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Tesamorelin (10mg)

(27 customer reviews)

$76.00

Tesameorelin peptides are Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity5 - 910 +
Discount5%10%
Price$72.20$68.40
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Tesamorelin-10mg Category:

Description

What is the Tesamorelin Peptide?

Tesamorelin is a chemically altered growth hormone-releasing hormone (GHRH) analog. This peptide is a trans-3-hexanoic acid version of natural GHRH. It has been heavily researched for its potential to enhance peripheral nerve regeneration and improve mild cognitive impairment (MCI), the precursor to dementia. Tesamorelin appears to mediate the positive influence of GHRH and other GHRH analogs such as GRF (1-29)CJC-1295, and sermorelin. The trans-3-hexanoic acid modification may increase its blood plasma stability and half-life. Both Tesamorelin and CJC-1295 appear to maintain the physiological effects of GHRH and display limited side effects compared to other analogs, which typically disrupt the physiological rhythm of GH release.

Specifications

Molecular Formula: C221H366N72O67S

Molecular Weight: 5135.77 g/mol

Sequence: trans-hexenoyl-acid-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-AsnSer-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-LeuGln-Asp-Ile-Met-Ser-Arg-GlnGln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu

PubChem: CID 44147413

CAS Number: 901758-09-6

Reconstitution: Required

Tesamorelin Research

Tesamorelin and Growth Hormone Deficiency, HIV
Highly active antiretroviral therapy (HAART) triggers endocrine and metabolic disorders, including growth hormone (GH) deficiency. The HIV infection alters the pituitary gland function and causes GH deficiency in one-third of HAART patients.[1] Tesamorelin research suggests the peptide may be a safer and more effective treatment for improving GH levels than the administration of exogenous GH, particularly in HIV-positive individuals.

Tesamorelin and Cardiac Disease
Adiposity and antiretroviral drugs put HIV-positive individuals at increased risk of developing cardiovascular disease (CVD). Hence prevention of CVD is of crucial concern in such patients, and statins have been the drug of choice. Tesamorelin studies posit that the peptide reduces lipodystrophy and triglyceride, total cholesterol, and non-HDL-C in HIV-positive patients.[2] Ectopic fat deposition is involved in inflammation, which increases the risk of CVD. Adipose tissue deposition in visceral organs, epicardium, and liver enhance CVD risk. The peptide thus may decrease inflammatory response by controlling excess adiposity.[3] The researchers note that “HIV-infected patients receiving tesamorelin with ≥8% reduction in VAT have significantly improved triglyceride levels, adiponectin levels, and preservation of glucose homeostasis over 52 weeks of treatment.”

Tesamorelin and Lypodystrophy
Tesamorelin is principally researched in relation to treating HIV-associated lipodystrophy caused by a viral infection and the adverse effect of antiretroviral therapy. Patients suffering from lipodystrophy rely on diet, exercise, some ineffective medications, and surgery as a last measure. The peptide appeared to reduce adiposity by about 20% in patients.[4] The researchers also note that “The odds of response of VAT ‹140 cm2 was 3.9 times greater for tesamorelin-treated patients than that of patients receiving placebo.”

Tesamorelin and Peripheral Nerve Damage
Peripheral nerve damage can be caused by injury, diabetes, or surgical interventions. It triggers debilitating motor and sensory function challenges in the affected parts. There is very limited intervention as nerve cells are tough to regenerate. Studies show that growth hormone manipulation can improve peripheral nerve injury and increase both rate and extent of healing.[5] Tesamorelin is being considered for such intervention.

Tesamorelin Investigated in Dementia
GHRH analogs, including Tesamorelin, have been researched for their potential to improve cognitive ability in patients suffering from the early stages of dementia. A randomized, double-blind, placebo-controlled study was conducted with a large cohort over a period of twenty weeks at the University of Washington School of Medicine. The study observed that Tesamorelin and other GHRH analogs may influence dementia by increasing gamma-aminobutyric acid (GABA) in the brain and decreasing myo-insoitol (MI).[6] These findings on the potential of Tesamorelin use in the treatment of dementia also suggest new avenues for research to find a cure. The peptide is a sought-after molecule for clinical trials. It is presently being evaluated for its ability to regulate cardiovascular disease in HIV, enhance healing of peripheral nerves following injury, and slow the progression of dementia. Clinical trials are being conducted in several different areas. Experimental studies report that Tesamorelin appears to exhibit minimal side effects, low oral bioavailability, and excellent subcutaneous bioavailability in mice. The dosage for use in mice (per kg) does not scale to humans. Tesamorelin is sold at Biotech Peptides for educational and scientific research and not for human use.

References

  1. Rochira, V., & Guaraldi, G. (2017). Growth hormone deficiency and human immunodeficiency virus. Best practice & research. Clinical endocrinology & metabolism, 31(1), 91–111. doi:10.1016/j.beem.2017.02.006.
  2. Falutz, J., Allas, S., Blot, K., Potvin, D., Kotler, D., Somero, M., Berger, D., Brown, S., Richmond, G., Fessel, J., Turner, R., & Grinspoon, S. (2007). Metabolic effects of a growth hormone-releasing factor in patients with HIV. The New England journal of medicine, 357(23), 2359–2370. doi:10.1056/NEJMoa072375.
  3. Stanley, T. L., Falutz, J., Marsolais, C., Morin, J., Soulban, G., Mamputu, J. C., Assaad, H., Turner, R., & Grinspoon, S. K. (2012). Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 54(11), 1642–1651. doi:10.1093/cid/cis251.
  4. Mangili, A., Falutz, J., Mamputu, J. C., Stepanians, M., & Hayward, B. (2015). Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat. PloS one, 10(10), e0140358. doi:10.1371/journal.pone.0140358.
  5. Tuffaha, S. H., Singh, P., Budihardjo, J. D., Means, K. R., Higgins, J. P., Shores, J. T., Salvatori, R., Höke, A., Lee, W. P., & Brandacher, G. (2016). Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury. Expert opinion on therapeutic targets, 20(10), 1259–1265. doi:10.1080/14728222.2016.1188079.
  6. Friedman, S. D., Baker, L. D., Borson, S., Jensen, J. E., Barsness, S. M., Craft, S., Merriam, G. R., Otto, R. K., Novotny, E. J., & Vitiello, M. V. (2013). Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging. JAMA neurology, 70(7), 883–890. doi:10.1001/jamaneurol.2013.1425.
All orders ship same day if placed by 2pm PST.
This product is strictly for research/laboratory use only. Human or animal use and/or consumption is strictly prohibited by law. Only qualified and licensed professionals should handle these products. Any information found on Biotech Peptides is strictly for educational purposes only. Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

27 reviews for Tesamorelin (10mg)

  1. Ali Murphy

    Quick, smooth and secure

  2. mia cox

    Never encountered any problems. I am very pleased with this company overall

  3. Harry Gagnon

    Seamless transaction that was so much better than the competition. Thank you

  4. Eden Kelly

    From the descriptions and the variety available to the packaging its apparent this company is highly specialized in this niche field.

  5. Aaron Grant

    The product was exactly as I expected. I am a very satisfied customer as a lot of places are a hit or miss. Biotech comes through every single time with no problems

  6. Oliver Walsh

    Works exactly like the expensive stuff you’d find at a compounding pharmacy but way better deal!

  7. Luna Torres

    This peptide worked well. Results turned out great.

  8. Chee Baisho

    Ecstatic to have found you guys, you’ve made the process a lot easier. thanks for the awesome products

  9. Kenny Yamamoto

    Peptides showed up a few days later than expected so docking some points. Don’t think it was a carrier issue either.

  10. Shea Rain

    Id definitely recommend you guys to friends. Thanks for accepting credit cards! Makes the process so much more convenient.

  11. Mickael Dobre

    really enjoy ordering products from here!Just wish they had bundle deals!

  12. Liza Perkins

    Ill be ordering again, thanks for the freebie!!

  13. Rossina Koshy

    This is litteraly a fifth of the pirce I was paying just a few months ago. Thanks!

  14. Naomi Sarian

    As advertised! Only thing that suprised me was how small the vials actually are. They seem so much bigger in the pictures.

  15. Susan Onuoha

    love the product, this is a must-have in my experiments

  16. Patricia Paiz

    tried alternating between this and other websites but couldn’t seem to find a website that beat the quality of the products here

  17. Nancy George

    Very informative website. I was pleased to see that everything you need to know can easily be found on their page

  18. Eleanor Calder

    I like the fact that they have a lot of peptides. It’s a pretty basic buying procedure, easy for me to use and get around. I like that they’re trying to please me the customer. They offer sales the entire year it seems and had sent me discount codes too. The products seem to be of good quality and vials come in good condition

  19. Maegan Stevenson

    Product is what it is. Purity checks out, had what I needed in stock. Had an issue with payment but they called me right away to fix it. Stress-free transaction.

  20. Leonard Caponegro

    Packaging is great, no breaks or ruined products. Fast delivery, got them the next morning.

  21. Elliot Duffy

    Thanks for take different payment methods! Saves me the frustration of figuring out payment.

  22. kj sharpe

    Everything came on time, no complaints.

  23. christian mosher

    Happy with the service and peptide.

  24. Will Harrison

    Return time is great, quality is even better.

  25. Danny Cho

    Products are fantastic. Purest Peptides on the market. I think they’re in the middle price wise. Not too expensive but no the cheapest around either.

  26. Diego Lopez

    Had to wait a while for the restock. Seems like an issue everywhere but there’t took longer than usual.

  27. Daren Jones

    Waited a bit longer for this restock than other times, kind of disappointed that it took that long.

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