AKA: Thymosin Beta 4
Molecular Formula: C212H350N56O78S
Molecular Weight: 4963.506 g/mol
PubChem: CID 16132341
CAS Number: 77591-33-4
What is TB-500 peptide (Thymosin Beta-4)?
is a synthetic analogue of the naturally occurring Thymosin Beta-4 peptide which ubiquitously exists in human and animal cells. The biologically effective peptide belongs to a ubiquitous family of 16 related molecules with a high degree of sequence conservation and localization in the majority of the tissues and circulating cells in the body. TB-500 sequesters and blocks actin polymerization in eukaryotic cells.
TB-500 expression increased four-six fold during early angiogenesis. It promotes the growth of new blood cells from the existing vessels. TB-500 mediates faster wound healing when injected subcutaneously and also promotes healing of muscle injury and development. TB-500 further catalyzes cellular migration through its interaction with actin cytoskeleton. The actin-binding domain happens to be a short central stretch of amino acid and is involved in TB-500 mediated regulation of blood cell division; wound healing, migration of endothelial cells and keratinocytes as well as higher production of extracellular matrix-degrading enzymes.
The peptide is one of the most effective wound healing molecules with anti-inflammatory properties. Thymosin Beta-4 unlike other growth factors helps in endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight which helps it to travel comparatively long distances through tissues. As mentioned before, it regulates the polymerization and function of actin.
Effects of Thymosin Beta-4 Peptide Demonstrated In Recent Studies
TB-500 peptide has been observed to mediate following functions in recent studies such as:
– Tissue repair
– Endothelial (blood vessels) cell differentiation
– Angiogenesis in dermal tissues
– Collagen deposition
– Keratinocyte movement
– Reduction in inflammation of tissue in joints
– Increase in muscle growth causing improvement in endurance and strength
– Relaxation of muscle spasm and improvement of muscle tone
– Increase in the intracellular exchange of substances
– TB-500 control of connective tissue flexibility
– Prevention of the formation of adhesions and fibrous bands in muscles, tendons and ligaments.
At present, its availability at Biotech Peptides is restricted only for academic and research use and not for clinical human administration.
Buy TB-500 peptide (Thymosin Beta-4), only if you are a licensed researcher.