Description
CJC-1295 & Ipamorelin Peptide Blend
Ipamorelin is a growth hormone (GH) secretagogue that has been extensively studied in the diverse biological milieu. It is considered by researchers to be one of the most selective secretagogues and is an apparent agonist of the growth hormone/ghrelin secretagogue receptor.[1] This potential selectivity is attributed to the fact that Ipamorelin does not appear, in any way, to affect the secretion of other pituitary hormones. These include prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or Adrenocorticotropic hormone (ACTH). Ipamorelin appears to act via the molecular mimicry of the natural hormone ghrelin, which triggers and stimulates the release of the growth hormone.[2] This whole process may be regulated by a negative feedback mechanism, which may nullify any ancillary impacts of excess GH production. Researchers suggest that Ipamorelin may impact all physiological processes in which ghrelin is active. Based on their observations, researchers have suggested that Ipamorelin may improve bowel movement and gastric function, enhancing the development and repair of muscles, facilitating the release of insulin hormone from the pancreas, and stimulating the growth of bones. In addition to these potentials, Ipamorelin may also be involved in cellular repair and increased collagen production.[3] It has also been hypothesized that the peptide may act to improve cognitive function and sleep cycle regulation.
CJC-1295 (Mod GRF 1-29) is a synthetic analog of a naturally-occurring peptide hormone, somatocrinin. It is also suggested by researchers to potentially promote the release of GH via stimulation of the growth hormone-releasing hormone receptor.[4] They mainly suggest the peptide to induce secretion of the growth hormone in a pulsatile manner. Since this process also appears to be regulated via a negative feedback mechanism, the ancillary impacts typically associated with excessive growth hormone production appear to be avoided. The peptide has also been associated with high selectivity and a potential supportive influence on the development and growth of muscles, lean body mass, bone function, and insulin resistance.[5] Alba et al. reports that “mice [exposed] every 48 and 72h reached higher body weight and length than placebo … animals.” It is suggested to be involved in cellular repair and regeneration processes as well. More specifically, the researchers share that they conducted an additional investigation into the potential of CJC-1295 on a murine model of GHRH gene ablation (GHRHKO) and related growth decline. It was hypothesized that the CJC-1295 group displayed apparently normal body weight and length, which potentially indicates a positive growth response. When evaluating the possible impact of CJC-1295 on bone length and body composition, the femur and tibia length appeared to remain within normal ranges, as well as lean mass and subcutaneous fat mass. Further analysis revealed that CJC-1295 influence potentially led to an increase in total pituitary RNA and GH mRNA levels. This may possibly suggest that the introduction of the peptide may have caused a proliferation of somatotroph cells, which are the natural cells with GH-producing potential in the pituitary gland. The hypothetical presence of these proliferating cells was suggested through immunohistochemistry images. CJC-1295 has also been suggested to support the immune system and cognitive function. Research on animal systems has indicated that combinatorial introduction of CJC-1295 & Ipamorelin blend appear to influence the growth hormone axis through two different pathways.
CJC-1295 (Mod GRF 1-29) Specifications
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.954 g/mol
Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys(Mal)-NH2
Note: DOES NOT CONTAIN DAC
Ipamorelin Specifications
Molecular Formula: C38H49N9O5
Molecular Weight: 711.86 g/mol
Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH2
CJC-1295 & Ipamorelin Blend Research
Ipamorelin Peptide and The Digestive System
Ipamorelin appears to exert a positive action on gastric function by its possible activation of the ghrelin receptors. In one study, the researchers investigated the potential mechanisms involved in the acceleration of gastric emptying by Ipamorelin. Gastric emptying was measured by determining the percentage of total recovered radioactivity remaining in the stomach 15 minutes after intragastric gavage of a specific substance. The scientists commented that abdominal surgery may have caused a delay in gastric emptying, with a notable amount of the meal remaining in the stomach in the vehicle control group. However, Ipamorelin appeared to cause a significant acceleration of gastric emptying compared to the vehicle control group. This suggests that Ipamorelin may have the potential to speed up the process of gastric emptying. The researchers then assessed the potential action of Ipamorelin on the contractility of gastric smooth muscle induced by acetylcholine and electrical field stimulation. The results suggested that abdominal surgery and intestinal manipulation may lead to a marked inhibition of the contractile responses of gastric smooth muscle to acetylcholine and electrical field stimulation. However, this inhibition may have been reversed when Ipamorelin and ghrelin were co-presented. This suggests that Ipamorelin may stimulate gastric contractility and may potentially reverse the inhibitory action caused by the procedures.[6] As a consequence of its potential in digestive functioning, the peptide was hypothesized to increase appetite and weight gain. According to one study, Ipamorelin may have induced an apparent increase, by approximately 15%, in body weight of the research models. It is hypothesized that Ipamorelin potentially increased the weights of fat pads in relation to body weight, which appeared to lead to an increase in relative body fat as quantified by dual energy X-ray absorptiometry (DEXA). Additionally, Ipamorelin appeared to potentially increase the levels of serum leptin, a hormone believed to be involved in regulating energy balance and appetite. Therefore, the researchers posited that food intake may have been increased in the Ipamorelin groups.[7]
CJC-1295 Peptide and the Pituitary Gland
CJC-1295 appears to target the GHRH receptor of pituitary cells, potentially interacting with specific binding sites on the receptor protein. This interaction may lead to changes in the receptor’s structure, initiating a series of molecular events that may activate signal transduction pathways within the target cells. The binding-induced conformational changes may facilitate the activation of G-proteins, which are signaling proteins hypothesized to be found on the intracellular side of the GHRH receptor.[8] Once activated, these G-proteins may stimulate the production of second messengers like cAMP or IP3, which appear to act as secondary signaling molecules, potentially further propagating the signal within the cell. These second messengers, particularly cAMP, may activate protein kinases, enzymes considered responsible for phosphorylating target proteins.[9] Protein kinases appear to play a role in regulating various cellular processes. The activation of protein kinases may lead to the phosphorylation of transcription factors, which are proteins supporting gene expression. Phosphorylated transcription factors may enter the nucleus and potentially modulate the transcription of specific genes that have been associated with growth hormone synthesis and secretion. Overall, the molecular events triggered by the binding of CJC-1295 may result in the fusion of secretory vesicles containing growth hormone with the plasma membrane. This fusion may enable the release of growth hormone outside the pituitary cells, possibly allowing it to exert biological action.[10]
CJC-1295 & Ipamorelin Blend
Ipamorelin appears to work by increasing the basal expression of GH. CJC-1295 may then act upon the higher basal levels of GH to potentially improve the threshold for both high and low GH levels while maintaining the hormone expression cycle. CJC-1295 & Ipamorelin blend may positively influence the body by improving lean body mass, better utilization of insulin, superior muscle development, and overall improved metabolic capabilities. This is suggested by the positive nitrogen balance reported in some studies. In one study, researchers aimed to examine the metabolic potential of Ipamorelin on specific hepatic indicators of alpha-amino-nitrogen conversion during catabolism induced by steroids. The researchers assessed the hepatic capacity for synthesizing urea-N (CUNS), which is a potential indicator of nitrogen metabolism in the liver. They measured the apparent levels of messenger RNA (mRNA) associated with urea cycle enzymes in the liver, evaluated the overall nitrogen balance, and hypothesized the nitrogen contents of various organs. It is suggested that Ipamorelin possibly resulted in a 20% reduction in CUNS when compared to the catabolic state induced by steroids. Additionally, it may have potentially lowered the expression of urea cycle enzymes, restored nitrogen balance, and hypothetically normalized or improved the nitrogen contents in organs.[11] Finally, since these peptides appear to have slightly different pharmacokinetics, their combinational action may have strong impacts. CJC-1295 (when with DAC) appears to possess a longer half-life of about 6-8 days, which would mean a sustained increase in growth hormone levels. Having an apparent shorter half-life, Ipamorelin is likely to produce quick action and be cleared rapidly from the blood. Therefore, the two peptides may be used to provide a rapid onset of action with Ipamorelin and prolonged effects with CJC-1295.
Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.
References
- Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
- Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
- Venkova K, Mann W, Nelson R, Greenwood-Van Meerveld B. Efficacy of ipamorelin, a novel ghrelin mimetic, in a rodent model of postoperative ileus. J Pharmacol Exp Ther. 2009 Jun;329(3):1110-6. doi: 10.1124/jpet.108.149211. Epub 2009 Mar 16. PMID: 19289567.
- Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683.
- Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006 Dec;291(6):E1290-4. doi: 10.1152/ajpendo.00201.2006. Epub 2006 Jul 5. PMID: 16822960.
- Greenwood-Van Meerveld, B., Tyler, K., Mohammadi, E., & Pietra, C. (2012). Efficacy of ipamorelin, a ghrelin mimetic, on gastric dysmotility in a rodent model of postoperative ileus. Journal of experimental pharmacology, 4, 149–155. https://doi.org/10.2147/JEP.S35396
- Lall, S., Tung, L. Y., Ohlsson, C., Jansson, J. O., & Dickson, S. L. (2001). Growth hormone (GH)-independent stimulation of adiposity by GH secretagogues. Biochemical and biophysical research communications, 280(1), 132–138. https://doi.org/10.1006/bbrc.2000.4065
- Martin, B., Lopez de Maturana, R., Brenneman, R., Walent, T., Mattson, M. P., & Maudsley, S. (2005). Class II G protein-coupled receptors and their ligands in neuronal function and protection. Neuromolecular medicine, 7(1-2), 3–36. https://doi.org/10.1385/nmm:7:1-2:003
- Newton, A. C., Bootman, M. D., & Scott, J. D. (2016). Second Messengers. Cold Spring Harbor perspectives in biology, 8(8), a005926. https://doi.org/10.1101/cshperspect.a005926
- Ionescu, M., & Frohman, L. A. (2006). Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog. The Journal of clinical endocrinology and metabolism, 91(12), 4792–4797. https://doi.org/10.1210/jc.2006-1702
- Aagaard, N. K., Grøfte, T., Greisen, J., Malmlöf, K., Johansen, P. B., Grønbaek, H., Ørskov, H., Tygstrup, N., & Vilstrup, H. (2009). Growth hormone and growth hormone secretagogue effects on nitrogen balance and urea synthesis in steroid treated rats. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 19(5), 426–431. https://doi.org/10.1016/j.ghir.2009.01.001
Ledger Cromwell –
blew my expectations
Elsher Grace –
Perfect peptides. I have been looking awhile for a new peptide place and biotech is in my top 5 on the list. The peptides are fantastic for the price.
Sam Solace –
Glad to have found you guys. Was looking for a reliable company that was quick with shipping out peptides and had a reasonable price tag attached to it. Shipping prices are fair and you do get stuff out right as we place the order at times.
Kelly Hansley –
Happy with the product. Their shipping times cannot be beat
Gatlin Poverly –
Reliable from the start
Kylen Cassidy –
A little disappointed that the sales aren’t what I expected them to be like. It seems to be the less popular options and there isn’t a hug difference in price range either. Here and there there some steals but the majority of the time not the biggest money saver.
Jayden Lopez –
10/10 for sure
Avi Jenkins –
Happy with the deals, thanks for the coupon code!
Lois Salmes –
Only been here for a month and am placing my third order already!
King Marley –
I actually had this sent to a lab to have it tested for accuracy and everything checked out. Thanks!
Jose Gonzalez –
great results
Brian McCready –
Quite the lineup of products available here. Never even heard of most of the peptides available and I’ve been buying peptides for a while.
Bin Mukura –
Excited to order more of this, USPS delayed my package but that is the carriers fault. I did reach out to biotech however to notify them and thye let me know if anything came in that was not to my satisfaction to let them know and they would replace it for me free of charge and with overnight shipping.
Vlad Alegrova –
Placed the order in the morning and had my tracking number emailed to me by noon. Happy Customer here
Everly Ryan –
Best in the game! Gotta give them 5 stars
Bailey Maguire –
thanks for the surprise bac water!!
Roshdi Trashela –
I love the selection of products available to order, Im impressed!
Alexis Ogelio –
love the prices! basically 1/5 the price vs compounding phmcs
A. Jimenez –
USPS lost my package initially but customer service was extremely helpful and assisted me without any questions.
Lois Salmes –
I’ve been using biotech peptides research goods and customer service for about a year now and they’re both excellent. In addition, the delivery time is always exceptionally quick. There are also weekly discounts, so it’s well worth the investment. Overall, they’ve exceeded my expectations in every way.
Hannah Eggum –
It was great assistance! One time, I ordered wrong peptides by mistake. I call and fix it right before they shipped it out! phew!1
Casey Homes –
I ordered a few products last month as a test trial for the company. Just as the reviews said Packages came in a timely matter and we nicely packaged.
Felix Stewart –
good price! good quality!
Jerrel Brown –
I always get the best service when i do happen to call. Packages are sent really fast. Had an issue once where a product was broken in transit but they sent another one right away no questions asked.
Loren Brinley –
They are my go-to for Peptides. Always in stock with what we need AND they’re always sending out discounts or promotions! The last one was for St. Pattys (so random) but they sent out a code for me to use for my next 3 purchases! Definitely felt lucky that day
Diego Sanchez –
Nothing broken, came a little late. but good stuff.
Aaron Salem –
Great variety of peptides. I can find whatever I need here. My one critique or suggestion would to possibly bring in more topical kinds?
AJ FOX –
BIOTECH. MY NEW GO TO SERVICE FOR PEPTIDES. DEPENDABLE FAST AND EXCELLENT.
Colt Reece –
There seemed to be a glicth in the system when I was trying to place my order. It kept redirecting to an error page. I had to email a representative and they explained the site was having some issues today. They offered to take the order over email which was nice, but I decided to wait till the next day when everything was up and running to put in an order. It seemed to be a one day problem and order went smooth the next day anyway.
Chris Fazio –
For beging based on the west coast, they shipped it real quick up to New York!
Lance Barry –
Love doing business with them, great company.
Owen Conoway –
Everything came in perfect condition. No vials were broken and all my peptides were there.
Hellen Barrera –
If you buy in bulk this is the place to be! Taylor even sent up my own discount code for mt orders!
Kevin Bryan –
These guys know a lot about peptides. Had some questions about this peptide and Danny was full of information about its storage and uses for my research.
Brock Smyth –
Have not had a bad experince with them and they always send out some great promotions!
Leo Combs –
I work at a lab site and we have been using Biotech as our got to peptide supplier for about a year now. All our scieteist love the purity and quality of the peptides and I love how easy check our and ordering is. If you run into issues deal with Taylor!! They are the best.
Kent Hacoo –
Peptides are great for the price. Biotech is for sure a more affordable place to buy peptides.
Russle Viray –
Great Blend, bought some for a projet of mine and purity checks out.
Tony Rivera –
I just swictehd over to using Peptide from another company to Biotech. So far I can say the service is much better than some other places I have used in the past.
Angelo Mutia –
Found you guys from a google search. I typically buy from somewhere else but you’re the only one I found carrying this blend right now. Shipping was fast, i’d say peptide is almost the same as a lot of places. I did get a 10% off disocunt after so i’ll defineitly be back.
Jodh Garcha –
We had one vial come in a little banged up. I emailed them right away and got a responce within 15 minutes. They took care of it and sent a new one and offered a discount code for the next purchase.
Micheal Metz –
It’s affordble good and clean peptides.
Noel Limone –
great prices, great service. Can’t ask for more.
Gerry J –
Great at restocking peptides quickly
Noah Glaser –
Bac water is of great quality as well!
Gal Kavaler –
Nothing came broken, they even have the red fragile sign on the box that helps make it noticable that its important and could break.
Taylor Allen –
Blend is great, purest I have found so far.
Mason Platt –
Always have it in stock and never too far with a restock if it is out. Most I have waited for one for any product was little less than a week.
Roe Landesmon –
Fast and easy check out process.
Josh Rubin –
Was worried about the heat affecting the peptides but everything came in great condition. I still think they could implement some cooling method with the shipment for extra precaution.
Oded Tzori –
Nice variety of peptides, I saw some new ones they just brought in as well, can’t wait to work with those.
Dante Siordia –
Blogs are updated weekly and help me with figuring out my next research steps.
Matt Malsin –
Thrilled with the service I recieved. I spoke with Danny as there was an issue with my credit card that was on file. It had expired and I had to put in a new one and could not figure out how. Danny was a saint and took care of that for me and made sure I had all my questions answered and concerns handled.
Sarah Distler Distler –
Jamie was great at helping my pick out peptides. I had placed an order earlier and he had emailed me to inform me the product had gone out of stock and they won’t be restocking for a few days. He let me know if an alternative peptide to use!
Kyle Elderman –
The peptides are pure as can be. Service just as good
Walt Summers –
Blend is great, very consistent with the quality
Roger Simmons –
Thanks for the discount code! Got one for my one year anniversary of my first purchase with them!
Andy Wu –
Great help when I was struggeling to get a big order placed. I found their email and Danny was able to help me out!
Aaron Hernandez –
Found the customer service to be good, Have only had to use them once and they handled my issue well.
Alex Nguyen –
I wish they were a bit faster on restocks.
Ash Bonares –
Got the best prices around!
Bo Gibson –
Always get my peptides in on time, have not had an issue in that regard. I did have an issue with their restock times. Seems they are not as quick as they used to be.
Dipo Afolabi –
Like that there is numerous ways to pay! Wish they could bring back Apple Pay!
Cory Odeniyi –
Great variety of products
Daniel Vo –
MOST AFFORDABLE PEPTIDE SUPPLIER!!!
Benny Lee –
Nice selection of peptides! Seeing some blends I have not seen as well!
Edward Yun –
Have had good experience here I’d say 8/10. Wish they had a better way to let me know about new peptides coming in or restocks. Seems like you have to just constantly check in yourself and I don’t have time to check in everyday.
Taj M. –
Love that I have a lot of ways to pay!
ezra Yeoh –
Like that their site has a blog page that has a lot of new information regarding the peptide! Have found myself ordering some peptides i didn’t think of before because of them as well.
Fahad Hussain –
Had to rush my order the day before and got it on time!! Paid a bit extra but they made it happen!
Broda David –
Been very happy with the Peptides here at biotech
Garret Jackson –
Products are pretty good for the price they’re at. I have seen others that could be better but the price here beats out any other peptide resource for sure.
Sam Batra –
The peptides could not be any purer. The price as well can’t be beat.
Geoffrey Pena –
Got my peptides the day after ordering them, very happy with the fast shipping. P.S. I didn’t even pay extra for it!
Terry Garcia –
Blend is awsome!
Adnan Syed –
Packaging was good enough for me. Came in okay, no visible damage and the heat seems to not have effected the products either.
Sina Abedi –
Been with Biotech for over a year now and am very satisfied with their service and their products.I had some questions on how best to store them and also wanted to know how recently they were taken out from the freezer. They were able to get all those questions answered after some intense digging on their part.
Amandip Bangar –
Nice variety of peptides they have here! In the past few months I’ve been purchasing with them I’ve never ran into a moment where the peptide was sold out. Prices are pretty good for the market right now.
Jay McCreary –
Shelf life is great with this blend. Just have to follow the directions, not hard at all.
Peter Ju –
Got some free Bac water! Thanks!!
Johnathan Ruiz –
Loving their peptides and the fast and efficient customer service I received here! They were able to solve my problem in about 40 minutes give or take. I’ve waited on hold for that long at other places before.
Ankit Hirpara –
Thanks for the discount code!
Vince Nguyen –
Taylor is great help. Helped me when I had a few question on thie blend and others. They even set me up with a 10% off code since I was such a frequent customer.
Miguel Betancourt –
Biotech peptides are the best in the game right now. I researched a ton to find somewhere that had high quality peptides for a price that would not break the bank. Took a while but finally found a place that suited that perfectly.
Erick Corona –
Prices are great. Really reasonable compared to some other places. I do think the sale prices are not the best but I’ll take it.
Austin Sugai –
Excited to get my order! Ordered them this morning and already got a confirmation that it’s on the way!
Chris Tran –
Have referred them to many of my peers.I have never been disappointed with the products I have received. They work well and are cost efficient. nicely priced in this terrible market right now.
Binh Ngo –
Comes as advertised. Vials are smaller than I imagined however.
Andrew Mapps –
My peptides came in ruined and not usable due to a delay in shipping AND the heat. E-mailed their customer service and surprisingly got a call back from Jamie. They let me know they can either rush me my order or give me a full refund and I went with a refund.
Robert Mills –
Love Biotech and their service, best trained employees in the peptide business! I feel like they know about the company and the products and can actually help you unlike some other places where they know nothing!!
Jacob Glasgo –
Blog is neat! Very informative
Jay Martinez –
Highly recommend them for any peptide research
Adam Saunders –
Blend is the best I have found out there!I have shopped a few other places and their blend just didn’t work properly. Always something wrong or skewed my research in some way.I also like their return policy’s, they keep to their word.
Ash Romeo –
Shelf life is great with this blend!
Nick Churbock –
Had an issue with my card payment. Got a call from Taylor explaining what was going on and they were able to just get a new card from me. Other places would have just canceled the order, they however reached out!
Joel Upton –
My favorite peptide spot. Always have this blend in stock.
Zach Nguyen –
Best one on the market!I have been working with peptides for a while now and have encountered many different types of Peptides throughout the years. Some claim to be pure, some claimed to be the best quality ever but all were a dud. Biotech’s are really what they advertise and I can say i was pleasantly surprised.
Ethan Legge –
Price is great! Very reasonable.
Tyler Goertz –
My lab only likes to use peptides from Biotech! They are pure and consistent with purity but also get delivered the fastest and safely!
Don Devlin –
Incredible peptides! Wish I had discovered them much earlier than now.
Sam Redus –
Nice doing business with them!
Jasper Ortiz –
Great payment options, I think they used to take Apple pay but don’t anymore. Found that the most handy personally but maybe they’ll bring that option back one day!
Brandyn SantaMaria –
I’ve received great response to emails and fast processing to shipping times from this company.. love that !
NICHOLAS Alex –
This company is the best hands down. Quality products and most importantly quality customer service. The offer zelle payments that is trusted and they answered my emails within 5-10 minutes of sending. I was in constant contact with them through the shipping process and even more details about my product. Taylor is a real MVP with answering all of my questions. 10/10 recommend!!