienced that.

  28. Rick Dawson

    Got research-worthy results by using this product. Highly recommend

  29. Vince Vanderlinden

    I have been researching depression for years now and the results I get from testing this peptide are very promising. Will definitely consider keeping BP as my top 3 peptide suppliers

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