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Fragment 176-191 & CJC-1295 & Ipamorelin Blend (12mg)
Fragment 176-191 & CJC-1295 & Ipamorelin Blend are Synthesized and Lyophilized in the USA.
Discount per Quantity
|Quantity||5 - 9||10 +|
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
Fragment 176-191 Specifications
AKA : Frag 176-191
Molecular Formula : C78H125N23O23S2
Molecular Weight : 1817.1 g/mol
Sequence : Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe
CAS Number : 66004-57-7
Reconstitution : Required
Molecular Formula: C152H252N44O42
Molecular Weight: 3647.954 g/mol
PubChem: CID 56841945
Other: DOES NOT CONTAIN DAC
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85 g/mol
PubChem: CID 9831659
CAS Number: 170851-70-4
Potential of Fragment 176-191 & CJC-1295 & Ipamorelin Peptide Blend
Studies in animal models have suggested the efficacy of Fragment 176-191, a short stretch of human growth hormone (HGH), in promoting fat mobilization and triggering a metabolic shift towards the perpetuation of lean body mass. It appears to further lack the side effects of hGH such as long-bone growth, reduced sensitivity to insulin, edema, and promotes cartilage regeneration. It has been reported by researchers to boost the body’s natural immune system and metabolic processes. The peptide fragment has also been observed to promote GH secretion by regulating physiological processes involved in GH synthesis. The scientifically-studied potential of Fragment 176-191 include effective fat burning via increased lipolysis and decreased lipogenesis and adequate energy levels. It does not appear to significantly alter glucose tolerance, insulin sensitivity, or IGF-1 levels, though more research is needed to validate any claims. Fragment 176-191 may also play a role in benefiting the treatment of other diseases, beyond it’s potential in obesity therapy. Potential areas of research include using Fragment 176-191 as a treatment option for prediabetes and diabetes. Due to its supposed cartilage regeneration abilities, experts may also consider it in adjunctive therapy for osteoarthritis treatment.
CJC-1295 is another synthetic GH releasing hormone. It appears to promote the production of GH and can be used as an alternative for Fragment 176-191 concerning GH synthesis. CJC-1295 has been primarily researched for its anti-aging potential. CJC-1295 may improve basal as well as highest physiological levels of GH. It may further increaase the availability of free GH in plasma. Numerous studies have suggested that CJC-1295 has helped reduce weight and attain a healthier body. CJC-1295 also appears to have healing properties due to its possible cell replication and regeneration abilities. Only the freely available GH happens to be functional in the body. The use of CJC-1295 thus may help to adjust the natural physiological reaction to Fragment 176-191. Therefore, Fragment 176-191 may potentially be used by the body for its other benefits without altering the physiological levels of GH. Therefore, by regulating growth hormone production in the body, CJC-1295 may possibly benefit the ill effects of aging attributed to decreased growth hormone production in the body. Studies have suggested that it may improve injury recovery time and possess beneficial effects on sleep and cognitive function.
Ipamorelin is a peptide that apparently functions as an agonist for the GH secretagogue receptor. It may be administered in combination with Fragment 176-191 and CJ-1295 to potentially enhance the secretion of GH and maximize its physiological level. Animal studies have suggested Ipamorelin to be beneficial in regulating insulin and bone mineralization. The researchers reported that it “stimulates insulin release through the calcium channel and the adrenergic receptor pathways.” Thus, the main effects of Ipamorelin could be on the pancreatic tissue, where it may increase insulin production, release of the ghrelin hormone, and increase cell synthesis. It has been suggested to have numerous other beneficial effects as well. These include the promotion of fat loss, increased testosterone production, improved sexual health, bone strength, and body temperature regulation. Interestingly, it appears to mediate an immediate short-term response, causing a rapid GH release. CJC-1295, by contrast, appears to exercise a long-term influence by enhancing GH secretion over an extended duration and helps maintain standard physiological secretion patterns of GH. Having a half-life of just 2 hours, Ipamorelin may be cleared more rapidly from the body. Keeping in view the pharmacokinetics of the two peptides, researchers have studied them in combination to ensure a rapid response (attributed to Ipamorelin) and long-lasting effects (owing to CJC-1295).
- Ng FM, Sun J, Sharma L, Libinaka R, Jiang WJ, Gianello R. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000;53(6):274-8. doi: 10.1159/000053183. PMID: 11146367.
- Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.]
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
- Van Hout MC, Hearne E. Netnography of Female Use of the Synthetic Growth Hormone CJC-1295: Pulses and Potions. Subst Use Misuse. 2016 Jan 2;51(1):73-84. doi: 10.3109/10826084.2015.1082595. Epub 2016 Jan 15. PMID: 26771670.
- Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
- Gobburu JV, Agersø H, Jusko WJ, Ynddal L. Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers. Pharm Res. 1999 Sep;16(9):1412-6. doi: 10.1023/a:1018955126402. PMID: 10496658
Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.
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