N-Acetyl Semax (25mg)


N-Acetyl Semax peptides are Synthesized and Lyophilized in the USA.

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N-Acetyl Semax Peptide

N-Acetyl Semax is an acetylated form of the Semax peptide. It consists of a 4 amino acid fragment (Met-Glu-His-Phe) from the chain of melanocortin hormones, such as the adrenocorticotropic hormone (ACTH) and a Pro-Gly-Pro fragment. The acetylation of the peptide into N-Acetyl Semax appears to reduce the affinity of other ions, such as Cu++, to its N-terminus.[1] This ultimately may increase the stability and potency of the peptide.


Molecular Formula: C39H54N10O10S

Molecular Weight: 854.97 g/mol

Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH2

N-Acetyl Semax Research

N-Acetyl Semax and Nootropic Impact
N-Acetyl Semax likely has similar or stronger potential as a nootropic than its unmodified counterpart – Semax. However there are currently only studies investigating the effects of Semax. According to clinical research, Semax may significantly increase memory and attention in healthy but fatigued research models.[2] Subjects who received the compound exhibited over 70% correct answers on their memory test compared to 41% on average for the control group. Another trial also reports that Semax may significantly increase the activation of various parts of the brain, as observed via functional magnetic resonance imaging (MRI). Lebedeva et al. concluded, “A greater volume of the default mode network rostral (medial frontal cortex) subcomponent was detected in the Semax group in comparison with controls. Resting state fMRI confirmed Semax effects on the neuronal network of the brain and demonstrated topography of these effects.” [3]

N-Acetyl Semax and Neurotropic Factors
The suggested neuroprotective action of Semax may stem from its potential to activate and elevate the levels of neurotrophic factors in the brain, such as Brain-Derived Neurotrophic Factor (BDNF). Clinical research suggests that Semax may increase the expression of BDNF, and may also have potential in research models of ischaemic stroke. One study in 110 ischemic stroke subjects who were either at an early or late stage of rehabilitation revealed that control therapy delivered in conjunction with the peptide appeared to lead to a significant increase in the levels of BDNF.[4] Furthermore, the increase in BDNF correlated with improved recovery after the stroke, especially in subjects at an early stage of rehabilitation. Gusev et al. reported that “there was a positive correlation between BDNF plasma levels and Barthel score, as well as a correlation between early rehabilitation and motor performance improvement.” Another trial also reported that Semax might have neuroprotective effects on the optic nerve in subjects with glaucoma.[5] According to the researchers, Semax appeared to indicate certain advantages over traditional neuroprotective approaches for glaucoma.

N-Acetyl Semax and the Digestive System
Semax has also been suggested by researchers to have ulcer mitigating potential. According to a 2002 study published in the Bulletin of Experimental Biology and Medicine, N-Acetyl Semax may be almost 3 times more effective than a placebo in speeding up the healing after a gastric ulcer.[6] 14 days of exposure to Semax appeared to lead to ulcer healing in almost 90% of research models receiving intranasal Semax compared to just over 30% in control group.

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.



  1. Magrì, A., Tabbì, G., Giuffrida, A., Pappalardo, G., Satriano, C., Naletova, I., Nicoletti, V. G., & Attanasio, F. (2016). Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties. Journal of inorganic biochemistry, 164, 59–69. https://doi.org/10.1016/j.jinorgbio.2016.08.013
  2. Kaplan, A. Y. A., Kochetova, A. G., Nezavibathko, V. N., Rjasina, T. V., & Ashmarin, I. P. (1996). Synthetic acth analogue semax displays nootropic‐like activity in humans. Neuroscience Research Communications, 19(2), 115-123.
  3. Lebedeva, I. S., Panikratova, Y. R., Sokolov, O. Y., Kupriyanov, D. A., Rumshiskaya, A. D., Kost, N. V., & Myasoedov, N. F. (2018). Effects of Semax on the Default Mode Network of the Brain. Bulletin of experimental biology and medicine, 165(5), 653–656. https://doi.org/10.1007/s10517-018-4234-3
  4. Gusev, E. I., Martynov, M. Y., Kostenko, E. V., Petrova, L. V., & Bobyreva, S. N. (2018). Éffektivnost’ semaksa pri lechenii bol’nykh na raznykh stadiiakh ishemicheskogo insul’ta [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 118(3. Vyp. 2), 61–68. https://doi.org/10.17116/jnevro20181183261-68
  5. Kurysheva, N. I., Shpak, A. A., Ioĭleva, E. E., Galanter, L. I., Nagornova, N. D., Shubina, N. I.u, & Shlyshalova, N. N. (2001). “Semaks” v lechenii glaukomatoznoĭ opticheskoĭ neĭropatii u bol’nykh s normalizovannym oftal’motonusom [Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone]. Vestnik oftalmologii, 117(4), 5–8.
  6. Ivanikov, I. O., Brekhova, M. E., Samonina, G. E., Myasoedov, N. F., & Ashmarin, I. P. (2002). Therapy of peptic ulcer with semax peptide. Bulletin of experimental biology and medicine, 134(1), 73–74. https://doi.org/10.1023/a:1020621124776
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