SNAP-8 (Topical) (200mg)

(11 customer reviews)


SNAP-8 peptides are Synthesized and Lyophilized in the USA.

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Quantity 5 - 910 +
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Price $163.40$154.80
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SKU: SNAP-8-200mg Category:


SNAP-8 Peptide

A synaptosome-associated protein called SNAP-25 is responsible for muscle contraction that leads to the formation of wrinkles along the skin surface.[1] The acetyl hexapeptide-3 appears to mimic its peptide fragment and has an reported inhibitory effect on the action of SNAP-25. This protein has also been examined extensively within the context of cell aging, particularly skin cell research studies. The addition of two other amino acids in this hexapeptide forms acetyl octapeptide, which is another frequently cited research compound.[2] SNAP-8 competes with SNAP-25 for a position in the SNARE complex. After the attachment of SNAP-8, the SNARE complex appears to be destabilized, potentially inhibiting the neurotransmitters, so that they are restricted in their release from the vesicles. This is considered to lead to an attenuation of muscle contraction, preventing repetitive creasing along the skin surface. The synthesizing and manufacturing of SNAP-8 comprises a final freeze-drying step called lyophilization. Generally, the crystalline powder obtained due to freeze-drying is in the form of a polymorphous compound. It may be present in aggregates and show variation in the crystal size. However, this does not appear to lead to any chemical discrepancy in its composition. Extensive experimental studies have supported the homogeneity of this product. The usual shelf life of SNAP-8 is posited to be least 12 months, provided the compound is stored in a clean, cool, and dry place. If the compound is intended to be stored longer than a year, the temperature should be maintained at 4 degrees Celsius. This may extend the shelf life to approximately 18 months. Refrigeration of the SNAP-8 may potentially lead to its precipitation; however, this doesn’t appear to change the integrity of the compound.


OTHER KNOWN TITLES: Acetyl Glutamyl Heptapeptide-3


MOLECULAR WEIGHT: 1075.16 g/mol

SEQUENCE: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2

SNAP-8 Research

SNAP-8 and Wrinkle Depth
Research studies have suggested SNAP-8 may exhibit reduction capacity in the depth of wrinkles along the skin surface due to a possible resistance to contraction of the muscles. Some studies have suggested peptide exposure may lead to a decrease in wrinkle depth by as much as 30% with studies reporting SNAP-8 exposure for only one month.[3]  According to the researchers, “it is also worth to be remarked that in vitro assay highlighted an independent mechanism but synergistic effect between SNAP-8 and Leuphasyl, each one tested independently and resulting with 38% and 7% inhibition, respectively. In the trial, including both of them in equal concentrations (0.75 mM), a total inhibition value of 47% was observed.”

SNAP-8 and Botulinum Toxin
Botulinum toxin has been extensively studied and is commonly considered to restrict muscle contraction and thereby inhibit wrinkles. SNAP-8 appears to target the same wrinkle-forming mechanism via a differing mechanism of action. Botulinum toxin is considered to attack and break SNAP-25. This may lead to muscle paralysis, inhibiting muscle contraction.[4] SNAP-8 appears to capture the SNAP-25 protein, thereby destabilizing the SNARE complex. This is considered to lead to the inefficient release of neurotransmitters responsible for muscle contraction.[5] According to the researchers the peptide may potentially act by “preventing neuromuscular signal propagation, thereby eliminating wrinkles caused by over-stimulated neurons.”

SNAP-8 and Hydration, Anti-Oxidation
Like other comparable peptides, SNAP-8 appears to possess water-binding capacity.[6] Therefore, it may help the extracellular matrix of skin retain moisture. Alongside its possible hydration retaining characteristics, the peptide has been observed to exert protective impact against reactive oxygen species. Reactive oxygen species or free radicals are considered to have a major degenerative effect on skin cells.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Backardzhiev, Ilko, and Dona Filcheva. “Peptides in dermatocosmetics.” Journal of Varna Medical College 4.1 (2022): 45-49.
  2. Ji, Moongi, et al. “Method development for acetyl octapeptide-3 analysis by liquid chromatography-tandem mass spectrometry.” Journal of Analytical Science and Technology 11 (2020): 1-7.
  3. Errante F, Ledwoń P, Latajka R, Rovero P, Papini AM. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem. 2020;8:572923. Published 2020 Oct 30. doi:10.3389/fchem.2020.572923.
  5. Gutierrez, Luis M., et al. “A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells.” Journal of Biological Chemistry 272.5 (1997): 2634-2639.
  6. Avcil, Muhammet, et al. “Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study.” Journal of Cosmetic Dermatology 19.2 (2020): 328-337.
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This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

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11 reviews for SNAP-8 (Topical) (200mg)

  1. George Dante

    i have tried other peptide sources and they were hit and miss but ever since i switched to BP, never had any issue with quality.

  2. Katie Del

    easy peasy! no hassle at all! Was sent the correct product and happy there wasnt any mixups

  3. Li Westenfelt

    Love the site design and how they post updates articles on peptides and research! Super unique and different

  4. Jacqueline Telljohann

    fiable et aucun problème avec le shipping

  5. Ahmad Al Tawari

    منتج رائع ونقي ج

  6. Hayden Foster

    Been with them a year, have not had issues with their peptides.

  7. J.T. Asher

    Out of all the reps I have spoken to, I highly recommend Taylor! They can answer every question right there and then and get the job done if anything needs to be fixed or corrected in the order.

  8. Benjamin M.

    They were able to do an emergency shipment for me and overnight it free of charge even when I placed my order after 2!

  9. Doug gilmore

    As with everything right now prices are a bit high but they still are one of the best out there currently.

  10. Nathan Min

    Had to wait a while for this one to be stocked again so had to knock off a star.

  11. Farah Kamar

    Would recommened them to others for sure.

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