Pinealon (20mg)

(26 customer reviews)


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What Is Pinealon Peptide?

Pinealon is a short peptide comprising only three amino acids. It is one of the few synthetic peptides considered peptide bioregulators as they interact directly with DNA to alter gene expression levels. It causes behavior modification and protects various cell types, including neurons against hypoxia. Pinealon directly affects the pineal gland to address issues with medication metabolism, circadian rhythm disorders, memory, learning, and more.
Pinealon Interacts Directly with DNA
Pinealon, unlike most other peptides, does not bind to the cell surface or cytoplasmic receptors. Testing in cell cultures (HeLa cells) has proven that the peptide penetrates the cell membrane directly, and the nuclear membrane interacts with DNA. Thus it acts as a regulator of gene expression and mediates myriad cellular effects.


AKA: Glutamylaspartylarginine, T-33 peptide

Sequence: Glu-Asp-Arg

Molecular Formula: C15H26N6O8

Molecular Weight: 418.407 g/mol

PubChem: 18220191

Reconstitution: Required

Pinealon Research

Pinealon Research and Aging
Pinealon may have anti-aging effects on the central nervous system. It is anabolic in the brain and reduces the rate of aging when examined by biological age indicators.
Pinealon influences other tissues, such as muscles, by altering irisin expression. Irisin protects muscle cells during exercise, enhances fat burning, and triggers telomere elongation. The peptide thus protects telomere and helps overcome the effects of aging and oxidative stress. Interestingly, irisin being active outside muscles, pinealon can regulate aging all over our body.

Pinealon Research and Neuron Protection
Pinealon was observed to protect neurons against oxidative stress in rats, enhancing cognitive function and motor coordination. The study showed a significant reduction in both reactive oxygen species accumulation and necrotic cells in animal brains.
The peptide thus activates proliferation pathways to modify the cell cycle as part of its protection against cell death. Under oxidative stress, this effect controls the damaging effects of reactive oxygen species.
It also increases the resistance of neurons to hypoxic stress through activation of innate anti-oxidative enzyme systems and reducing the excitotoxic effects of N-methyl-D-aspartate (NMDA). N-methyl-D-aspartate (NMDA) is an amino acid derivative that can be neurotoxic.
Irisin levels in the central nervous system induce genes in the hippocampus that are important to memory, learning, and overall neuron health. Exercise directly improves levels of irisin in the brain, thus associating physical activity and cognition.

Pinealon research and depression
The peptide can promote the expression of 5-tryptophan hydroxylase via epigenetic changes in brain cortex cells. 5-tryptophan hydroxylase is crucial for the production and secretion of serotonin. This peptide shows neuroprotective and geroprotective features and is the most common target of anti-depressive medications called selective-serotonin reuptake inhibitors (SSRIs). Pinealon thus provides a healthier alternative to boost serotonin compared to SSRIs.

Pinealon Protects Cells from Caspase-3 and Cell Death
The peptide alters cytokine signaling that causes an increase in levels of the caspase-3 enzyme. Caspase-3 is directly initiating apoptosis through genetic instruction. By regulating caspase-3, pinealon blocks at least one pathway to cell death and thereby controls the effects of oxygen deprivation during a stroke. The peptide can reduce caspase-3 levels following myocardial infarction. The short peptide may have applications in treating heart attacks and controlling the long-term remodeling that causes dysfunction following myocardial infarction.
It also promotes cell proliferation in young and old animals by blocking apoptosis in skin cells. This increases the regenerative process and offsets age-related pathology in the skin. Pinealon may eventually form part of a multi-faceted approach to wound healing and could apply everything from sun protection to serious burn treatment.

Pinealon Research and Sleep Regulation
It does not come as a surprise that pinealon affects both the sleep-wake cycle and sleep behavior. Research indicates that pinealon may help control the dysfunction caused by shift work and other activities (e.g., long-distance travel) that interfere with normal sleep patterns. The peptide appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, improving sleep, depression, mood, blood pressure, etc.
The ability to regulate sleep is associated strongly with rates of aging. Disturbed sleep is extremely hazardous to the body and affects cognition, cardiac health, wound healing, mood, and more. Pinealon may help reduce the impact of sleep disturbance and thereby offset its effects on aging. This could be beneficial to those forced into disorder sleep due to their jobs and individuals suffering from an organic disease that impacts sleep-wake cycles.
Pinealon exhibits minimal side effects and low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice is not equivalent to humans.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

26 reviews for Pinealon (20mg)

  1. Zayn Atkinson

    Outstanding!!! Love their peptides.

  2. Khaled Hadid

    Pleased customer here. I made a mistake selecting a delivery option and they covered Saturday delivery free.

  3. Jasper Hall

    First purchase with these guys. So far so good, decently priced and products arrived when they said they would.

  4. A. Jimenez

    Customer service never seems to disappoint! Always so helpful when I call.

  5. Kristopher Sage

    Decently priced peptides. Just got a discount code after my first purchase. Will definitely use that for the next one!

  6. Julia Holik

    I recommended you to all of my coworkers

  7. Matthew Garcia

    Awsome service, great pure products!!!!!!

  8. Daniel Manibog

    My experince with Biotech has been nothing but great. Never had an issue they weren’t able to handle.

  9. Eric Cho

    I only order products from here now, never disappointed by the quality and always enjoy speaking with customer service was very surprised by the level of customer service. This company sets a great example for how things should be run. Despite making an error on an order I placed, a customer service rep was kind enough to patiently assist in fixing the mistake.

  10. Larry Willingham

    Impressed with the quality of peptides and the quality of customer service. Excellent.

  11. Eric Wilson

    I made a mistake when inputting my information. Quick email to customer serice and they were able to fix the shipping address. I am glad too because I had made the order in the morning and I noticed it right before they shipped it out.

  12. Beatriz Davis

    The time between ordering products and them shipping them out is surprisingly quick. That is a major plus when working with peptides though.

  13. Art Decker

    Real happy with the results of my project with using biotech peptides. Can’t wait to try them out again with my upcoming projects.

  14. Aurora Clark

    Everything arrived neatly and without any breaks or cracks.

  15. Pat Conlan

    I switched to biotech Peptides about a year ago. It has completely changed the results of my research. I have noticed better results and Biotechs products prices are better than a lot of other sites.

  16. Alex McCane

    Been searching for the peptide for the past few days, it seems to be out of stock other sites but not here! Also amazed at how fast processing and shipment is with you all! I’ll be back for sure.

  17. Hayden Meadows

    You guys offer better prices and faster delivery than the other site I was using, so I switched.

  18. Adrian Franklin

    Since I’ve been buying peptides here for some time now, I can confidently claim that this is the greatest peptide source out there!

  19. Marco vito

    Ten out of ten would recommend

  20. Ariel Rosso

    Lovely staff and great quality

  21. Jonny Quezada

    Ordering process is quick and easy, just how I like it.

  22. Jake Haddock

    I never had any issues ordering from them

  23. Stanly Kim

    Had an issue with my peptides. It seems like my package got lost in the delivery shuffle and no one knows where it is. I e-mailed them as soon as I could and I had the pleasure of speaking and working with Taylor. They were fantastic and had the best customer service I’ve experienced in the peptide world. They saw what was going on as they couldn’t track it either and we just ended up canceling the order and placing a new one but rushed. I got my peptides in a little over a day. Still have no idea where the last package is.

  24. Eli Wendal

    I have gotten amazing results in my research. I recommend this if you are conducting studies with memory or cells. Did the job and gave me results that surpassed my expectations.

  25. Alex Peterson

    Pineal gland research is in full bloom. Very qualitative and high purity product. I will definitely order more

  26. Maz Flandez

    Estoy muy contento de que hacen envíos en mi país y hasta ahora no he tenido ningún problema con el envío.

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