CJC-1295 & GHRP-6 in Regards to Nervous Tissue Protection

by | May 30, 2022 | Research

CJC-1295 and GHRP-6 Blend

CJC-1295 and GHRP-6 blend work together to stimulate the increase of GH. The increase in GH levels due to this blend is higher than using either of these peptides alone. GHRP-6 also improves appetite and sleep quality. CJC-1295 and GHRP-6 blend improves overall well-being, wound healing, and nervous tissue growth.


What is CJC-1295?

CJC-1295 is a synthetic derivative of the naturally occurring growth hormone-releasing hormone (GHRH). It is a modified sequence of the first 29 amino acids in the GHRH that is part of the growth hormone secretagogues group. This group acts on the anterior pituitary and causes growth hormone release. CJC-1295 is somewhat similar to sermorelin but varies from other growth hormone secretagogues. An additional compound called the drug affinity complex, or DAC, attaches to the structure of the peptides via a lysine linker. This complex protects the peptide from hydrolysis during its circulation in the bloodstream and, at the same time, promotes its binding to albumin, which allows it to have a longer and more stable half-life in comparison to other such compounds.


CJC-1295 and Growth Hormone Release

Since CJC-1295 is a growth hormone secretagogue, it should not come as a surprise that it causes the stimulation of growth hormone release from the anterior pituitary. Studies conducted on lab rats have shown that the administration of a single dose of CJC-1295 can boost growth hormone by up to two to ten times. Causing a peak in the growth hormone concentration after two hours of administration ensures that it remains for 6 to 10 days.

However, one key factor differentiating CJC-1295 from other growth hormone secretagogues is that it affects the hormone release purely physiologically. Its administration allows the achievement of the usual peaks and valleys seen in the growth hormone release during the normal circadian rhythm. But meanwhile, it also blocks the rise in the growth hormone level to the extent that it can cause side effects. Therefore, CJC-1295 is known for its physiological effect on growth hormone release, which helps benefit from its functions without worrying about its side effects.

It has been observed that CJC-1295 administration positively influences all of the effects of growth hormones, such as protein synthesis, fat metabolism, blood sugar regulation, growth (via hypertrophy and hyperplasia), preservation of myocardial function, and bone density.


CJC-1295 and Growth

Studies on mice with GHRH deficiency showed that CJC-1295 administration is the normal physiology of GHRH release. CJC-1295 causes a pulsatile increase in GH levels. This makes it an eligible candidate for the therapy of growth hormone deficiency and related disorders.


CJC-1295 and Infertility

Some research from the early 1990s has hinted at the possibility that CJC-1295 might help treat infertility in women. This possibility is because IGF-1 regulates ovulation. CJC-1295 also regulates the IGF-1 via its stimulation of growth hormone release, and researchers can test it in a lab setting for ovulation induction and even sperm production and maturation.


What is GHRP-6?

GHRP-6 is a growth hormone secretagogue that binds to the ghrelin receptors and causes growth hormone release by activating these receptors. This peptide, consisting of a sequence of 6 amino acids in its structure, has been implicated in various clinical settings and conditions such as scar formation, memory, cognitive function, protection of the heart, improvement of sexual health, and Parkinson’s Disease.


Effect of GHRP-6 on Memory

GHRP-6 improves cognitive function and memory by increasing physical activity. Although this mechanism of action is not quite well understood, it is said that there is a reason to believe that exercise and physical activity improves learning and memory, especially if it is done following a task. Research on lab rats has shown that GHRP administration solidified long-term memory and converted short-term memories into long-term ones by improving blood flow to different brain regions.


Protection of Brain Tissue

Significant evidence suggests that GHRP-6 administration protects neurons and other nervous tissues by inactivating apoptotic pathways and improving blood flow, thus preventing ischemic death.


Improvement of Skin Appearance by Reducing Scar Formation

Research indicates that GHRP-6 improves the appearance of the skin and reduces scarring by increasing the deposition of extracellular matrix proteins and collagen, thereby improving scar formation.

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