Tripeptide-29 (200mg)

(12 customer reviews)


Tripeptide-29 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $179.55$170.10
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Tripeptide-29-200mg Category:



Tripeptide-29 is a synthesis of one of the basic components of collagen. Collagen is a long-chain polymer composed of short monomer repeats of three consecutive amino acids. These iterations combine to form a secondary structure, which forms tertiary and even quaternary structures. These complex structures have many potential emergent properties not typically found in peptide subunits. However, changes in the properties of peptide subunits may have an impact. Quaternary collagen compounds and collagen subunits most often follow the pattern of Gly-Pro-X or Gly-Xo-X or Gly-X-Hyp. Tripeptide-29 is a GlyPro Hyp peptide, a complete synthetic analog of common collagen building blocks.





Tripeptide-29 Research

Tripeptide-29 acts as a component of the larger collagen molecule. Its amino acid sequence and relative frequency may alter collagen molecules’ tertiary and quaternary properties with collagen superstructure. Collagen is a structural protein and plays a role in cell adhesion, tissue regulation, and repair. It is due to the multifaceted impacts of collagen that researchers have examined Tripeptide-29 in a wide range of research focus areas.

In vitro studies on Tripeptide-29 posit that the unpolymerized form of the peptide may be a partial agonist of the collagen receptor GPVI.[1] The scientists report that “The monomeric peptides partly inhibit the release of [3H]5-HT by CRP, suggesting that they are partial agonists of the collagen receptor GPVI.” GPVI appears to be expressed on the surface of platelets. Platelets are cell-like structures considered to be involved in the early formation of blood clots. GPVI receptors appear to play an important role in collagen-induced activation of platelet aggregation in vascular tissue, and are the first step toward blood clot formation and tissue repair. Therefore, collagen fibers are generally considered to be thrombus-forming. In the case of dysregulation, collagen thrombus formation may lead to thrombus formation. Interestingly, researchers suggested that in the course of cross-linking of Tripeptide-29, it appeared to promote GPVI activation, which may help understand how this peptide creates an “accurate” coagulation environment in a variety of bleeding/clotting disorders.

Tripeptide-29 and Collagen Stability
Benchtop studies on the role of short peptides such as Tripeptide-29 have suggested that they may extend certain regulatory action in collagen stability. In particular, research studies on Tripeptide-29 have helped scientists understand that the final structure of collagen appears to be primarily affected by the final peptide of the tripeptide monomer. The peptide at position C appears to have the greatest effect on the final collagen stability for ABC monomers.[2]

Tripeptide-29 and Collagen, Free Radical Damage
Free radical damage is a major cause of cell and tissue aging. Many defenses exist to guard against free radical damage, though the efficacy of certain endogenous defenses may decline over time. Studies on Namako have shown that collagen hydrolysates composed of monomers, such as Tripeptide-29, may be effective radical scavengers. The structure of tripeptide monomers may affect radical scavenger activity. No studies have been conducted on Tripeptide-29, but there is an appetite among researchers for studying how such peptides may be further employed.[3] For example, researchers report that “collagen hydrolysates from S. vastus can be used as a functional ingredient in food and nutraceutical products.”

Tripeptide-29 Regulates Tissue Fibrosis
In vitro studies of pigskin, cow skin, fish scales, and chicken feet, have observed that Tripeptide-29 may act as an inhibitor of dipeptidyl peptidase IV activity.[4] Dipeptidyl peptidase IV (DPP4) is primarily found in immune-infected cells. It is considered to be an essential part of the cell membrane, which indiscriminately destroys growth factors, chemokines, neuropeptides, and vasoactive peptides. It also appears to play a major role in glucose metabolism by decomposing incretin, a hormone that stimulates blood sugar levels. Animal studies have suggested that DPP4 may play a role in inducing fibrosis in organs such as the kidneys and liver via inhibition of the enzyme, which is considered to prevent scarring during the disease that affects these organs.[5] Tripeptide-29 may be doubly intriguing in this case, as the possible ability of Tripeptide-29 to stimulate glucose uptake and reduce fibrosis by inhibiting DPP4 opens the way for interesting avenues within the realm of diabetes research.

Tripeptide-29 and Skin Cells
Scientific interest has been generated in the role of Tripeptide-29 and other tripeptides in protecting skin cells from aging and cell death. Animal studies suggest that exposure to tripeptides may potentially reduce visible markers by improving contours, reducing skin cell deformity, and promoting hydration. Studies further suggest that tripeptides may reduce inconsistency in the texture of the skin barrier and may reduce the appearance of brown and red spots. In one particular study, 90% of research models were reported to exhibit increased hydration and flexibility due to improved elasticity, as compared to controls.[6][7]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Asselin J, Knight CG, Farndale RW, Barnes MJ, Watson SP. Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI. Biochem J. 1999 Apr 15;339 ( Pt 2)(Pt 2):413-8. PMID: 10191274; PMCID: PMC1220172.
  2. K. Mizuno, D. H. Peyton, T. Hayashi, J. Engel, and H. P. Bächinger, “Effect of the -Gly-3(S)-hydroxyprolyl-4(R)-hydroxyprolyl- tripeptide unit on the stability of collagen model peptides,” FEBS J., vol. 275, no. 23, pp. 5830–5840, Dec. 2008
  3. Abedin MZ, Karim AA, Latiff AA, Gan CY, Ghazali FC, Barzideh Z, Ferdosh S, Akanda MJ, Zzaman W, Karim MR, Sarker MZ. Biochemical and radical-scavenging properties of sea cucumber (Stichopus vastus) collagen hydrolysates. Nat Prod Res. 2014;28(16):1302-5. doi: 10.1080/14786419.2014.900617. Epub 2014 Mar 27. PMID: 24670209.
  4. Hatanaka T, Kawakami K, Uraji M. Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity. J Enzyme Inhib Med Chem. 2014 Dec;29(6):823-8. doi: 10.3109/14756366.2013.858143. Epub 2014 Mar 20. PMID: 24650211.
  5. Min HS, Kim JE, Lee MH, Song HK, Kang YS, Lee MJ, Lee JE, Kim HW, Cha JJ, Chung YY, Hyun YY, Han JY, Cha DR. Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction. Lab Invest. 2014 Jun;94(6):598-607. doi: 10.1038/labinvest.2014.50. Epub 2014 Mar 31. PMID: 24687121.
  6. Garre A, Martinez-Masana G, Piquero-Casals J, Granger C. Redefining face contour with a novel anti-aging cosmetic product: an open-label, prospective clinical study. Clin Cosmet Investig Dermatol. 2017 Nov 13;10:473-482. doi: 10.2147/CCID.S148597. PMID: 29180884; PMCID: PMC5691901.
  7. Reivitis A, Karimi K, Griffiths C, Banayan A. A single-center, pilot study evaluating a novel TriHex peptide- and botanical-containing eye treatment compared to baseline. J Cosmet Dermatol. 2018 Jun;17(3):467-470. doi: 10.1111/jocd.12542. Epub 2018 Apr 16. PMID: 29663676.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

Additional information


Biotech Peptides

12 reviews for Tripeptide-29 (200mg)

  1. Britt Baker

    Very professionally bottled and packaged.

  2. John Zarogoza

    This is my second vial & I will certainly be buying more!

  3. Tamara Qonita Mahadi

    I am in France and happy that theres no trouble with international shipping. Have had trouble before with recieving products. Im happy.

  4. Dylan Hansen

    Man, not much I can complain about. Any issues I’ve had has been with the post office so not really their fault.

  5. Anthony Buccanero

    The product is of good quality! Highly recommend

  6. Venera Meier

    Wasn’t expecting such a fast delivery! Very happy with it nontheless!

  7. Rory Nolan

    They are amazingly fast at sending out peptides for shipment!

  8. White Morgan

    They gave me a full refund when my peptides came in broken and shattered due to bad transit. I only needed one batch for a project but once it showed up in that state I decided to just scrap the project as it was just one to do on the side. Thanks!

  9. Roger A. Arbizu

    Real fast turnaround with them. Packages are always sent out in a timly matter and they’ll contact me if there are any issues.

  10. Sebastian King

    Just switched over to you guys! Been trying you and a few other peptide suppliers out and by far you guys have the best deals out there. The constant sales and discounts are a bonus as well.

  11. Nilay Shaw

    Highly recommend them if you’re doing research and need peptides in bulk!

  12. Arya shamie

    Overall happy with Biotech.

Add a review