SNAP-8 (Topical) (200mg)

SNAP-8 Peptide

A synaptosome-associated protein called SNAP-25 is responsible for muscle contraction that leads to the formation of wrinkles along the skin surface.^[1] The acetyl hexapeptide-3 appears to mimic its peptide fragment and has an reported inhibitory effect on the action of SNAP-25. This protein has also been examined extensively within the context of cell aging, particularly skin cell research studies. The addition of two other amino acids in this hexapeptide forms acetyl octapeptide, which is another frequently cited research compound.^[2] SNAP-8 competes with SNAP-25 for a position in the SNARE complex. After the attachment of SNAP-8, the SNARE complex appears to be destabilized, potentially inhibiting the neurotransmitters, so that they are restricted in their release from the vesicles. This is considered to lead to an attenuation of muscle contraction, preventing repetitive creasing along the skin surface. The synthesizing and manufacturing of SNAP-8 comprises a final freeze-drying step called lyophilization. Generally, the crystalline powder obtained due to freeze-drying is in the form of a polymorphous compound. It may be present in aggregates and show variation in the crystal size. However, this does not appear to lead to any chemical discrepancy in its composition. Extensive experimental studies have supported the homogeneity of this product. The usual shelf life of SNAP-8 is posited to be least 12 months, provided the compound is stored in a clean, cool, and dry place. If the compound is intended to be stored longer than a year, the temperature should be maintained at 4 degrees Celsius. This may extend the shelf life to approximately 18 months. Refrigeration of the SNAP-8 may potentially lead to its precipitation; however, this doesn’t appear to change the integrity of the compound.

Specifications

OTHER KNOWN TITLES: Acetyl Glutamyl Heptapeptide-3

MOLECULAR FORMULA: C₄₁H₇₀N₁₆O₁₆S

MOLECULAR WEIGHT: 1075.16 g/mol

SEQUENCE: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

SNAP-8 Research

SNAP-8 and Wrinkle Depth
Research studies have suggested SNAP-8 may exhibit reduction capacity in the depth of wrinkles along the skin surface due to a possible resistance to contraction of the muscles. Some studies have suggested peptide exposure may lead to a decrease in wrinkle depth by as much as 30% with studies reporting SNAP-8 exposure for only one month.^[3]  According to the researchers, “it is also worth to be remarked that in vitro assay highlighted an independent mechanism but synergistic effect between SNAP-8 and Leuphasyl, each one tested independently and resulting with 38% and 7% inhibition, respectively. In the trial, including both of them in equal concentrations (0.75 mM), a total inhibition value of 47% was observed.”

SNAP-8 and Botulinum Toxin
Botulinum toxin has been extensively studied and is commonly considered to restrict muscle contraction and thereby inhibit wrinkles. SNAP-8 appears to target the same wrinkle-forming mechanism via a differing mechanism of action. Botulinum toxin is considered to attack and break SNAP-25. This may lead to muscle paralysis, inhibiting muscle contraction.^[4] SNAP-8 appears to capture the SNAP-25 protein, thereby destabilizing the SNARE complex. This is considered to lead to the inefficient release of neurotransmitters responsible for muscle contraction.^[5] According to the researchers the peptide may potentially act by “preventing neuromuscular signal propagation, thereby eliminating wrinkles caused by over-stimulated neurons.”

SNAP-8 and Hydration, Anti-Oxidation
Like other comparable peptides, SNAP-8 appears to possess water-binding capacity.^[6] Therefore, it may help the extracellular matrix of skin retain moisture. Alongside its possible hydration retaining characteristics, the peptide has been observed to exert protective impact against reactive oxygen species. Reactive oxygen species or free radicals are considered to have a major degenerative effect on skin cells.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References