CJC-1295 with DAC Overview

by | Jan 27, 2022 | Research

CJC-1295 is a synthetically modified and tetra-substituted form of growth hormone-releasing hormone (GHRH129). Due to substituting four amino acids from the core unit, the CJC-1295 with DAC peptide is more resistant to cleavage by proteolytic enzymes. CJC-1295 significantly increases plasma growth hormone (GH) and insulin-like growth factor 1 (IGF1) levels in animals and humans. The estimated half-life of this substance is about 6-8 days in humans.

It contains a chain of 30 amino acids, a molecular weight of 3368.7, and a molecular formula of C152H252N44O42. CJC-1295 acts by binding to serum albumin-a, and the addition of the Drug Affinity Complex or DAC prolongs the half-life of CJC-1295 and the duration of action in animal subjects.


Mechanism of Action of CJC-1295 with DAC

Studies of the CJC-1295 with DAC peptide in animal subjects show how this peptide functions by interacting with growth hormone (GH), insulin-like growth factor 1 (IGF1), and the enzyme dipeptidyl aminopeptidase IV (DPPIV) is showing.

DPPIV is an antigenic enzyme involved in signal transduction, apoptosis or programmed cell death, and immune system regulation. It also directly affects the half-life of growth hormone (GH), shortening it to just under 7 minutes.

CJC-1295 with DAC reduces the production of the DPPIV enzyme. This reduction extends the half-life of GH and IGF1 and creates a feedback loop that lasts more than seven days after administration to animal subjects.


CJC-1295 Potential Benefits

The mechanism of action of the CJC-1295 peptide dramatically prolongs the half-life of growth hormone (GH) and insulin-like growth factor 1 (IGF1) and dramatically extends the processes involving GH and IGF1. Some of these effects are below.


Increase in Protein Synthesis. The extended half-life of GH and IGF1 caused by CJC-1295 increases the rate of protein synthesis in experimental animals. This result will significantly increase muscle size and muscle mass over time.


Increase in Bone Density. Increased protein synthesis plays a role in increasing bone density. Experimental animals have shown that bone is rich in minerals per square centimeter after administration of CJC-1295.


Decrease in Body Fat. The effects of CJC-1295 on DPPIV and GHRH have also played an essential role in lipolysis or body fat breakdown. Researchers found that subjects increased lipolysis, reducing their overall body fat.


Improved Quality of Sleep. There is no way to measure the quality of sleep in animals quantitatively. Still, this effect implies that increased deep sleep also compensates for increased protein synthesis rates.

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