Tripeptide-29 (topical) (200mg)

(12 customer reviews)


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5 - 95%$179.55
10 +10%$170.10
SKU: Tripeptide-29-200mg Category:


What Is Tripeptide-29?

Tripeptide-29 is a synthesis of one of the basic components of collagen. Collagen is a long-chain polymer composed of short monomer repeats of three consecutive amino acids. These iterations combine to form secondary structure, which forms tertiary and even quaternary structures. These complex structures have many emergent properties not found in peptide subunits. However, changes in the properties of peptide subunits can have an impact. The ultimate property of quaternary collagen compounds. Collagen subunits most often follow the pattern of Gly-Pro-X or Gly-Xo-X or Gly-X-Hyp. Tripeptide-29 is a GlyPro Hyp peptide, a complete synthetic analog of common collagen building blocks.





PUBCHEM: CID 11778669


What Does Tripeptide-29 Do?

Tripeptide-29 acts as a component of the larger collagen molecule. Its amino acid sequence and relative frequency can alter collagen molecules’ tertiary and quaternary properties with collagen superstructure. It is important to remember that collagen is a structural protein and plays a role in cell adhesion, tissue regulation, and healing. Therefore, Tripeptide-29 can affect a wide range of physiological properties.

The Roles of Collagen

For clarity, collagen is one of the most ubiquitous molecules in the animal kingdom. It is also found in humans, mammals, reptiles, fish, birds, and even algae. Collagen plays the roles in:
– Tendon and ligament structure
– Skin
– Vascular walls
– Cornea of the eye
– Muscle fibers
– Bone
– Teeth
– Scar formation
– Vitreous humor of the eye
– Placental structure
– Cartilage
– Transmembrane proteins like integrin and fibronectin
– Cell signaling

Tripeptide-29 Research

In vitro studies on Tripeptide-29 show that the unpolymerized form of the peptide is a partial agonist of the collagen receptor GPVI. GPVI is expressed on the surface of platelets. Platelets are cell-like structures involved in the early formation of blood clots. GPVI receptors play an important role in collagen-induced activation of platelet aggregation in vascular tissue and are the first step toward blood clot formation and tissue repair. Therefore, collagen fibers are generally considered to be thrombus-forming. In the case of dysregulation, collagen thrombus formation can lead to thrombus formation. Interestingly, cross-linking of Tripeptide-29 appears to promote GPVI activation, which may help understand how this peptide creates an “accurate” coagulation environment in a variety of bleeding/ clotting disorders.

Tripeptide-29 and Collagen Stability
Benchtop studies on the role of short peptides such as Tripeptide-29 have shown that they can regulate collagen stability. In particular, Tripeptide-29 helped scientists understand that the final structure of collagen is most affected by the final peptide of the tripeptide monomer. The peptide at position C has the greatest effect on the final collagen stability for ABC monomers. This discovery could help scientists make synthetic implants such as cartilage, bone, and teeth one day.

Collagen and Free Radical Damage
Free radical damage is a major cause of cell and tissue aging. The body has many defenses against free radical damage, which lose their effectiveness over time. Studies on Namako have shown that collagen hydrolysates composed of monomers, such as Tripeptide-29, are effective radical scavengers. The structure of tripeptide monomers may affect radical scavenger activity. No studies have been conducted on Tripeptide-29, but we are interested in investigating how such peptides can be used in foods and dietary supplements.

Tripeptide-29 Regulates Tissue Fibrosis
In vitro studies of pigskin, cow skin, fish scales, and chicken feet have shown that Tripeptide-29 is an inhibitor of dipeptidyl peptidase IV activity. Dipeptidyl peptidase IV (DPP4) is primarily found in immune-infected cells. Signal transduction and cell apoptosis Signal transduction and cell apoptosis. It is an essential part of the cell membrane. Indiscriminately destroys growth factors, chemokines, neuropeptides, and vasoactive peptides. It also plays a major role in glucose metabolism by decomposing incretin, a hormone that stimulates blood sugar levels.
Animal studies have shown that DPP4 plays a role in causing fibrosis in organs such as the kidneys and liver. Therefore, inhibition of the enzyme prevents scarring during the disease that affects these organs. Tripeptide-29 may be doubly useful in this situation, as diabetes is the leading cause of renal fibrosis. The ability of Tripeptide-29 to stimulate glucose uptake and reduce fibrosis by inhibiting DPP4 opens the way for many studies to control not only diabetes but also its pathological outcomes.

Tripeptide-29 and Skin Tone
There has recently been an interest in the role of Tripeptide-29 and other tripeptides in protecting the skin from the normal aging process. Animal studies suggest that topical application of tripeptides can reduce the visible effects of aging by improving contours, reducing skin deformity, and promoting hydration. There is also evidence that tripeptides can smooth the texture of the skin and reduce the appearance of brown and red spots. 90% of study participants showed improved skin hydration and increased flexibility due to improved elasticity. In combination with certain hexapeptides, topical Tripeptide-29 can promote skin regeneration and reduce fine lines, crow’s feet, bags under the eyes, and eye sockets. About 50% of subjects improved skin appearance in these animal studies when peptide paste was used twice daily.

All orders ship same day if placed by 2pm PST.  Peptides synthesized and lyophilized in the USA.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information


Biotech Peptides

12 reviews for Tripeptide-29 (topical) (200mg)

  1. Britt Baker

    Very professionally bottled and packaged.

  2. John Zarogoza

    This is my second vial & I will certainly be buying more!

  3. Tamara Qonita Mahadi

    I am in France and happy that theres no trouble with international shipping. Have had trouble before with recieving products. Im happy.

  4. Dylan Hansen

    Man, not much I can complain about. Any issues I’ve had has been with the post office so not really their fault.

  5. Anthony Buccanero

    The product is of good quality! Highly recommend

  6. Venera Meier

    Wasn’t expecting such a fast delivery! Very happy with it nontheless!

  7. Rory Nolan

    They are amazingly fast at sending out peptides for shipment!

  8. White Morgan

    They gave me a full refund when my peptides came in broken and shattered due to bad transit. I only needed one batch for a project but once it showed up in that state I decided to just scrap the project as it was just one to do on the side. Thanks!

  9. Roger A. Arbizu

    Real fast turnaround with them. Packages are always sent out in a timly matter and they’ll contact me if there are any issues.

  10. Sebastian King

    Just switched over to you guys! Been trying you and a few other peptide suppliers out and by far you guys have the best deals out there. The constant sales and discounts are a bonus as well.

  11. Nilay Shaw

    Highly recommend them if you’re doing research and need peptides in bulk!

  12. Arya shamie

    Overall happy with Biotech.

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