PT-141 (Bremelanotide) (10mg)

(39 customer reviews)

$38.00

PT-141 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$36.10$34.20
Orders over $300 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: PT-141-10mg Category:

Description

What is the PT-141 Peptide?

PT-141, also known as bremelanotide, has been investigated in phase IIb human clinical trials to treat female hypoactive sexual desire disorder (HSDD). It was derived from a synthetic Melanocortin known as Melanotan 2 (MT-2). PT-141 is a Melanocortin that  was developed to interact with Melanocortin-4 Receptor (MC-4R) and MC-1R. PT-141 has been studied for a variety of potential benefits, including implications in sexual dysfunction and cancer, and in aiding hemorrhages.

Specifications

AKA: Bremelanotide

Molecular Formula: C50H68N14O10

Molecular Weight: 1025.2 g/mol

Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)-OH

PubChem: CID 9941379

CAS Number: 189691-06-3

Reconstitution: Required

PT-141 Research

PT-141 Peptide (Bremelanotide) and Sexual Arousal
PT-141 appears to uniquely stimulate the MC-4R, which may trigger sexual arousal in the central nervous system and can affect sexual behavior.[1] The researchers report that “The erectogenic potential of PT-141, its tolerability profile and its ability to cause significant erections in patients who do not have an adequate response to a PDE5 inhibitor suggest that PT-141 may provide an alternative treatment for ED with a potentially broad patient base.” Studies in mice agonist binding to MC-4R reported sexual arousal and enhanced copulation in both males and females.[2] The mechanism of PT-141 is different from medications like Viagra; it has the potential to treat both male and female sexual arousal disorders that are not caused by reduced blood flow to the genitals. One-third of men who suffered from erectile dysfunction (ED) but did not respond to sildenafil (Viagra) appeared to experience satisfactory erection for sexual intercourse using PT-141 (administered via nasal spray). The strong dose-dependent response in the trial indicated the effectiveness of PT-141 in some cases.  Interestingly, it was removed from clinical trials for treating women with HSDD despite showing increased female sexual satisfaction and reducing female sexual distress scores without side effects.[3] Experts on female sexual dysfunction (FSD) consider a lack of established endpoints for trials of FSD and socio-cultural biases against women’s sexual health as the essential reasons for the  non-approval of PT-141.[4] Researchers suggest the PT-141 treatment if combined with other existing modalities may enhance both physiological and psychological efficacies. In 2017, partly due to the outcry against the cessation of earlier trials, Phase II Reconnect trials were initiated for PT-141 for FSD, and research reporting is ongoing.

PT-141 Peptide (Bremelanotide) and Infection
The MC-1R appears to mediate important anti-fungal and anti-inflammatory effects in a rat model of specific fungal infection.[5] This may be relevant to PT-141 peptides as current medications have limited mechanisms of action and show adverse effects in some patients. The alternative therapy might control morbidity and mortality, especially in immunocompromised patients.

PT-141 Peptide (Bremelanotide) and Hemorrhage
In 2009, modified PT-141 was investigated for use in hemorrhagic shock. The peptide appears to control ischemia and protect tissues against inadequate blood supply hypovolemic (hemorrhagic) shock through interaction with both MC-1R and MC-4R. It was observed in phase IIb trials that the administration of the peptide exhibited no side effects. The modified version is referred to as PL-6983.

PT-141 Peptide (Bremelanotide) and Cancer
The MC-1R receptor may be an important stimulus of DNA repair pathways, and is of relevance in cancer research and prevention.[6] The scientists reported that “MC1R signalling activates antioxidant, DNA repair and survival pathways.” People with variants of MC-1R appear to be more prone to both basal cell and squamous cell carcinoma.[7] Altered PT-141 may be used to bind to these variants and prevent or treat these cancers.

Direction of Future Studies for PT-141 Peptide

Right now, PT-141 is well known for its potential in sexual dysfunction research. There is potential to expand its research in other diseases. For instance, a mutant or deleted MC-4R may trigger some instances of obesity and influence about 6% of early-onset obesity cases. PT-141 may help to study this specific reason for obesity and illustrate a pathway for intervention. MC-1R has also been associated with pain, inflammation, kidney pathology, and the spread of infection; the peptide may help investigate diverse research domains. Experimental research in PT-141 reports the peptides appears to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage (per kg) in mice does not match humans.

References

  1. Rosen RC, Diamond LE, Earle DC, Shadiack AM, Molinoff PB. Evaluation of the safety, pharmacokinetics and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. Int J Impot Res. 2004 Apr;16(2):135-42. doi: 10.1038/sj.ijir.3901200. PMID: 14999221.
  2. Rössler AS, Pfaus JG, Kia HK, Bernabé J, Alexandre L, Giuliano F. The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat. Pharmacol Biochem Behav. 2006 Nov;85(3):514-21. doi: 10.1016/j.pbb.2006.09.023. Epub 2006 Nov 20. PMID: 17113634.
  3. Clayton AH, Althof SE, Kingsberg S, DeRogatis LR, Kroll R, Goldstein I, Kaminetsky J, Spana C, Lucas J, Jordan R, Portman DJ. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Womens Health (Lond). 2016 Jun;12(3):325-37. doi: 10.2217/whe-2016-0018. Epub 2016 May 16. PMID: 27181790; PMCID: PMC5384512.
  4. Miller MK, Smith JR, Norman JJ, Clayton AH. Expert opinion on existing and developing drugs to treat female sexual dysfunction. Expert Opin Emerg Drugs. 2018 Sep;23(3):223-230. doi: 10.1080/14728214.2018.1527901. Epub 2018 Oct 11. PMID: 30251897.
  5. Ji HX, Zou YL, Duan JJ, Jia ZR, Li XJ, Wang Z, Li L, Li YW, Liu GY, Tong MQ, Li XY, Zhang GH, Dai XR, He L, Li ZY, Cao C, Yang Y. The synthetic melanocortin (CKPV)2 exerts anti-fungal and anti-inflammatory effects against Candida albicans vaginitis via inducing macrophage M2 polarization. PLoS One. 2013;8(2):e56004. doi: 10.1371/journal.pone.0056004. Epub 2013 Feb 14. PMID: 23457491; PMCID: PMC3573073.
  6. Maresca V, Flori E, Picardo M. Skin phototype: a new perspective. Pigment Cell Melanoma Res. 2015 Jul;28(4):378-89. doi: 10.1111/pcmr.12365. Epub 2015 Apr 11. PMID: 25786343.
  7. Feller L, Khammissa RAG, Kramer B, Altini M, Lemmer J. Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face. Head Face Med. 2016 Feb 5;12:11. doi: 10.1186/s13005-016-0106-0. PMID: 26850723; PMCID: PMC4744388.
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

39 reviews for PT-141 (Bremelanotide) (10mg)

  1. Liam Lewis

    Amazing product. I wll be back for more

  2. Liam Lewis

    I found this product to show visible results

  3. Kamari Clark

    Ive ordered twice so far and my bacteriostatic water was missing. Well, it was my fault for not having met the minimum purchase requirement but I was sent one free of charge and they even covered shipping. What more could I ask for. Thank you team at Bio

  4. Felix Stewart

    Great and fast customer service.

  5. Samuel B.

    I highly advise buying peptides from this particular company. They are very transparent

  6. London Wright

    I find this company and its products to be excellent.

  7. Jose Gonzalez

    very good

  8. Leigh Mueller

    Having a reliable peptide source in the United States is a huge blessing for me.

  9. Hayden Foster

    Not sure what happened but we got a few vials that were broken. My company has ordered products from here before with no issues so could be from shipping. They apologized and sent out new ones with overnight shipping. Also threw in a discount code for our next time.

  10. Jean-Carlo Lopez

    Servicio increíble!

  11. James Avenoso

    Please introduce a punch card or something or coupon codes. I’ve brought you a lot of clients and I would love to maybe get a 5% discount for every person using my code

  12. Christian Mendoza

    They have been out of stock of the paticular peptide I need for weeks now. So decided to call and see what was up. They we’re about to get some out shortly and just took my order and payment over the phone. Even threw in a discount because the wait was so long.

  13. Joe McConnell

    Taylor is magnificinet and truly knows their stuff. Anytime I have contacted them to correct something or if i have any questions they were always on top of it and had an answer.

  14. Geroge Salvini

    Had an issue where all my peptide vials came in either broken or completely degraded. Right away reached out to customer service as something went wrong from once it left the facility to ending up at my lab. They were kindhearted enough to put in a rush order for me free of charge and send in a discount code to use for the next few transactions. Now any peptide company could resend orders, but it was the “no problem” attitude and great CS that sets them apart for me.

  15. Matty Donovan

    Great supply of peptides. Like that they take different payment methods!

  16. Gabriel Miller

    Peptides have always come in great condition. I like that they always have the Pt-141 on stock anytime I need it!

  17. Ali Murphy

    I belive their products are one of the best in the market. Can count on them for good quality.

  18. Richard S.

    Great new company, excited to see how they grow.

  19. Declan Walker

    Best prices I have found for this particular peptide. Noticed a lot of your pricing is less that other places as well.

  20. dennis long

    Good source to get Peptides from.

  21. C. Carter

    Had a diffciult time with customs! As I live in Canada there was a whole ordeal with getting the peptides in time. What should have been a two day shipment turned into almost 2 weeks. At that point I knew there’s no way the peptides would be in good condition but I had hope. Low and behold my assumption was right and all the peptides went straight to waste. I contacted Biotech to let them know what was going on. Thankfully they were able to rush me a new order and this time no issues with customs.

  22. Jeremy Schablewski

    Service is unbeatble. The service reps always have an answer to my questions and know a lot about the products and the company itself.

  23. Chad Dela Cruz

    Could not believe how great the qulaity is for the price.

  24. Arthur McAllister

    Amazing company and products. Will buy again

  25. Marco Gonzalez

    great quality, Have ordered with them a few times, have not had a bad experince yet.

  26. Vinny Haley

    Peptides arrived on time. Used it for the first time and my research reacted well to it.

  27. Gavin Markowitz

    Nice selection of peptides, did not see a specific few that I was looking for however.

  28. Danny Williams

    I like how their customer service is always well informed and up to date on all the peptide information. Very helpful staff

  29. Dan Benaroch

    Ordering in bulk from them is so easy, compared to other places I have shopped before

  30. Gabriel Browndorf

    Products are pure. Top 5 peptide companies in my book.

  31. Henry Chan

    Found them off google, happy I did.

  32. Wendy Martinez

    I wish I could give this company more than 5 stars, great in every way

  33. Javier Laurent

    I find it pretty difficult to find this product online on other suppliers’ websites, but Biotech always has everything I need

  34. Edmond Amataj

    Good quality stuff for a great price, no complaints

  35. Danny Hendricks

    Research results are no different with any other peptide source, however the service and fast shipping is what makes biotech my supplier of choice.

  36. Jess Jiang

    Great stuff!

  37. Praneel Gulabrao

    Fantastic service on their end

  38. Mitchell Mauldin

    Been buying their products for months now and can say It’s the best place to get peptides from

  39. Geri Coleman

    I always recommend them to those doing peptide research. Clean and pure peptides as well as great customer service and prices.

Add a review