Vialox (Pentapeptide-3V) (Topical) (200mg)

What is the Vialox (Pentapeptide-3V) peptide?

Vialox (topical), also known as Pentapeptide-3V, is a peptide sequence discovered in naturally produced snake venom. It appears to replicate the effects of botox by producing temporary muscular paralysis, reducing the appearance of fine lines and wrinkles. After 28 days of twice-daily treatment, a scientific study on animal models suggested that Vialox may eliminate wrinkles in about 50% of participants and skin roughness in around 47% of individuals.^[1] Vialox is a peptide derived from snake venom having five amino acid sequences (Gly-Pro-Arg-Pro-Ala). It appears to inhibit nicotinic acetylcholine receptors. This potential may enable it to have a curare-like effect at the neuromuscular junction, stopping nervous system electrical impulses from reaching the muscles and halting muscle contraction.

Specifications

Sequence: Gly-Pro-Arg-Pro-Ala

Molecular Formula: C21H37N9O5

Molecular Weight: 495.58 g/mol

PubChem: CID 67073230

Synonyms: Pentapeptide-3V

Reconstitution: Required

Vialox (Pentapeptide-3V) Research

Vialox (Pentapeptide-3V) and General Therapeutic Studies
Vialox (Pentapeptide-3V) is a peptide of interest to scientists because of its suggested propensity to disrupt nerve-muscle communication. Vialox, unlike other nicotinic acetylcholine receptors (AChR) antagonists, appears to operate solely on peripheral nicotinic acetylcholine receptors. According to animal studies, it has little impact on central neuronal receptors. Scientists posit that Vialox may be useful for cosmetic purposes and for treating spastic illnesses such as migraines, migraines, facial spasms, stress headaches, etc. Vialox appears to disrupt signal transmission between neurons and muscles.^[2] The researchers explain that “It is an antagonist of the acetylcholine receptor, and blocks nerves at the post-synaptic membrane, leading to muscle relaxation.” When a nerve’s axon releases acetylcholine, these signals are sent. Acetylcholine travels to the neuromuscular junction and binds to a receptor on the muscle, limiting sodium ion release. Depolarization (the cessation of electrical charge) will occur, resulting in the electrical pulse that creates wrinkles. As a result, it causes muscular contraction. Vialox has been studied for its apparent ability to halt this process by attaching to AChR. Vialox does not appear to elicit muscular contraction when combined with AChR, but it may prevent acetylcholine from binding. The overall effect is a decrease in acetylcholine binding as well as a decrease in the frequency and intensity of muscular contractions. This is the same effect found with various snake venoms, botulinum toxin injections, tubocurarine, curare toxin, and botox. Following the partial paralysis of the muscles that govern expression, forced relaxation occurs. This relaxation may aid in the reduction of wrinkles around the eyes, such as crow’s feet, as well as the expression of fine lines, on facial features and the forehead.

Vialox (Pentapeptide-3V) and Fine Lines, Wrinkles, Aging
Aging is an inevitable process in all organisms. The aging process of the skin includes a decline in the levels of skin cells, such as astrocytes. Astrocytes are responsible for the production of skin proteins like collagen. Natural aging also results in a decline in the levels of skin proteins like collagen and elastin. A decline in the levels of these proteins leads directly to physical markers of age, including wrinkles and fine lines. According to certain animal studies, Vialox has the potential to lower average skin roughness by 11%, and average relief by 8%. Because relief relates to wrinkle size, the peptide may diminish wrinkles by an average of 8%. These results were exhibited in 47% – 60% of the animal subjects examined across multiple studies. Researchers further suggest that Vialox is the most prevalent protein in skin collagen, consisting of lysine, threonine, and serine. These proteins appear to act directly in the skin’s dermis to increase collagen production while tightening the skin. Vialox, when used with other substances, has the potential to hasten skin tightening and lifting. According to studies conducted by medical specialists in the Department of Dermatology, anti-aging therapies including potential Vialox therapies, may enhance collagen growth and enhance skin compaction. According to Reddy et al. “this product is effective in smoothing periorbital, forehead and nasolabial fold expression wrinkles and provides an immediate tightening effect to the skin. Its recommended concentration is 0.05–0.3%.”^[3] Vialox’s potential to enhance collagen production in the skin may reverse physical signs of aging and minimize wrinkles.

Vialox (Pentapeptide-3V) and Potential Side Effects
According to scientific research, Vialox has the potential to suppress the production of acetylcholine. However, experts think that long-term use of Vialox might result in acetylcholine inhibition, resulting in acetylcholine buildup in the synaptic cleft, over-stimulation of nicotinic, and muscarinic ach receptors, and impaired neurotransmission. Agitation, muscular weakness, muscle fasciculations, miosis, hypersalivation, and sweating are signs of the aforementioned disorder.

Conclusion

Vialox (Pentapeptide-3V) is a peptide sequence inferred from natural proteins found in snake venom. It appears to be a potent antagonist of acetylcholine and may be incorporated into the production of cosmetics targeted at removing and preventing the prevalence of wrinkles, particularly on the forehead and around the eyes. It appears to reduce the depth of wrinkles following muscle contraction of facial expression. It may also function to decrease neuron excitability and regulates the secretion of acetylcholine. Regardless of the potential benefits associated with Vialox (Pentapeptide-3V), it is important to note that Vialox (Pentapeptide-3V) is a research chemical, limited to educational and scientific purposes—not for human consumption.

References