Fitness-conscious people often face the challenge of losing fat from the abdomen. Even strict food regimes and exercise do not help to lose truncal obesity. With the advancement of medical knowledge, a new peptide called Tesamorelin is now available to help overcome stubborn fat with minimal adverse effects on the body.

What is Tesamorelin?

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) and comprises 44 amino acids and a trans-3-hexenoic acid group. The peptide promotes weight loss and can be used only with medical recommendation.  Theratechnologies was the first organization that manufactured the peptide with the brand name EGRIFTA.

The importance of growth-hormone-releasing-hormone

The hypothalamus in the brain secretes GHRH. The hypothalamus is a significant gland that regulates diverse physiological functions, including hormonal release and regulation of body temperature. The secreted GHRH, in turn, stimulates the release of growth hormone (GH) from the pituitary gland of our body.

The efficiency of the peptide depends on the amino acid composition of GHRH combined with 3-hexanoic acid moiety. The moiety works like a plant metabolite and hence is safe for ingestion. Tesamorelin was approved for use in November 2010. The peptide helps to lose fat in HIV patients as the antiretroviral substances often induce lipodystrophy. Bodybuilders and fitness enthusiasts also use it to lose abdominal fat regularly. 

How does Tesamorelin work?

The peptide, just like its natural counterpart, promotes the release of GH from the pituitary gland. GH promotes lipolysis or metabolism of stored lipids and triglycerides in the body. Lipids and triglycerides are versions of fat stored in our bodies for a future energy source. Hence high levels of the either increase risk of cardiac disease. Tesamorelin reduces visceral fat around the abdomen. Studies on HIV patients with lipodystrophy show that the molecule can reduce abdominal fat by about seventeen percent within twenty-six weeks. It also decreases liver fat up to eighteen percent.

The recommended dose of Tesamorelin in an average adults is 2 mg each day. It can be injected beneath the naval region while avoiding any region of scarring or bruising. The peptide should be used immediately upon reconstitution. The lyophilized peptides can be stored between 36 and 46 degrees Fahrenheit. The peptide solution should be used only if it is clear and free of particles upon reconstitution.

Other Lesser Known Benefits of Tesamorelin

The peptide not only improves the body’s natural ability to secrete GH but also has far fewer side effects compared to other GHRH secretagogues. The peptide reduces belly fat as well as confers additional benefits. It has been found to improve cognitive function in individuals aged between 55 and 87 during the course of administration of the peptide.

Side Effects of Using Tesamorelin

Tesamorelin has been found to be potentially safe for human consumption. However, it is important to be cognizant of the mild side effects which have been observed. These side effects are as follows:
– Redness, swelling, or irritation at the site of injection.
– Muscle pain
– Nausea or vomiting
– Sweating
– Mild itchiness

The peptide might have cross-reactivity with certain drugs. Hence medical consultation is crucial before the use of the molecule. Cholesterol medications such as Zocor and HIV-antiretroviral medication such as Norvir can show adverse effects when used with the peptide.

Other Things to Consider

Tesamorelin cannot be used by pregnant women or by those who are planning to conceive. Visceral fat is required for pregnancy. The peptide promotes fat metabolism and thus is unsuitable during pregnancy. Medical consultation is also recommended for the use of the molecule for diabetic patients. It increases the levels of insulin growth factor 1 (IGF-1). This can lead to fluctuations in blood sugar levels. Such a situation will demand constant monitoring of blood sugar.

In a nutshell, Tesamorelin turns out to be a wonder peptide for fitness enthusiasts and bodybuilders. It helps in the metabolism of difficult abdominal fat and helps to achieve fitness goals faster. By triggering the release of growth hormone, it improves the body’s general metabolism and energy homeostasis. The peptide has diverse beneficial influences, such as enhancing cognitive capabilities with only minimal side effects. The amino acid composition and the hexanoic acid modification confers the beneficial functions to the peptide similar to growth hormone-releasing hormone. In fact, the short stretch of the peptide helps to overcome the adverse effects of excess full-length GHRH. However, the peptide has to be used upon medical recommendation only and is not recommended for pregnant ladies and diabetic patients.


Disclaimer: The products mentioned are not for human or animal consumption. All the information shared in this article is for educational purposes only.

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