Tripeptide-29 (topical) (200mg)

Tripeptide-29

Tripeptide-29 is a synthesis of one of the basic components of collagen. Collagen is a long-chain polymer composed of short monomer repeats of three consecutive amino acids. These iterations combine to form a secondary structure, which forms tertiary and even quaternary structures. These complex structures have many potential emergent properties not typically found in peptide subunits. However, changes in the properties of peptide subunits may have an impact. Quaternary collagen compounds and collagen subunits most often follow the pattern of Gly-Pro-X or Gly-Xo-X or Gly-X-Hyp. Tripeptide-29 is a GlyPro Hyp peptide, a complete synthetic analog of common collagen building blocks.

Specifications

MOLECULAR FORMULA: C₁₂H₁₉N₃O₅

MOLECULAR WEIGHT: 285.3 g/mol

SEQUENCE: Gly-Pro-Hyp

Tripeptide-29 Research

Tripeptide-29 acts as a component of the larger collagen molecule. Its amino acid sequence and relative frequency may alter collagen molecules’ tertiary and quaternary properties with collagen superstructure. Collagen is a structural protein and plays a role in cell adhesion, tissue regulation, and repair. It is due to the multifaceted impacts of collagen that researchers have examined Tripeptide-29 in a wide range of research focus areas.

In vitro studies on Tripeptide-29 posit that the unpolymerized form of the peptide may be a partial agonist of the collagen receptor GPVI.^[1] The scientists report that “The monomeric peptides partly inhibit the release of [3H]5-HT by CRP, suggesting that they are partial agonists of the collagen receptor GPVI.” GPVI appears to be expressed on the surface of platelets. Platelets are cell-like structures considered to be involved in the early formation of blood clots. GPVI receptors appear to play an important role in collagen-induced activation of platelet aggregation in vascular tissue, and are the first step toward blood clot formation and tissue repair. Therefore, collagen fibers are generally considered to be thrombus-forming. In the case of dysregulation, collagen thrombus formation may lead to thrombus formation. Interestingly, researchers suggested that in the course of cross-linking of Tripeptide-29, it appeared to promote GPVI activation, which may help understand how this peptide creates an “accurate” coagulation environment in a variety of bleeding/clotting disorders.

Tripeptide-29 and Collagen Stability
Benchtop studies on the role of short peptides such as Tripeptide-29 have suggested that they may extend certain regulatory action in collagen stability. In particular, research studies on Tripeptide-29 have helped scientists understand that the final structure of collagen appears to be primarily affected by the final peptide of the tripeptide monomer. The peptide at position C appears to have the greatest effect on the final collagen stability for ABC monomers.^[2]

Tripeptide-29 and Collagen, Free Radical Damage
Free radical damage is a major cause of cell and tissue aging. Many defenses exist to guard against free radical damage, though the efficacy of certain endogenous defenses may decline over time. Studies on Namako have shown that collagen hydrolysates composed of monomers, such as Tripeptide-29, may be effective radical scavengers. The structure of tripeptide monomers may affect radical scavenger activity. No studies have been conducted on Tripeptide-29, but there is an appetite among researchers for studying how such peptides may be further employed.^[3] For example, researchers report that “collagen hydrolysates from S. vastus can be used as a functional ingredient in food and nutraceutical products.”

Tripeptide-29 Regulates Tissue Fibrosis
In vitro studies of pigskin, cow skin, fish scales, and chicken feet, have observed that Tripeptide-29 may act as an inhibitor of dipeptidyl peptidase IV activity.^[4] Dipeptidyl peptidase IV (DPP4) is primarily found in immune-infected cells. It is considered to be an essential part of the cell membrane, which indiscriminately destroys growth factors, chemokines, neuropeptides, and vasoactive peptides. It also appears to play a major role in glucose metabolism by decomposing incretin, a hormone that stimulates blood sugar levels. Animal studies have suggested that DPP4 may play a role in inducing fibrosis in organs such as the kidneys and liver via inhibition of the enzyme, which is considered to prevent scarring during the disease that affects these organs.^[5] Tripeptide-29 may be doubly intriguing in this case, as the possible ability of Tripeptide-29 to stimulate glucose uptake and reduce fibrosis by inhibiting DPP4 opens the way for interesting avenues within the realm of diabetes research.

Tripeptide-29 and Skin Cells
Scientific interest has been generated in the role of Tripeptide-29 and other tripeptides in protecting skin cells from aging and cell death. Animal studies suggest that topical exposure to tripeptides may potentially reduce visible markers by improving contours, reducing skin cell deformity, and promoting hydration. Studies further suggest that tripeptides may reduce inconsistency in the texture of the skin barrier and may reduce the appearance of brown and red spots. In one particular study, 90% of research models were reported to exhibit increased hydration and flexibility due to improved elasticity, as compared to controls.^[6][7]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References