Pinealon (20mg)

(26 customer reviews)

$68.00

Pinealon peptides are Synthesized and Lyophilized in the USA.

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Quantity 5 - 910 +
Discount 5%10%
Price $64.60$61.20
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FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
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SKU: Pinealon-20mg Category:

Description

Pinealon Peptide

Pinealon is a short peptide comprising only three amino acids. It is one of the few synthetic peptides considered to be a peptide bioregulator as it appears to interact directly with DNA to alter gene expression levels. It may potentially exhibit behavior modification and may protect various cell types, including neurons against hypoxia. Pinealon has been studied for its potential to impact the pineal gland to address issues with metabolism, circadian rhythm disorders, and certain cognitive functions. Pinealon, unlike most other peptides, does not appear to bind to the cell surface or cytoplasmic receptors. Testing in cell cultures (HeLa cells) has suggested that the peptide penetrates the cell membrane directly, and the nuclear membrane interacts with DNA.[1] The researchers conclude that “The site-specific interactions of peptides with DNA can control epigenetically the cell genetic functions, and they seem to play an important role in regulation of gene activity even at the earliest stages of life origin and in evolution.” Thus it may act as a regulator of gene expression and may mediate myriad cellular effects.

Specifications

Other Known Titles: Glutamylaspartylarginine, T-33 peptide

Sequence: Glu-Asp-Arg

Molecular Formula: C15H26N6O8

Molecular Weight: 418.407 g/mol

Pinealon Research

Pinealon and Cell Aging
Pinealon may have anti-aging impacts on cells, particularly noted within the central nervous system. It appears to be anabolic in the brain and may possibly reduce the rate of cell aging when examined against certain bioindicators.[2] Pinealon appears to influence other tissues as well, such as muscles, by seemingly altering Irisin expression. Irisin is considered by researchers to protect muscle cells during physical exertion, influence metabolic rate and trigger telomere elongation.[3] The peptide may exhibit potential to protect the telomere and help overcome the impacts of cell aging and oxidative stress.

Pinealon and Neuron Protection
Research studies observe that Pinealon may protect neurons against oxidative stress in rats, enhancing cognitive function and motor coordination.[4] According to the researchers, these “experiments allowed confirming the neuroprotective properties of pinealon, which is in agreement with the previous data obtained by us in vitro.” The study noted a significant reduction in both reactive oxygen species accumulation and necrotic cells in animal brains. The peptide may have the potential to protect proliferation pathways to modify the cell cycle as part of its protection against cell death.[5] Under oxidative stress, this effect is considered to control the damaging effects of reactive oxygen species. It appears also to increase the resistance of neurons to hypoxic stress through activation of innate anti-oxidative enzyme systems and reduce the excitotoxic effects of N-methyl-D-aspartate (NMDA). N-methyl-D-aspartate (NMDA) is an amino acid derivative that may be neurotoxic. Irisin levels in the central nervous system appear to induce genes in the hippocampus that are important to memory, learning, and overall neuron function.

Pinealon and Depression
The peptide may promote the expression of 5-tryptophan hydroxylase via epigenetic changes in brain cortex cells. 5-tryptophan hydroxylase is considered crucial for the production and secretion of serotonin.[6] This peptide may host potential for neuroprotective and geroprotective characteristics, and research has begun to examine its possible impact within the context of depression research.

Pinealon and Caspase-3, Cell Death
Researchers suggest that the peptide may alter cytokine signaling, which may induce an increase in levels of the caspase-3 enzyme. Caspase-3 is considered to directly initiate apoptosis through genetic instruction.[7] By regulating caspase-3, Pinealon may block at least one pathway to cell death and thereby may control the impact of oxygen deprivation, as suggested by experiments on research models of a stroke. The peptide may also reduce caspase-3 levels following myocardial infarction. The short peptide may have plausible outcomes within the context of research in heart attacks and controlling the long-term remodeling that causes dysfunction following myocardial infarction. Pinealon also appears to promote cell proliferation in young and old animals by blocking apoptosis in skin cells. This appears to increase the regenerative process and may offset age-related pathology in skin cells.

Pinealon and Sleep Regulation
Research indicates that Pinealon may help control certain sleep cycle dysfunctions. The peptide appears to reset the pineal gland to baseline in the setting of circadian rhythm disruption, which may have multifaceted downstream impacts.[8] Disturbed sleep is considered extremely hazardous to the organism over time. Pinealon may help reduce the impact of sleep disturbance and thereby offset its impact. Research is ongoing.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Fedoreyeva LI, Kireev II, Khavinson VKh, Vanyushin BF. Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA. Biochemistry (Mosc). 2011 Nov;76(11):1210-9. doi: 10.1134/S0006297911110022. PMID: 22117547.
  2. Meshchaninov VN, Tkachenko EL, Zharkov SV, Gavrilov IV, Katyreva IuE. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. Adv Gerontol. 2015;28(1):62-7. Russian. PMID: 26390612.
  3. Khavinson VKh, Kuznik BI, Tarnovskaya SI, Lin’kova NS. Short Peptides and Telomere Length Regulator Hormone Irisin. Bull Exp Biol Med. 2016 Jan;160(3):347-9. doi: 10.1007/s10517-016-3167-y. Epub 2016 Jan 8. PMID: 26742748.
  4. Arutjunyan A, Kozina L, Stvolinskiy S, Bulygina Y, Mashkina A, Khavinson V. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5(2):179-85. Epub 2012 Apr 6. PMID: 22567179; PMCID: PMC3342713.
  5. Khavinson V, Ribakova Y, Kulebiakin K, Vladychenskaya E, Kozina L, Arutjunyan A, Boldyrev A. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14(5):535-41. doi: 10.1089/rej.2011.1172. Epub 2011 Oct 6. PMID: 21978084.
  6. Khavinson VKh, Lin’kova NS, Tarnovskaya SI, Umnov RS, Elashkina EV, Durnova AO. Short peptides stimulate serotonin expression in cells of brain cortex. Bull Exp Biol Med. 2014 May;157(1):77-80. doi: 10.1007/s10517-014-2496-y. Epub 2014 Jun 10. PMID: 24909721.
  7. Mendzheritskiĭ AM, Karantysh GV, Ryzhak GA, Dem’ianenko SV. [Regulation of content of cytokines in blood serum and of caspase-3 activity in brains of old rats in model of sharp hypoxic hypoxia with Cortexin and Pinealon]. Adv Gerontol. 2014;27(1):94-7. Russian. PMID: 25051764.
  8. Bashkireva AS, Artamonova VG. [The peptide correction of neurotic disorders among professional truck-drivers]. Adv Gerontol. 2012;25(4):718-28. Russian. PMID: 23734521.
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This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

26 reviews for Pinealon (20mg)

  1. Zayn Atkinson

    Outstanding!!! Love their peptides.

  2. Khaled Hadid

    Pleased customer here. I made a mistake selecting a delivery option and they covered Saturday delivery free.

  3. Jasper Hall

    First purchase with these guys. So far so good, decently priced and products arrived when they said they would.

  4. A. Jimenez

    Customer service never seems to disappoint! Always so helpful when I call.

  5. Kristopher Sage

    Decently priced peptides. Just got a discount code after my first purchase. Will definitely use that for the next one!

  6. Julia Holik

    I recommended you to all of my coworkers

  7. Matthew Garcia

    Awsome service, great pure products!!!!!!

  8. Daniel Manibog

    My experince with Biotech has been nothing but great. Never had an issue they weren’t able to handle.

  9. Eric Cho

    I only order products from here now, never disappointed by the quality and always enjoy speaking with customer service was very surprised by the level of customer service. This company sets a great example for how things should be run. Despite making an error on an order I placed, a customer service rep was kind enough to patiently assist in fixing the mistake.

  10. Larry Willingham

    Impressed with the quality of peptides and the quality of customer service. Excellent.

  11. Eric Wilson

    I made a mistake when inputting my information. Quick email to customer serice and they were able to fix the shipping address. I am glad too because I had made the order in the morning and I noticed it right before they shipped it out.

  12. Beatriz Davis

    The time between ordering products and them shipping them out is surprisingly quick. That is a major plus when working with peptides though.

  13. Art Decker

    Real happy with the results of my project with using biotech peptides. Can’t wait to try them out again with my upcoming projects.

  14. Aurora Clark

    Everything arrived neatly and without any breaks or cracks.

  15. Pat Conlan

    I switched to biotech Peptides about a year ago. It has completely changed the results of my research. I have noticed better results and Biotechs products prices are better than a lot of other sites.

  16. Alex McCane

    Been searching for the peptide for the past few days, it seems to be out of stock other sites but not here! Also amazed at how fast processing and shipment is with you all! I’ll be back for sure.

  17. Hayden Meadows

    You guys offer better prices and faster delivery than the other site I was using, so I switched.

  18. Adrian Franklin

    Since I’ve been buying peptides here for some time now, I can confidently claim that this is the greatest peptide source out there!

  19. Marco vito

    Ten out of ten would recommend

  20. Ariel Rosso

    Lovely staff and great quality

  21. Jonny Quezada

    Ordering process is quick and easy, just how I like it.

  22. Jake Haddock

    I never had any issues ordering from them

  23. Stanly Kim

    Had an issue with my peptides. It seems like my package got lost in the delivery shuffle and no one knows where it is. I e-mailed them as soon as I could and I had the pleasure of speaking and working with Taylor. They were fantastic and had the best customer service I’ve experienced in the peptide world. They saw what was going on as they couldn’t track it either and we just ended up canceling the order and placing a new one but rushed. I got my peptides in a little over a day. Still have no idea where the last package is.

  24. Eli Wendal

    I have gotten amazing results in my research. I recommend this if you are conducting studies with memory or cells. Did the job and gave me results that surpassed my expectations.

  25. Alex Peterson

    Pineal gland research is in full bloom. Very qualitative and high purity product. I will definitely order more

  26. Maz Flandez

    Estoy muy contento de que hacen envíos en mi país y hasta ahora no he tenido ningún problema con el envío.

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