Mod GRF 1-29 SPECIFICATIONS
AKA: Modified GRF (1-29)
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.95 g/mol
PubChem: CID 56841945
CAS Number: 863288-34-0
AKA: Thymosin Beta 4
Molecular Formula: C45H55N9O6
Molecular Weight: 817.9 g/mol
PubChem: CID 6918245
CAS Number: 158861-67-7
What is Mod GRF 1-29 & GHRP-2 Blend?
Mod GRF 1-29 is a synthetic peptide analog of Growth Hormone Releasing Hormone (GHRH). It is a modified version of the first twenty-nine amino acids of the naturally occurring GHRH. This modification provides better stability in the body and also evades metabolic clearance. It leads to natural Growth Hormone production in the body and increased levels of IGF-1 (Insulin-Like Growth Factor-1).
GHRP-2 (Growth Hormone Releasing Peptide) is a second-generation GHRP- a type of Growth hormone Secretagogues. Others are GRP-6, ipamorelin, Hexarelin, etc. It increases the levels of Growth Hormone in the body by amplifying the natural Growth Hormone Releasing Hormone signal transduction pathway and suppresses the action of Somatostatin. Studies have shown that GHRP-2 can be used in much higher doses than thought before by the scientist while still preventing the desensitization inherent to the rest of GHRPs. This helps achieve higher effective levels of Growth Hormone in the body. Another benefit of GRHP-2 over GHRP-6 is its decreased appetite-stimulant effect compared to GHRP-6. It also has a lesser effect on gastric motility.
Various analogs of growth hormone have been studied regarding their ability to increase body Growth Hormone. Still, none of them have been proved of significant benefit as they provided only short-term effects. However, the modified GRF is a growth hormone analog that provides a prolonged increase in the peak and basal growth hormone levels.
Like the natural Growth Hormone Release Hormone, this peptide acts by binding to the growth hormone-releasing hormone receptors occurring in the Pituitary gland. This blend works most efficiently if administered synergistically at the same time as the body naturally releases growth hormones.
A negative feedback mechanism by Somatostatin regulates mod GRF’s effect on Growth Hormone release. It prevents unhealthy levels of Growth Hormone secretion in the body and sustains a natural pattern of growth hormone concentration in the body. These two attributes of this combination provide the basis for preventing the usual side effects that accompany the use of artificial Growth Hormone secretagogues.
Mod GRF 1-29 & GHRP-2 Blend Research
GHRP-2 releases a pulse of Growth Hormone. On the other hand, Mod GRF 1-29 releases and amplifies this pulse. This synergy provides double the effect it would have been possible to achieve with either used alone, even in high concentrations.
1. Fat Loss and Gain in Lean Body Mass:
Increasing muscle growth is one of the widely studied uses of Growth Hormone Analogs. Bodybuilders use it to build muscle and lose fat. It increases muscle growth by increasing the size of already present muscle cells and increasing the number of muscle fibers. This is why it can be a key ingredient while building lean body mass.
2. Tissue Repair and Anti-Aging Property:
Most of the age-related changes occurring in the body are due to a progressive decline in the levels of Growth Hormone. This blend naturally increases GH levels that boost cellular repair and reduces cellular damage. It also enhances collagen production and fibroblast proliferation, leading to better wound healing and tissue repair after an injury. In addition, these peptides help prevent and reverse the effects of oxidative stress on various signs of aging.
3. Blood Sugar Level Regulation:
GHRH analogs play a role in blood-glucose-level regulation by enhancing cell survival and cellular proliferation of pancreatic islets in diabetic patients. It upregulates the release of Insulin-Like Growth Factors. Studies have demonstrated a profound increase in islet size and insulin expression in rats with its use.
In addition to the high blood sugar levels in people with diabetes, dyslipidemias also significantly increase the morbidity associated with diabetes. The use of GHRH analogs has indicated a reduction in the triglyceride-rich lipoproteins in the blood.
4. Improvement in Bone Mineral Density:
GHRH analogs, through their Insulin-Like-Growth Factor 1(IGF-1) mediated actions, enhance proliferation, differentiation, and survival of bone-forming cells. This blend improves bone mineral density and mineralization. It also serves a protective role against hormone-induced bone loss, such as that seen in Osteoporosis.
5. Cardioprotective effects:
Various studies have indicated the role of GHRH analogs in promoting the repair of cardiac tissue, improvement in heart Ejection Fraction, and reducing the infarct size following myocardial infarction. Some laboratory studies demonstrated a decrease in infarct size and attenuation of cardiac hypertrophy in mice.
It also protects the myocardial tissue from oxidative stress induced by reactive oxygen species following ischemia. And that is how it can save the vulnerable yet viable cells of the myocardium.
6. Effects on Sleep:
Studies have demonstrated the role of Mod GRF and GHRP-2’s role in helping those who struggle to maintain or fall asleep. If taken before sleeping, it aids in the induction of sleep and increases the vividness of dreams.