Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.9 g/mol
PubChem: CID 16129620
CAS Number: 86168-78-7
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85 g/mol
PubChem: CID 20754357
CAS Number: 170851-70-4
What is Sermorelin & Ipamorelin Peptides Blend?
Combinatorial use of Sermorelin & Ipamorelin peptides blend is possibly the best method to induce the maximal release of growth hormone. Sermorelin happens to be a newly developed growth hormone-releasing hormone (GHRH) analog. It not only maintains the benefits of natural GHRH but also helps to avoid a few undesirable effects. One of how sermorelin is a better choice than GHRH is its mechanism of action. It acts via a negative feedback mechanism. This action means that its products will be automatically ceased in the case of its excess. This process reduces the adverse effects of GH excess in the body.
Similarly, Ipamorelin is the most specific and targeted analog of ghrelin/growth hormone secretagogue in recent studies. It is a selective peptide agonist of the ghrelin hormone. It mainly works to increase the circulating levels of GH in both animals and humans. Upon combination, these peptides act synergistically to induce maximal production of the growth hormone. The synergy thus amplifies the benefits of GH on brain health, muscle growth, cardiac balance, and metabolism.
Sermorelin has been shown to have multiple beneficial effects on different body systems. Research reveals that sermorelin can effectively reduce seizure activity in the body by activating GABA receptors. Its negative feedback mechanism of action also makes it a more preferred candidate over GH in growth disorders. The targeted influence of sermorelin brings about improved growth hormone effects on the heart. A study conducted in pigs reveals that the peptide decreases cell death of cardiomyocytes, promotes healing post-cardiac injury, Angiogenesis, and subsides inflammation.
It has been shown to reduce the scar size by increasing extracellular matrix production. Newer studies have also shown an improved diastolic function under the effect of sermorelin. The recent finding highlights the presence of a variant of the ghrelin receptor in cardiac tissues. The variant form has been observed to regulate cardiac output.
Therefore, using ghrelin and ghrelin analogs reduces the risk of cardiac arrhythmias and promotes healing after cardiac injury. Not only this, but sermorelin use has now been advocated to treat valvular heart diseases and cardiac failure.
Sermorelin & Ipamorelin peptide blends have specific GH-related advantages. These effects are more pronounced in comparison with other GH-releasing peptides. When taken in combination, both of these peptides have shown numerous benefits. These include increased bone density, improved mental wellness and clarity, and quicker recovery from workout injuries. Animal studies have shown that in addition to cardiac wellbeing, sermorelin positively influences the central nervous system to improve sleep quality.
This effect of sermorelin on the sleep cycle is mediated via its production of orexin. Orexin is a potent neurotransmitter with a proven effect on the sleep cycle. Adding to the fact that most of the healing and growth occurs during sleep, sermorelin plays a two-way role in sleep disorders associated with defective growth.
Ipamorelin is another revolutionary discovery. It is not a hormone in itself. Instead, it works by molecular mimicry of ghrelin, triggering the pituitary gland mainly to produce its natural growth hormones. This mechanism of action of ipamorelin eliminates the multitude of side effects that comes with the use of synthetic growth hormones. Ipamorelin has been shown to influence the growth hormone effects selectively.
It mainly increases bone density and bone mass. Ipamorelin has been commonly used in HIV patients to strengthen their immune systems. It also improves the health of skin, hair, and nails. Ipamorelin has been associated with improved bone health, insulin balance in diabetes, and bowel movement (especially post-surgery).