Vialox (Pentapeptide-3V) (200mg)

Vialox (Pentapeptide-3V) Peptide

Vialox, also known as Pentapeptide-3V, is a peptide sequence discovered in naturally produced snake venom. It appears to replicate the action seen in paralytic compounds such as botulinum toxin by producing temporary muscular paralysis, and thereby potentially reducing wrinkle depth. After 28 days of twice-daily exposure, a scientific study on animal models suggested that Vialox may eliminate wrinkles in 50% and skin roughness in around 47% of study subjects.^[1] Vialox is a peptide derived from snake venom having five amino acid sequences (Gly-Pro-Arg-Pro-Ala). It appears to inhibit nicotinic acetylcholine receptors. This potential may enable it to have a curare-like effect at the neuromuscular junction, stopping nervous system electrical impulses from reaching the muscles and halting muscle contraction.

Specifications

Sequence: Gly-Pro-Arg-Pro-Ala

Molecular Formula: C₂₁H₃₇N₉O₅

Molecular Weight: 495.58 g/mol

PubChem: CID 67073230

Synonyms: Pentapeptide-3V

Vialox Peptide Research

Vialox (Pentapeptide-3V) and General Studies
Vialox (Pentapeptide-3V) is a peptide of interest to scientists because of its suggested propensity to disrupt nerve-muscle communication. Vialox, unlike other nicotinic acetylcholine receptors (AChR) antagonists, appears to operate solely on peripheral nicotinic acetylcholine receptors. According to animal studies, it may have little impact on central neuronal receptors. Scientists posit that Vialox may be impactful within the context of certain spastic issues such as migraines and spasms, etc. Vialox appears to disrupt signal transmission between neurons and muscles.^[2] The researchers explain that “It is an antagonist of the acetylcholine receptor, and blocks nerves at the post-synaptic membrane, leading to muscle relaxation.” When a nerve’s axon releases acetylcholine, these signals are sent. Acetylcholine travels to the neuromuscular junction and binds to a receptor on the muscle, limiting sodium ion release. Depolarization (the cessation of electrical charge) may occur, resulting in the electrical pulse that creates a wrinkle. As a result, it causes muscular contraction. Vialox has been studied for its proposed ability to halt this process by attaching to AChR. Vialox does not appear to elicit muscular contraction when combined with AChR, but it may prevent acetylcholine from binding. The overall effect is a decrease in acetylcholine binding as well as a decrease in the frequency and intensity of muscular contractions. This is the same effect considered to be induced by botulinum toxin, tubocurarine, and curare toxin. Following the partial paralysis of the muscles, forced relaxation occurs.

Vialox (Pentapeptide-3V) and Wrinkles
The aging process of the skin includes a decline in the levels of skin cells, such as astrocytes. Astrocytes are responsible for the production of skin proteins like collagen. Natural aging also results in a decline in the levels of skin proteins like collagen and elastin. A decline in the levels of these proteins leads directly to physical markers of age, including wrinkles. According to certain animal studies, Vialox has the potential to lower average skin roughness by 11%, and average relief by 8%. Because relief relates to wrinkle size, the peptide may diminish wrinkles by an average of 8%. These results were exhibited in 47% – 60% of the animal subjects examined across multiple studies. Researchers further suggest that Vialox is the most prevalent protein in skin collagen, consisting of lysine, threonine, and serine. These proteins appear to act directly in the epidermis to increase collagen production while tightening the skin. Vialox, when introduced as an adjunct to other substances, may increase the potential of hastening skin protein production. According to studies conducted by specialists in the Department of Dermatology, Reddy et al. noted “this product is effective in smoothing periorbital, forehead and nasolabial fold expression wrinkles and provides an immediate tightening effect to the skin. Its recommended concentration is 0.05–0.3%.”^[3]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

References