Mod GRF 1-29 & Ipamorelin Blend (10mg)

(29 customer reviews)

$81.00

Mod GRF (1-29) & Ipamorelin blend is Synthesized and Lyophilized in the USA.

Discount per Quantity

Quantity 5 - 910 +
Discount 5%10%
Price $76.95$72.90
Orders over $200 receive:
FREE - 30ml bottle of bacteriostatic water
(Required for reconstitution)
FREE - USPS priority shipping
SKU: Mod-GRF-1-29-Ipamorelin-10mg Category:

Description

Modified GRF (1-29) & Ipamorelin Peptide Blend

Modified GRF (1-29) and Ipamorelin are separate peptides, which may work synergistically and have been studied in combination for their potential impact in growth hormone release and growth hormone pulses. This increase may result in several downstream physiological activities associated with increased growth hormone release. Mod GRF (1-29) peptide is an analog of growth hormone-releasing hormone (GHRH).[1] Similarly, Ipamorelin is suggested to act via binding to growth hormone secretagogue receptors.[2] Generally, GRF has a short half-life that limits its research potential. However, GRF (1-29) has a modified structure with an apparent longer half-life and therefore better research potential. Likewise, Ipamorelin appears to have a high sensitivity to growth hormone receptors, leading to superior research conditions. Combination of these peptides may lead to an increase in growth hormone response compared to control levels.

Mod GRF 1-29 Specifications

Molecular Formula: C152H252N44O42

Molecular Weight: 3367.95 g/mol

Sequence: H-Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2

Ipamorelin Specifications

Molecular Formula: C38H49N9O5

Molecular Weight: 711.85 g/mol

Sequence: Aib-His-D-2Nal-D-Phe-Lys-NH2

Mod GRF (1-29) & Ipamorelin Research

Mod GRF (1-29) & Ipamorelin and Gastrointestinal Tract
Research suggests that high circulation of growth hormone may induce positive impact within the gastrointestinal tract, and thereby on inflammatory bowel disease and short bowel syndrome.[3] Researchers report that “65% of [subjects] receiving GH achieved … remission, compared to 20% [given] with CTX alone.” Growth hormone appears to act via Vasoactive Intestinal Peptide (VIP) receptor VIPC1. This interaction may allow the hormone to improve bowel motility.

Mod GRF (1-29) & Ipamorelin and Cardiovascular Function
Myocardial Infarction (MI) is considered to lead to scarring of cardiac tissues and may reduce heart function (such as ejection fraction). Studies in animal models have suggested that growth hormone may accelerate heart tissue repair post-MI, reduce infarct size, improve cardiac ejection fraction, and improve overall cardiac function.[4] The scientists reveal that “Through activation of GHS-R1a, secretagogues produced a positive inotropic effect on ischemic cardiomyocytes and protected them from I/R injury probably by protecting or recovering p-PLB (and therefore SR Ca2+ content) to allow the maintenance or recovery of normal cardiac contractility.”

Mod GRF (1-29) & Ipamorelin and Bone
Research in growth hormone stimulating peptides such as Mod GRF (1-29) and Ipamorelin suggests that these peptides, such as Ipamorelin, when observed in murine models, may potentially completely halt any bone loss triggered by steroids.[5] Moreover, it may potentially trigger new bone formation and increase the Bone Mineral Density (BMD) by up to four-fold.

Mod GRF (1-29) & Ipamorelin and Muscle Cells
Research suggests that growth hormone-secretagogues, of which Ipamorelin is classified, may inhibit the catabolic activity of glucocorticoids on muscles (such as muscle wasting).[6] Mod GRF (1-29) & Ipamorelin peptide combination may have a high growth hormone-receptor sensitivity and act via mechanisms including increased levels of Insulin-Like Growth Factor 1 (IGF-1), leading to muscle cell proliferation.

Mod GRF (1-29) & Ipamorelin and Blood Sugar Regulation
Some research suggests that growth hormone-analogs may increase the number of beta-pancreatic cells, leading to an increase insulin secretion. Calcium-driven channels are considered to mediate insulin secretion from pancreatic cells. Growth hormone-secretagogues such as Ipamorelin may trigger insulin release from pancreatic cells via pancreatic cells’ calcium channels.[7]

Mod GRF (1-29) & Ipamorelin and the Thyroid
Thyroid dysfunction may occur concomitantly with growth hormone disturbances. This is considered often to be the case in conditions involving the pituitary gland, where thyroid dysfunction may be associated with growth hormone deficiency. Researchers have noticed that research models of thyroid insufficiency, when exposed to GRF, appear to exhibit an increase in thyroid support.[9]

Disclaimer: The products mentioned are not intended for human or animal consumption. Research chemicals are intended solely for laboratory experimentation and/or in-vitro testing. Bodily introduction of any sort is strictly prohibited by law. All purchases are limited to licensed researchers and/or qualified professionals. All information shared in this article is for educational purposes only.

 

References

  1. Waelbroeck M, Robberecht P, Coy DH, Camus JC, De Neef P, Christophe J. Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1-29)-NH2 as a VIP antagonist. Endocrinology. 1985 Jun;116(6):2643-9. doi: 10.1210/endo-116-6-2643. PMID: 2859987.
  2. Raun K, Hansen BS, Johansen NL, Thøgersen H, Madsen K, Ankersen M, Andersen PH. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998 Nov;139(5):552-61. doi: 10.1530/eje.0.1390552. PMID: 9849822.
  3. Denson LA, Kim MO, Bezold R, Carey R, Osuntokun B, Nylund C, Willson T, Bonkowski E, Li D, Ballard E, Collins M, Moyer MS, Klein DJ. A randomized controlled trial of growth hormone in active pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2010 Aug;51(2):130-9. doi: 10.1097/MPG.0b013e3181c992d6. PMID: 20453679; PMCID: PMC2910806.
  4. Ma Y, Zhang L, Edwards JN, Launikonis BS, Chen C. Growth hormone secretagogues protect mouse cardiomyocytes from in vitro ischemia/reperfusion injury through regulation of intracellular calcium. PLoS One. 2012;7(4):e35265. doi: 10.1371/journal.pone.0035265. Epub 2012 Apr 6. PMID: 22493744; PMCID: PMC3320867.
  5. Svensson J, Lall S, Dickson SL, Bengtsson BA, Rømer J, Ahnfelt-Rønne I, Ohlsson C, Jansson JO. The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats. J Endocrinol. 2000 Jun;165(3):569-77. doi: 10.1677/joe.0.1650569. PMID: 10828840.
  6. Sinha DK, Balasubramanian A, Tatem AJ, Rivera-Mirabal J, Yu J, Kovac J, Pastuszak AW, Lipshultz LI. Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males. Transl Androl Urol. 2020 Mar;9(Suppl 2):S149-S159. doi: 10.21037/tau.2019.11.30. PMID: 32257855; PMCID: PMC7108996.
  7. Adeghate E, Ponery AS. Mechanism of ipamorelin-evoked insulin release from the pancreas of normal and diabetic rats. Neuro Endocrinol Lett. 2004 Dec;25(6):403-6. PMID: 15665799.
  8. Beck DE, Sweeney WB, McCarter MD; Ipamorelin 201 Study Group. Prospective, randomized, controlled, proof-of-concept study of the Ghrelin mimetic ipamorelin for the management of postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014 Dec;29(12):1527-34. doi: 10.1007/s00384-014-2030-8. Epub 2014 Oct 21. PMID: 25331030.
  9. Valcavi R, Jordan V, Dieguez C, John R, Manicardi E, Portioli I, Rodriguez-Arnao MD, Gomez-Pan A, Hall R, Scanlon MF. Growth hormone responses to GRF 1-29 in patients with primary hypothyroidism before and during replacement therapy with thyroxine. Clin Endocrinol (Oxf). 1986 Jun;24(6):693-8. doi: 10.1111/j.1365-2265.1986.tb01666.x. PMID: 3098458.
All orders ship same day if placed by 12 PST.
This product is strictly for research/laboratory use only.  Human or animal use and/or consumption is strictly prohibited by law.  Only qualified and licensed professionals should handle these products.  Any information found on Biotech Peptides is strictly for educational purposes only.  Refer to our terms and conditions for more details.

Additional information

Brand

Biotech Peptides

29 reviews for Mod GRF 1-29 & Ipamorelin Blend (10mg)

  1. Annie Bardot

    Always a pleasure talking to customer service, Ive had a couple minor issues with USPS but its been resolved by CS with no questions aksed.

  2. Tony West

    After ordering from here several times I’ve had nothing but good experiences.

  3. Axel Langley

    As described, couldn’t have asked for more. Thanks for the freebie <3

  4. Leif McKenna

    I’ve had concerns regarding sanitation with other suppliers but everything came packaged really professionally.

  5. Brantley Daughtler

    love the product

  6. Penny King

    Danny was super helpful and was the one who contacted me when something was wrong with my payment. They made the process easy and just took payment over the phone which was great since I wasn’t near a computer at the moment.

  7. Jonathan Ottensooser

    They went above and beyond to help me. Had a problem with my payment. They reached out by phone to inform me of the problem and handled it right away. The guy even explained to me how to avoid this ordeal the next time I place an order. The best part was I got my order on schedule.

  8. Reece Lam

    This was my first time ordering from Biotech Peptides! Only slightly disappointed that a few products I needed were out. I did see a few others I was running low on so decided to order does instead. Hoping I have a good experience with shipping and quality.

  9. Daniella Navarro

    Siempre es un gran placer comprar aquí.

  10. Taj Khan

    Superior company. No words

  11. Alex Bartram

    No words needed. I’ll let the review speak for itself

  12. Diego Sanchez

    Muy buena compañia

  13. Andre Mac

    Have’t experinced the service you get at Biotech at any other Peptide business.

  14. Harlow Pham

    The delivery time took me by surprise. Cannot believe how fast they work

  15. Laura Perry

    Only thing I have to say is wish they would email or have a waitlist or soemthing to notify me when product is back in stock. Other than that I have no other complinats.

  16. Issac Kim

    I wish I discovered you earlier. Would’ve saved me a lot of bad peptides and experiences

  17. PORTER BLACK

    I suggest them to co-workers when they ask for a peptide source referral.

  18. Elija Stevenson

    This blend is simply the best things I’ve ever come across on this site.

  19. Spencer Noels

    No doubt, the best peptide website on the market. The best products and services available.

  20. Matthew Stahl

    Excellent, 11 out of 10 blend, thanks for making this available.

  21. A. McGill

    Every time I make a call, I receive the greatest service. Shipping is lightning-fast. When a product was damaged in shipping, they immediately replaced it with a new one and didn’t ask any questions.

  22. eric paciello

    I tried a couple peptides from them last month as a test run. No things were damaged or lost in the delivery.

  23. Mac Weissman

    I honestly feel like your prices are a bit too high. I understand the price-quality ratio thing, but some of the scores on here are immense. Might wanna reconsider a bit.

  24. Joey Ablouh

    Nice selection of peptides, prices are fair too

  25. Erick Richardson

    This is how you do business. Astonishing quality and amazing prices!

  26. Jose Lima

    This is the nicest blend I have ever tested out

  27. Jordan Rosales

    Tuve la mejor experiencia con ellos hasta ahora. seguiré comprando

  28. Devin Roberts

    They’re a good place to get peptides from. Peptides are of good quality. Have had no issues with regards to purity. Shipping is the same as everywhere as well nothing too special or different.

  29. Chuck Yates

    Definitely know how to keep your customers coming back. From the best products on the market too well trained employees.

Add a review