What Is SNAP-8 Peptide?
SNAP-8 is a potent anti-aging peptide that effectively relieves fine lines and facial wrinkles. A synaptosome-associated protein called SNAP-25 is responsible for muscle contraction that leads to the formation of wrinkles. The acetyl hexapeptide-3 mimics its peptide fragment and has an inhibitory effect on the action of SNAP-25. This has also been used extensively in various anti-aging formulations. The addition of two other amino acids in this hexapeptide forms acetyl octapeptide, which has a far more promising effect in treating facial wrinkles than Acetyl hexapeptide.
SNAP-8 competes with SNAP-25 for a position in the SNARE complex. After the attachment of SNAP-8, the SNARE complex is destabilized, causing the neurotransmitters are not released efficiently from the vesicles. This leads to an attenuation of muscle contraction and prevents the formation of facial wrinkles and lines.
The manufacturing of SNAP-8 comprises a final freeze-drying step. Generally, the crystalline powder obtained due to freeze-drying is in the form of a polymorphous compound. It may be present in aggregates and show variation in the crystal size. However, this does not lead to any chemical discrepancy in its composition. Extensive experimental studies have ensured the homogeneity of this product.
The product is generally available in two forms: SNAP-8 Powder and SNAP-8 Solution. SNAP-8 powder, an octapeptide powder, can easily be dissolved in water. The SNAP-8 Solution is available as an aqueous solution with a composition of 0.5/L of the powder form. This can be incorporated during the final manufacturing stage while maintaining the temperature below 40 degrees centigrade.
It is recommended to use a composition of SNAP-8 with a concentration ranging between 3 to 10 percent to obtain a significant effect of its anti-wrinkle property.
The usual shelf life of SNAP-8 Powder and SNAP-8 Solution is at least twelve months, provided the product is stored in a clean, cool, and dry place. If the product is intended to be stored longer than a year, the temperature should be maintained at 4 degrees Celsius for both forms. This can extend the shelf life to approximately eighteen months. Refrigeration of the SNAP-8 Solution can rarely lead to its precipitation; however, this doesn’t change the integrity of the product, and the efficacy remains essentially the same.
AKA: Acetyl Glutamyl Heptapeptide-3
MOLECULAR FORMULA: C41H70N16O16S
MOLECULAR WEIGHT: 1075.16 g/mol
PUBCHEM: CID 76283482
RESEARCH IMPLICATIONS OF SNAP-8
REDUCTION IN DEPTH OF WRINKLES
Research studies have indicated that SNAP-8 has promising results in reducing the depth of wrinkles present on the face due to the contraction of the muscles of facial expression. A profound effect has been seen on the wrinkles and feet of a cow’s forehead and eyes.
Some studies have confirmed a decrease in depth of wrinkles to as much as 30% with the usage of SNAP-8 for only one month of persistent use.
This leads to a smoother-looking face and younger skin.
A BETTER ALTERNATIVE TO BOTULINUM TOXIN
Botulinum toxin has been extensively used as an anti-aging agent and is commonly used to improve facial lines and wrinkles. However, SNAP-8 has a better safety profile compared to the botulinum toxin. It targets the same wrinkle-forming mechanism but in a different way.
Botulinum toxin also attacks SNAP-25 and breaks it. This leads to muscle paralysis that inhibits the formation of wrinkles due to muscle contraction. SNAP-8 captures the SNAP-25, thereby destabilizing the SNARE complex. This leads to the inefficient release of neurotransmitters responsible for muscle contraction. This state of muscle relaxation provides the basis for its application in the anti-wrinkle strategy.
Following are some properties of SNAP-8, making it a more suitable alternative than botulinum toxin.
• SNAP-8 is a milder formula compared to botulinum toxin and can be used topically.
• One of the most important benefits of SNAP-8 is its affordability. It is cheaper than botulinum toxin and thus can be used widely for cosmetic reasons and research purposes.
• It has a better safety profile as compared to botulinum toxin. Botulinum toxin can lead to severe hypersensitivity and a range of local and systemic side effects. SNAP-8 does not have these side effects.
RETENTION OF SKIN MOISTURE
Like all other peptides, it has a great water-binding capacity. Therefore, it helps the skin retain its moisture and looks plump and soft.
Reactive oxygen species or free radicals have a major degenerative effect on the skin and a major contributing factor toward age-related damage to the skin. SNAP-8, with its anti-oxidative effects, hydrating activity, and anti-wrinkle properties, provides a reassuring blend in the formulation of an age-defying cosmetic tool.
OTHER COSMETIC FORMULATIONS
SNAP-8 is used topically and thus can be used in several cosmetic forms such as gels, sera, emulsions, and creams. This proves important for its use in the cosmeceutical industry as an over-the-counter treatment for facial lines and wrinkles. The reduction of the depth of wrinkles and the removal of fine lines makes the skin look younger without any invasive cosmetic procedure.