support@biotechpeptides.com
Fragment 176-191 (10mg)

Fragment 176-191 (10mg)

(71 customer reviews)

$67.00

Fragment 176-191 peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$63.65$60.30

Out of stock

SKU: Fragment-176-191-10mg Category:

Description

Fragment 176-191 Peptide

Fragment 176-191 peptide (Frag 176-191) is a short growth hormone fragment, sometimes called the “lipolytic fragment.” The name was coined from initial research on animal models, which suggested that Fragment 176-191 holds the potential to enhance fat metabolism in genetically engineered obese murine models. Unfortunately, growth hormone in its full form (hGH) may suppress carbohydrate metabolism, alter sensitivity towards insulin, promote long bone growth, and heighten insulin-like growth factor-1 (IGF-1) levels. Extensive animal studies have suggested that the synthetic fragment may enhance the lipolytic action of growth hormone, potentially without inducing these aforementioned ancillary impacts.[1] The peptide is also available in 5mg.

Specifications

Other Known Titles: Frag 176-191

Molecular Formula: C78H125N23O23S2

Molecular Weight: 1817.1 g/mol

Sequence: Tyr-Leu-Arg-Ile-Val-Gin-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe

Fragment 176-191 Research

Fragment 176-191 and Structure
Fragment 176-191 is a small segment derived from the growth hormone (hGH), consisting of 16 amino acids. This segment represents the terminal 16 amino acids of the hGH molecule, which is hypothesized to function as the “lipolytic fragment” of hGH. The term “lipolytic” suggests that this fragment possesses attributes that promote the breakdown of fats. To potentially enhance the stability of this peptide, the initial amino acid in the sequence of hGH Fragment 176-191 has been substituted with tyrosine. Consequently, this modified peptide is also referred to as Fragment tyr-hGH 177-191 or AOD 9604. The addition of tyrosine at the N-terminus is believed to increase the peptide’s stability. Moreover, there is suggestive data of a naturally occurring disulfide bond formed between two cysteine amino acids within both the original hGH and the hGH Fragment 176-191. This disulfide bond likely contributes to the structural integrity of the molecule, potentially enhancing its durability and ability to withstand degradation in various conditions, including exposure to stomach acids.[2]

Fragment 176-191 and Fat Cells
The fat cell dissolution potential of Fragment 176-191 stems from the peptide’s potential to increase the production of beta-3 adrenergic receptors (3-AR or ADRB3). The presence of an increased number of beta-3 adrenergic receptors on the surface of adipocytes, or fat cells, may enhance the cells’ responsiveness to lipolytic signals. This suggests that even if Fragment 176-191 does not directly engage beta-3 adrenergic receptors, the augmented receptor density may potentiate the inherent lipolytic response to endogenous catecholamines such as adrenaline, which are believed to directly stimulate these receptors. Additionally, Fragment 176-191 may potentially activate other cellular signaling pathways that indirectly promote fat metabolism. For instance, it might affect mechanisms that either increase the expression of enzymes critical to the lipolysis process, or augment the cellular response to lipolytic signals by modulating the activity of secondary messengers within the cell. In this context, lipolysis refers to the breakdown of fats within the adipocytes, primarily facilitated by lipolytic enzymes. Secondary messengers are molecules inside cells that amplify the signals from receptors on the cell surface to the biochemical machinery inside. This process is essential for coordinating complex cellular responses to external stimuli.

Research indicates that genetically modified mice that lack ADRB3 may be resistant to the action of hGH / Fragment 176-191, suggesting that this may indeed be the primary mechanism. In contrast, potential actions on lipolytic enzymes may play a secondary role.[2] One experimental study observed that Fragment 176-191 exposure appeared to cause up to 50% weight reduction in obese mice over three weeks. Interestingly, the peptide appeared to mediate weight reduction only in obese mice but not in lean mice during the same span of exposure. The results suggest that there may be secondary pathways involved in energy homeostasis, which may be capable of maintaining fat reserve in lean mice by overriding ADRB3 pathway.[3]

In the scientific community, further examination of this subject has been undertaken through controlled clinical experiments, notably the METAOD005 study. This particular study was designed to evaluate the potential adipose tissue reduction action of the peptide over a 12-week duration. Initial results appear to indicate that one of the Fragment 176-191 groups may have shown a significant decrease in body mass, with an average loss of around 5.7 pounds. Additionally, it was proposed that this peptide might also benefit lipid and glucose metabolism parameters, but more research is needed to fully investigate these hypotheses.[4]

Fragment 176-191 and Hypoglycemia
The C terminal end of hGH principally has been considered to bring about hypoglycemic (low blood sugar) levels in the bodies of murine models. Screening of at least six different fragments obtained from the C terminal section of hGH has suggested that Fragment 176-191 may be an active synthetic derivative of hGH in research on blood sugar control. The hypoglycemic potential is secondary to maintaining an increased expression of insulin in blood plasma.[4]

Fragment 176-191 and Cartilage
Experimental research in Fragment 176-191 suggests its potential in cartilage regeneration. Researchers engaged in the study of synthetic peptides suggest that they may bring about cartilage regeneration through hyaluronic acid. Research in rabbits has observed that weekly exposure to Fragment 176-191 appeared to improve cartilage growth (within laboratory measures), and its co-introduction with hyaluronic acid (HA) appeared to be even more impactful.[5]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Habibullah MM, Mohan S, Syed NK, Makeen HA, Jamal QMS, Alothaid H, Bantun F, Alhazmi A, Hakamy A, Kaabi YA, Samlan G, Lohani M, Thangavel N, Al-Kasim MA. Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells. Drug Des Devel Ther. 2022 Jun 27;16:1963-1974. doi: 10.2147/DDDT.S367586. PMID: 35783198; PMCID: PMC9249349.
  2. Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522. PMID: 11713213.
  3. Heffernan MA, Jiang WJ, Thorburn AW, Ng FM. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E501-7. doi: 10.1152/ajpendo.2000.279.3.E501. PMID: 10950816.
  4. Ng FM, Bornstein J. Hyperglycemic action of synthetic C-terminal fragments of human growth hormone. Am J Physiol. 1978 May;234(5):E521-6. doi: 10.1152/ajpendo.1978.234.5.E521. PMID: 645904.
  5. Kwon DR, Park GY. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 Summer;45(4):426-32. PMID: 26275694.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Dr. Usman

Dr. Usman (BSc, MBBS, MaRCP) completed his studies in medicine at the Royal College of Physicians, London. He is an avid researcher with more than 30 publications in internationally recognized peer-reviewed journals. Dr. Usman has worked as a researcher and a medical consultant for reputable pharmaceutical companies such as Johnson & Johnson and Sanofi.

Additional information

Brand

Biotech Peptides

71 reviews for Fragment 176-191 (10mg)

  1. Ava Lee –

    High-quality products & fast shipping!

  2. Aspen Sanders –

    I love this company

  3. Charlie Green –

    Legit products and quality company. I am very pleased with my experience so far

  4. Ava Lee –

    Keep up the good work

  5. Ana White –

    This same product goes for about 5 times as much at a compounding pharmacy. 5/5!

  6. Mildred Adamson –

    Great products.
    Fast shipping.
    5 stars for everything.

  7. Corbyn Ezra –

    Overall great experience with Biotech Peptides. Despite confusion at the start and a little struggle getting one of my prodcuts, they were kind enough to send 2 free-of-charge products along with my missing one!

  8. Odessa Burton –

    I have ordered from Biotech Peptides a few times over the last year and they are always super quick delivering! You get text message updates about your order too. If you sign up for the newsletter you get discount codes regularly – Great job guys! Keep it up

  9. Archie Holmes –

    Great service and quality stuff what more could you want!!!

  10. Dexter Webb –

    USPS lost my package but I was sent a replacement. Free of charge! 4 stars for the delay even though I realize its not your fault/

  11. Tyra Campbell –

    Amazing!

  12. Carlo Melwani –

    Shipping is fast and reasonably priced.

  13. Deven Krantz –

    Lots of information on their website to help find what you need. I have even bought or looked into peptides I was never interested in as well interested of it. It’s opened my curiosity to a new realm of research as well. Looking forward to working with topical options too!

  14. Kalyn Nicholson –

    Everything I’ve ordered has been good quality so far.

  15. Russel Banks –

    Prompt service

  16. Stephen Webb –

    I’ve placed a bunch of orders with Biotech so far and have never had any issues. A quick turnaround and a good product. I guess I have been fortunate and have not run into issues with peptides being out of stock, they usually have everything I need when it is time for repurchase.

  17. Elizabeth Greg –

    One of the most affordable places to get peptides! They also have some items on sale here and there. Even better is they offer deals when buying in bulk.

  18. Travis Edrington –

    Best customer service and products I have ever had. And I have been a customer with other peptide sites before.

  19. Craig Osborne –

    the promotions they send from time to time are great

  20. Halie Martin –

    Just made my third order in 2 months! wish the sizes were a bit bigger! But they have good quality peptides.

  21. Richard Wilson –

    Been with them for a while. Had got a promtoional email from them so decided to try them out. Their stuff checks out and They’re good at sending our promotions and have frquent sales.

  22. jacob harvey –

    Give them two thumbs up

  23. Ben Kennedy –

    I have been a loyal cutsomer since July and I can say this is the first time I was sent a broken vial. After inspecting it I’m not sure if it happened when packaging or during transit. I called them and spoke to Danny who was extremly helpful. They did not even ask me for any kid of proof and they just explained to me that I should be getting a new confirmation email with a new order shortly. And due to the headache they even threw in a disocunt code for the next few orders. Such a great company in every way.

  24. PK Lewis –

    Like the disocunts they send out periodically!

  25. james messar –

    The customer service provided is unmatched. My order came in this morning and even though the box clearly says “FRAGILE” the carrier mishandelded it. All my peptides were broken except a few here and there. I took a picture and emailed it to biotech and immediatly got a responce from Danny. They apologised even though it was not their fault and put in a rush order for me. The tracking number says I should be recieving it by tomorrow morning so fingers crossed.

  26. pete newman –

    My peptides showed up in perfect condition. Vials were all in their box and were packaged safley.

  27. Kyle Edwards –

    Got a disocunt code for my one year of buying with them!

  28. Alex Avila –

    Searched for this product for a while and this is the only company that sells a qualitative and unaltered one.

  29. Taylor Taylor –

    This is the best place to buy peptides, especially in bulk as they’re in stock with everything most of the time.

  30. Nick Perez –

    La mejor compañía de péptidos. lo recomiendo con confianza

  31. Shawn Lachman –

    Never had a better shopping experience than with Biotech

  32. Lupe Ortiz –

    Customer service lived up to my expectation. It seems their was an issue with their site and they had a product on sale that was not supposed to be on sale. Customer service contacted me to let me know the mix up but that they would honor the sale prices listed this one time.

  33. Ruich Gillet –

    The customer service of this company is second to none.

  34. Steven Welsh –

    I like that when you can you get a person talking to you and not a machine/robot. Call times are also fast, typically if I need to call in my issue is fixed within 20 minutes.

  35. micheal golovanevsky –

    Company is great. Straight forward and to the point with the entire process.

  36. Bobby kohan –

    The quality of their products is unmatched

  37. Justin Gellman –

    Found you guys from a google search. Peptides are fairly priced and I like that theres discount codes sent out periodically as well.

  38. Eli Reinach –

    Peptides are great quality and highest purity I have found.

  39. Cameron Sheron –

    My company has been working with Biotech since the start and we never had any issues with them whatsoever. We highly recommend them. Don’t be scared to contact them to work put potential deals or see if they’d have a discount. Like I previously said, i work for a lab company and we like to place big orders. If you need to request anyone Taylor or Danny would be your best bet!

  40. Nick Jaffe –

    They never fail to amaze me with the quality of their products

  41. James Adam –

    I have bought this product from other suppliers before, but this exceeded all my expectations.

  42. Edwin Marque –

    This product works just as described. Follow the storage directions to a T and they’ll last you a while. Just a suggestion I’d make an extra page explaining how it all works as well. I know when I first started out working with peptides I felt a little lost and had to do a lot of research about it. I saw their blog page and it doesn’t seem to have any directions on that (or I did not find it).

  43. Chris Lopez –

    Nunca volveré a comprar a otros proveedores. Esta es la compañia perfecta

  44. Chase Nelson –

    I never needed a peptide Biotech did not have. They have such a huge range of peptides, it’s crazy

  45. Ciley Kappetta –

    This product improved my research considerably.

  46. Rehan Choudhury –

    I would recommend this to those working with peptides or to anyone interested in conducting high quality research. They are effective and high quality. I also caution anyone storing them to not freeze and thaw them too much, Has happened to me a few times where even the highest and purest quality peptides just get ruined and then you’re left with a useless peptide.

  47. Ricardo Gonzalez –

    Estoy muy satisfecho con mi pedido. Volvere a comprar seguro

  48. Yusuf Bey –

    Five stars from me for sure!

  49. Chris O’Connor –

    I recommended them to all my colleagues. Their peptides are remarkable and they have them in stock more frequently than other places.

  50. Annie Cheng –

    New customer here! I have placed 3 orders so far and they were honoured amazingly, plus they gave me a discount after making my first purchase with them.

  51. Joe Amin –

    I bought this in bulk and everything went smoothly. Products came in one big box rather than in separate boxes and deliveries. They seemed pretty well packages as well and I wasn’t worried about any damages.

  52. Eric Chavez –

    I will be buying again for sure. Products are fantastic

  53. Noam Belkin –

    Blogs are a nice way to understand some of the peptides and what works better with what type of research.

  54. Kevin Harvey –

    Very good product

  55. Travis Crom –

    Acts faster than any other compound of its kind.

  56. Wayne Robinson –

    Unmatched quality, I do see a difference in my work. Also very content with working with them as they fix issues right away and handle it professionally as well.

  57. Chris Anderson –

    Products are consistently great. Feel like they changed their shipping company because I used to get packages with a vial or two broken from transit but it’s been smooth sailing for a while.

  58. Nate Adams –

    Coworkers rave about the peptides from here and after my research I can see why.

  59. Haiwei Luo –

    I usually buy this in bulk and not once I had any problems storing it for a later use. If you do it right it will last a while just like any peptide. But if you store it incorrectly, you’ll be placing more orders than you’d like.

  60. AJ Cardenas –

    The shelf life on this one is amazing if you follow the directions correctly

  61. Jose Costa –

    Los mejores péptidos que he probado seguro

  62. Cal Goldsman –

    Just got my order in!Got it a day before estimated so nice surprise. I was able to start working on my projects earlier as well. I have been shopping here for a few months now and they are one company that sticks to a tight schedule and gets products out as quickly as they come in.

  63. Tony Pipkin –

    I will be buying this product again. It performed beautifully in my research

  64. Aria Hillas –

    Fantastic product, works very well and the purity speaks for itself. Great find and can’t wait to utilize more of Biotech’s peptides.

  65. Peter Stewart –

    A must-try, for sure

  66. Tim Wesler –

    This is my all time favorite product. Versatile and when store correctly lasts a while. That’s how you know the quality is equally as great as well. I will say the prices are fair as well. Not the cheapest but better than some other places.

  67. Eddie Kean –

    I will be buying again for sure

  68. Jon Bechtel –

    Oustanding service and amazing products

  69. Hal Vapnik –

    Everything from quality, purity, customer service and delivery is top notch

  70. Ron Anderson –

    Quite effective. switched to this from AOD 9604 and I definitely made the right choice.

  71. Kris Ornelas –

    My company has switched to BP as a supplier received a month ago and we have not had any issues. We ordered 50 vials of the Frag and received a free Bac water on the house.

Add a review

Related products