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Semaglutide (GLP-1) (3mg & 5mg)

(31 customer reviews)

$113.00$179.00

Semaglutide (GLP-1) peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$107.35$170.05$101.70$161.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Semaglutide-GLP-1 Category:

Description

What is the Semaglutide (GLP-1) peptide?

Semaglutide (GLP-1) and glucagon-like peptide 1 are short, natural peptides. The naturally occurring hormone is only 3031 amino acids in length, with a primary physiological function to lower blood sugar levels by naturally increasing insulin secretion. It also appears to protect beta-cell insulin stores by promoting transcription of insulin genes, and is associated with neurotrophic effects in the central nervous system and the brain. Studies in the GI system have observed that Semaglutide may significantly reduce appetite by slowing gastric emptying and bowel motility. Preliminary studies have also suggested potential effects of Semaglutide on the heart, fat, muscles, bones, liver, lungs, lungs, and kidneys.

Specifications

Synonyms: GLP-1, proglucagon (72-108), glucagon-like peptide-1

Molecular Formula: C187H291N45O59

Molecular Weight: 4113.64 g/mol

Sequence: HXEGTFTSDV SSYLEGQAAK EFIAWLVRGR G

PubChem: CID 56843331

CAS Number: 910463-68-2

Reconstitution: Required

Semaglutide Research

Semaglutide and the Incretin Effect
According to Holst, the most widespread association with Semaglutide is the “incretin effect.”[1] Incretins are a group of metabolic hormones released from the gastrointestinal tract that lower blood sugar (sugar) levels. Semaglutide appears to be one of the two most common and essential hormones that stimulate incretin action in the rodent model (the other is GIP). GIP circulates at about 10 times the concentration of Semaglutide, but there is evidence that GLP-1 may be more potent than GIP, especially when blood glucose levels are relatively high.[2] The researcher also notes that “Decreased secretion of GLP-1 may contribute to the development of obesity, and exaggerated secretion may be responsible for postprandial reactive hypoglycemia.” Semaglutide receptors have been identified on the surface of pancreatic beta cells, suggesting that Semaglutide may directly stimulate insulin exocytosis from the pancreas. In combination with the sulfonylurea substance, Semaglutide has been suggested to increase insulin secretion. Various potential nutritional effects include a possible increase in protein synthesis, decreased proteolysis, and increase in amino acid uptake by skeletal muscle.

Semaglutide and Beta Cell Protection
Studies in animal models suggest that Semaglutide may stimulate the growth and proliferation of pancreatic beta cells and the differentiation of new forms of beta cells, precursors of pancreatic duct epithelium. Studies further theorize that Semaglutide may inhibit beta-cell apoptosis. These effects have the potential to upset the average balance between beta-cell growth and death. In terms of development, these research results posit the peptide’s potential to treat diabetes and protect the pancreas from attacks that damage beta cells. One particularly compelling study has indicated that Semaglutide appears to inhibit beta-cell death caused by elevated levels of inflammatory cytokines. In fact, in type 1 mouse models with diabetes, it was observed that Semaglutide appeared to protects islet cells from destruction, and therefore it may be a valuable tool in practice to prevent the onset of type 1 diabetes.[3] The scientists suggested that “It is possible that such combined therapy could become a new strategy to defeat T1DM in humans.”

Semaglutide and Appetite
A study of mouse models suggests that administration of Semaglutide in the brain of mice may reduce the driving device and may inhibit food intake.[4] Semaglutide seems to induce satiation, reducing hunger instincts. Recent clinical trials are shown in the mouse where two-day management of the GLP-1 receptor agonist may cause gradual weight loss. This weight loss may lead to a significant improvement in cardiovascular risk factors and a decrease in hemoglobin A1C mirror for a long time.

Potential Cardiovascular Benefits of Semaglutide
Currently, Semaglutide receptors are distributed throughout the heart, and appear to improve cardiac function in certain situations by increasing heart rate and lowering left ventricular end-diastolic pressure.[5] A rise in end-diastolic pressure is often associated with left ventricular hypertrophy, cardiac remodeling, and ultimate heart failure. Recent studies suggest that Semaglutide may reduce the overall damage caused by a heart attack. The peptide appears to improve glucose uptake into the heart muscle; this helps the struggling ischemic myocardium maintain function and obtain the nutrients needed to avoid programmed cell death. Increased glucose uptake in these cells appears to be independent of insulin. High doses of Semaglutide in dogs have exhibited apparent improved and reduced LV performance and systemic vascular resistance. The latter effect may help lower blood pressure and relieve stress. This process, in turn, may help reduce the long-term consequences such as LV remodeling, vascular thickening, and heart failure. According to Dr. Horst, administration of GLP-1 after heart injury consistently appeared to improve myocardial performance in both experimental animal models and patients.

Semaglutide and the Brain
There is potential evidence that Semaglutide may help to enhance learning and protect neurons from neurodegenerative diseases such as Alzheimer’s. One study has posited that Semaglutide may enhance associative and spatial learning in mice and improve learning disabilities in mice with specific gene defects. In rats that overexpress Semaglutide receptors in particular brain areas, both learning and memory appear to be significantly better than normal controls.[6] Further research studies of mice indicated the peptide’s potential to protect from immunotoxic neurons. Interestingly, Semaglutide and its analog exendin-4 have been reported in mouse models to apparently reduce amyloid-beta levels in the brain. The beta-amyloid precursor protein found in neurons is the primary component of the plaques observed in Alzheimer’s disease.[7]
It remains to be seen if preventing amyloid-beta accumulation can protect against the effects of Alzheimer’s disease. Still, this research is, at the very least, a tantalizing clue as to how scientists may intervene in the progression of mild cognitive impairment to whole Alzheimer’s disease. Semaglutide (GLP-1) has so far been reported to exhibit minimal to moderate side effects and low oral and excellent subcutaneous bioavailability in mice, according to laboratory studies.[8]

References

  1. Holst JJ. From the Incretin Concept and the Discovery of GLP-1 to Today’s Diabetes Therapy. Front Endocrinol (Lausanne). 2019 Apr 26;10:260. doi: 10.3389/fendo.2019.00260. PMID: 31080438; PMCID: PMC6497767.
  2. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007 Oct;87(4):1409-39. doi: 10.1152/physrev.00034.2006. PMID: 17928588.
  3. Yang Z, Chen M, Carter JD, Nunemaker CS, Garmey JC, Kimble SD, Nadler JL. Combined treatment with lisofylline and exendin-4 reverses autoimmune diabetes. Biochem Biophys Res Commun. 2006 Jun 9;344(3):1017-22. doi: 10.1016/j.bbrc.2006.03.177. Epub 2006 Apr 5. PMID: 16643856.
  4. Tang-Christensen M, Larsen PJ, Thulesen J, Rømer J, Vrang N. The proglucagon-derived peptide, glucagon-like peptide-2, is a neurotransmitter involved in the regulation of food intake. Nat Med. 2000 Jul;6(7):802-7. doi: 10.1038/77535. PMID: 10888930.
  5. Gros R, You X, Baggio LL, Kabir MG, Sadi AM, Mungrue IN, Parker TG, Huang Q, Drucker DJ, Husain M. Cardiac function in mice lacking the glucagon-like peptide-1 receptor. Endocrinology. 2003 Jun;144(6):2242-52. doi: 10.1210/en.2003-0007. PMID: 12746281.
  6. During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN. Glucagon-like peptide-1 receptor is involved in learning and neuroprotection. Nat Med. 2003 Sep;9(9):1173-9. doi: 10.1038/nm919. Epub 2003 Aug 17. PMID: 12925848.
  7. Perry T, Haughey NJ, Mattson MP, Egan JM, Greig NH. Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J Pharmacol Exp Ther. 2002 Sep;302(3):881-8. doi: 10.1124/jpet.102.037481. PMID: 12183643.
  8. Perry TA, Greig NH. A new Alzheimer’s disease interventive strategy: GLP-1. Curr Drug Targets. 2004 Aug;5(6):565-71. doi: 10.2174/1389450043345245. PMID: 15270203.
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

Size

5mg, 3mg

31 reviews for Semaglutide (GLP-1) (3mg & 5mg)

  1. Gary Shultze

    I value a great company that values customers and having great products such as Biotech Peptides!

  2. Aspen Sanders

    We are happy with biotech and their services. The peptides are always promptly delivered and in perfect condition.

  3. Emon Kai

    The website is simple to use, orders can be tracked, and the things came on time.

  4. Heather B. Moore

    Exceptionally high-quality goods. Definitely a terrific discovery. Going to stick with these folks. Like the fact that their website is full of informative blogs and articles as well. Nice places to refresh yourself on peptides and each of their qualities and uses!

  5. Micthell Maynard

    The peptides are okay, Customer service is okay as well.

  6. David santiago

    Nice find! Everything is priced well, no excessive wait times for restocks either.

  7. Kelly hall

    Great peptides, My lab has been recommending them for the past year and I truly appreciate the great find.

  8. Marvin sulivan

    They are fast with their shipments. Placed in order in the morning and got an email saying that it was shipped out a few hours later!

  9. Xavier Cedeno

    No mix up with any of my orders, everything came on time.

  10. Erick Paez

    Good peptides.

  11. Arthas Frostmourne

    all around exceptional company.

  12. Aaron Jay

    You get what you pay for with them! Good quality without breaking the bank.

  13. James Gilmore

    High quality products!

  14. Billy Hosking

    Company is great, I like the customer service. Peptides are one of the best quality out there right now.

  15. Allen Wu

    Clean and nice packaging

  16. Gianni Thomas

    Nice range of peptides, I noticed they don’t have as much topical options though.

  17. Aron Cage

    My go to Peptide spot, always have what I need and prices are the best out there for the quality

  18. Ross Knapp

    Packaged, shipped, and delivered all within 48 hours. Love it

  19. John Malchar

    My peptides unfortunatly showed up a few days after the initial delivery date. Peptides came in great but I let them know I was not happy with the situation. They sent a discount code for my next purchase but I hope this doesn’t happen a second time.

  20. Jesse Campos

    Came here after reading about it on the blog site! Had to get for my project!

  21. Neal Chandani

    Prices haven’t been effected here as much, still priced at an affordable rate

  22. Dennis Marton

    10/10

  23. Dylan Gates

    Great stuff. I think this is the best priced semaglutide I have come upon in a while. Prices fluctuate but for the type of product it’s worth it. I just think packaging could be better.

  24. Aaronl Davis

    5 stars

  25. Chris Daniels

    Works well with my research

  26. Mickey Coleman

    Just got my first package of peptides today. Surprised by how quick I received them actually. Everything was correct, nothing missing or broken which is always great. I did receive a tracking number as well for the order. I am happy that they put a discount voucher in my box as well!

  27. Vinny Ivann

    Nicely priced! Doesn’t break the bank.

  28. Hunter Blumrick

    They truly have some great peptides and a phenomenal variety as well. Really hard to find a seller with this many options for topical peptides.

  29. Warren Townson

    Could not rave more about them. The products speak for themselves. I do want to note how great their policies are regarding their products and the rights us consumers have here.

  30. Ari Mathos

    Soy cliente desde hace mucho tiempo y me encanta esta empresa.

  31. Paul Garcxia

    Fast Service, quality product! Definitely Recommend!

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