What Is Vialox (Pentapeptide-3V) (Topical)?
Vialox (also known as Pentapeptide-3V) is a peptide sequence discovered in snake venom. It replicates the effects of botox by producing temporary muscular paralysis, reducing the appearance of fine lines and wrinkles.
After 28 days of twice-daily treatment, a scientific study on animal models suggests that Vialox can eliminate wrinkles in about 50% of participants and skin roughness in around 47% of individuals.
Vialox is a peptide derived from snake venom having five amino acid sequences (Gly-Pro-Arg-Pro-Ala). It inhibits nicotinic acetylcholine receptors. This property enables it to have a curare-like effect at the neuromuscular junction, stopping nervous system electrical impulses from reaching the muscles and halting muscle contraction.
Molecular Formula: C21H37N9O5
Molecular Weight: 495.58 g/mol
PubChem: CID 67073230
Vialox (Pentapeptide-3V) Research
The Benefits of Vialox (Pentapeptide-3V)
Vialox (Pentapeptide-3V) is a peptide of interest to scientists because of its propensity to disrupt nerve-muscle communication. Vialox, unlike other nicotinic acetylcholine receptors (AChR) antagonists, operates solely on peripheral nicotinic acetylcholine receptors. According to animal studies, it has little impact on central neuronal receptors.
Scientists think Vialox may be useful for cosmetic purposes and for treating spastic illnesses such as migraines, migraines, facial spasms, stress headaches, etc.
Vialox disrupts signal transmission between neurons and muscles. When a nerve’s axon releases acetylcholine, these signals are sent. Acetylcholine travels to the neuromuscular junction and binds to a receptor on the muscle, limiting sodium ion release. Depolarization (the cessation of electrical charge) will occur, resulting in the electrical pulse that creates wrinkles. As a result, it causes muscular contraction. Vialox halts this process by attaching to AChR. Vialox does not elicit muscular contraction when combined with AChR, but it does prevent acetylcholine from binding.
The overall effect is a decrease in acetylcholine binding as well as a decrease in the frequency and intensity of muscular contractions. This is the same effect found with various snake venoms, botulinum toxin injections, tubocurarine, curare toxin, and botox.
Following the partial paralysis of the muscles that govern expression, forced relaxation occurs. This relaxation may aid in the reduction of wrinkles around the eyes, such as crow’s feet, as well as the expression of fine lines, such as those that are forehead-sensitive.
The Effects of Vialox on Fine Lines and Wrinkles and its Role in Aging
Aging is an inevitable process. The aging process of the skin includes a decline in the levels of skin cells like astrocytes. Astrocytes are responsible for the production of skin proteins like collagen. Aging also results in a decline in the levels of skin proteins like collagen and elastin. A decline in the levels of these proteins leads to the signs of aging like wrinkles and fine lines.
According to animal studies, Vialox can lower average skin roughness by 11% and average relief by 8%. Because relief relates to wrinkle size, Vialox can diminish wrinkles by an average of 8%. These were seen in between 47-60% of the animal subjects examined.
According to scientific studies, Vialox is the most prevalent protein in skin collagen, consisting of lysine, threonine, and serine. It works directly on the skin’s dermis to increase collagen production while tightening the skin. Vialox, when used with other substances, can hasten skin tightening and lifting.
According to studies conducted by medical specialists in the Department of Dermatology, anti-aging medicines such as Vitamin A demonstrate that Vialox can enhance collagen growth, hence enhancing skin compaction. Vialox can enhance collagen production in the skin, reversing aging and minimizing wrinkles.
The Adverse Effects of Vialox
According to scientific evidence, Vialox can suppress the production of acetylcholine. However, experts think that long-term use of Vialox might result in acetylcholine inhibition, resulting in acetylcholine buildup in the synaptic cleft, over-stimulation of nicotinic, and muscarinic ach receptors, and impaired neurotransmission.
Agitation, muscular weakness, muscle fasciculations, miosis, hypersalivation, and sweating are signs of the aforementioned disorder. These are only a few of the side effects of Vialox, and a study is currently being conducted to discover the others.
Vialox (Pentapeptide-3V) is a peptide sequence inferred from snake venom. It is a potent antagonist of acetylcholine. It can be incorporated into the production of cosmetics targeted at removing and preventing the prevalence of wrinkles, particularly on the forehead and around the eyes. It reduces the depth of wrinkles following muscle contraction of facial expression. It also functions to decrease neuron excitability and regulates the secretion of acetylcholine.
Regardless of the numerous benefits associated with Vialox (Pentapeptide-3V). It is important to note that Vialox is a research chemical or peptide, limited to educational and scientific purposes—not for human consumption.