No products in the cart
Pinealon peptides are Synthesized and Lyophilized in the USA.
Discount per Quantity
|Quantity||5 - 9||10 +|
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
What is the Pinealon Peptide?
Pinealon is a short peptide comprising only three amino acids. It is one of the few synthetic peptides considered to be a peptide bioregulator as it appears to interact directly with DNA to alter gene expression levels. It may cause behavior modification and protect various cell types, including neurons against hypoxia. Pinealon has been studied for its potential to affects the pineal gland to address issues with medication metabolism, circadian rhythm disorders, memory, learning, and more. Pinealon, unlike most other peptides, does not appear to bind to the cell surface or cytoplasmic receptors. Testing in cell cultures (HeLa cells) has suggested that the peptide penetrates the cell membrane directly, and the nuclear membrane interacts with DNA. The researchers conclude that “The site-specific interactions of peptides with DNA can control epigenetically the cell genetic functions, and they seem to play an important role in regulation of gene activity even at the earliest stages of life origin and in evolution.” Thus it may act as a regulator of gene expression and mediates myriad cellular effects.
AKA: Glutamylaspartylarginine, T-33 peptide
Molecular Formula: C15H26N6O8
Molecular Weight: 418.407 g/mol
Pinealon and Aging
Pinealon may have anti-aging effects on the central nervous system. It appears to be anabolic in the brain and may reduce the rate of aging when examined by biological age indicators. Pinealon appears to influence other tissues as well, such as muscles, by seemingly altering Irisin expression. Irisin protects muscle cells during exercise, enhances fat burning, and triggers telomere elongation. The peptide thus has the potential to protect the telomere and help overcome the effects of aging and oxidative stress. Interestingly, Irisin active outside muscles, leading scientists to theorize about Pinealon’s potential to regulate aging all over our body.
Pinealon and Neuron Protection
Research studies observe that Pinealon may protect neurons against oxidative stress in rats, enhancing cognitive function and motor coordination. According to the researchers, these “experiments allowed confirming the neuroprotective properties of pinealon, which is in agreement with the previous data obtained by us in vitro.” The study noted a significant reduction in both reactive oxygen species accumulation and necrotic cells in animal brains.
The peptide may have the potential to protect proliferation pathways to modify the cell cycle as part of its protection against cell death. Under oxidative stress, this effect controls the damaging effects of reactive oxygen species. It also increases the resistance of neurons to hypoxic stress through activation of innate anti-oxidative enzyme systems and reducing the excitotoxic effects of N-methyl-D-aspartate (NMDA). N-methyl-D-aspartate (NMDA) is an amino acid derivative that can be neurotoxic. Irisin levels in the central nervous system induce genes in the hippocampus that are important to memory, learning, and overall neuron health. Exercise directly improves levels of Irisin in the brain, thus associating physical activity and cognition.
Pinealon and Depression
The peptide may promote the expression of 5-tryptophan hydroxylase via epigenetic changes in brain cortex cells. 5-tryptophan hydroxylase is crucial for the production and secretion of serotonin. This peptide shows the potential for neuroprotective and geroprotective features and is the most common target of anti-depressive medications called selective-serotonin reuptake inhibitors (SSRIs). Pinealon may therefore provide a healthier alternative to boost serotonin compared to SSRIs.
Pinealon and Caspase-3, Cell Death
Researchers suggest that the peptide may alter cytokine signaling, which causes an increase in levels of the caspase-3 enzyme. Caspase-3 is directly initiating apoptosis through genetic instruction. By regulating caspase-3, Pinealon may block at least one pathway to cell death and thereby control the effects of oxygen deprivation during a stroke. The peptide may also reduce caspase-3 levels following myocardial infarction. The short peptide may have applications in treating heart attacks and controlling the long-term remodeling that causes dysfunction following myocardial infarction. Pinealon also appears to promote cell proliferation in young and old animals by blocking apoptosis in skin cells. This increases the regenerative process and offsets age-related pathology in the skin. Pinealon may eventually form part of a multi-faceted approach to wound healing and could apply everything from sun protection to serious burn treatment.
Pinealon and Sleep Regulation
It does not come as a surprise that Pinealon may affect both the sleep-wake cycle and sleep behavior. Research indicates that Pinealon may help control the dysfunction caused by shift work and other activities (e.g., long-distance travel) that interfere with normal sleep patterns. The peptide appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, improving sleep, depression, mood, blood pressure, etc. The ability to regulate sleep is associated strongly with rates of aging. Disturbed sleep is extremely hazardous to the body and affects cognition, cardiac health, wound healing, mood, and more. Pinealon may help reduce the impact of sleep disturbance and thereby offset its effects on aging. This could be beneficial to those forced into disorder sleep due to their jobs and individuals suffering from an organic disease that impacts sleep-wake cycles. Experimental studies report that Pinealon appears to exhibit minimal side effects and low oral and excellent subcutaneous bioavailability in mice. Per kg dosage in mice is not equivalent to humans.
- Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210-9. doi: 10.1134/S0006297911110022. PMID: 22117547.
- Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. Adv Gerontol. 2015;28(1):62-7. Russian. PMID: 26390612.
- Khavinson VKh, Kuznik BI, Tarnovskaya SI, Lin’kova NS. Short Peptides and Telomere Length Regulator Hormone Irisin. Bull Exp Biol Med. 2016 Jan;160(3):347-9. doi: 10.1007/s10517-016-3167-y. Epub 2016 Jan 8. PMID: 26742748.
- Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85. Epub 2012 Apr 6. PMID: 22567179; PMCID: PMC3342713.
- Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41. doi: 10.1089/rej.2011.1172. Epub 2011 Oct 6. PMID: 21978084.
- Khavinson VKh, Lin’kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO. Short peptides stimulate serotonin expression in cells of brain cortex. Bull Exp Biol Med. 2014 May;157(1):77-80. doi: 10.1007/s10517-014-2496-y. Epub 2014 Jun 10. PMID: 24909721.
- Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, Dem’ianenko SV. [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]. Adv Gerontol. 2014;27(1):94-7. Russian. PMID: 25051764.
- Bashkireva AS, Artamonova VG. [The peptide correction of neurotic disorders among professional truck-drivers]. Adv Gerontol. 2012;25(4):718-28. Russian. PMID: 23734521.
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
Zayn Atkinson –
Outstanding!!! Love their peptides.
Khaled Hadid –
Pleased customer here. I made a mistake selecting a delivery option and they covered Saturday delivery free.
Jasper Hall –
First purchase with these guys. So far so good, decently priced and products arrived when they said they would.
A. Jimenez –
Customer service never seems to disappoint! Always so helpful when I call.
Kristopher Sage –
Decently priced peptides. Just got a discount code after my first purchase. Will definitely use that for the next one!
Julia Holik –
I recommended you to all of my coworkers
Matthew Garcia –
Awsome service, great pure products!!!!!!
Daniel Manibog –
My experince with Biotech has been nothing but great. Never had an issue they weren’t able to handle.
Eric Cho –
I only order products from here now, never disappointed by the quality and always enjoy speaking with customer service was very surprised by the level of customer service. This company sets a great example for how things should be run. Despite making an error on an order I placed, a customer service rep was kind enough to patiently assist in fixing the mistake.
Larry Willingham –
Impressed with the quality of peptides and the quality of customer service. Excellent.
Eric Wilson –
I made a mistake when inputting my information. Quick email to customer serice and they were able to fix the shipping address. I am glad too because I had made the order in the morning and I noticed it right before they shipped it out.
Beatriz Davis –
The time between ordering products and them shipping them out is surprisingly quick. That is a major plus when working with peptides though.
Art Decker –
Real happy with the results of my project with using biotech peptides. Can’t wait to try them out again with my upcoming projects.
Aurora Clark –
Everything arrived neatly and without any breaks or cracks.
Pat Conlan –
I switched to biotech Peptides about a year ago. It has completely changed the results of my research. I have noticed better results and Biotechs products prices are better than a lot of other sites.
Alex McCane –
Been searching for the peptide for the past few days, it seems to be out of stock other sites but not here! Also amazed at how fast processing and shipment is with you all! I’ll be back for sure.
Hayden Meadows –
You guys offer better prices and faster delivery than the other site I was using, so I switched.
Adrian Franklin –
Since I’ve been buying peptides here for some time now, I can confidently claim that this is the greatest peptide source out there!
Marco vito –
Ten out of ten would recommend
Ariel Rosso –
Lovely staff and great quality
Jonny Quezada –
Ordering process is quick and easy, just how I like it.
Jake Haddock –
I never had any issues ordering from them
Stanly Kim –
Had an issue with my peptides. It seems like my package got lost in the delivery shuffle and no one knows where it is. I e-mailed them as soon as I could and I had the pleasure of speaking and working with Taylor. They were fantastic and had the best customer service I’ve experienced in the peptide world. They saw what was going on as they couldn’t track it either and we just ended up canceling the order and placing a new one but rushed. I got my peptides in a little over a day. Still have no idea where the last package is.
Eli Wendal –
I have gotten amazing results in my research. I recommend this if you are conducting studies with memory or cells. Did the job and gave me results that surpassed my expectations.
Alex Peterson –
Pineal gland research is in full bloom. Very qualitative and high purity product. I will definitely order more
Maz Flandez –
Estoy muy contento de que hacen envíos en mi país y hasta ahora no he tenido ningún problema con el envío.