What is Mod GRF (1-29) – Ipamorelin Blend?
Mod GRF (1-29) – Ipamorelin are two peptides with similar functions and work synergistically. Together, these peptides trigger growth hormone release and stimulate the growth hormone pulses. This increase results in the physiological benefits associated with increased growth hormone release, such as improved growth, vitality, mental clarity, and overall health.
Mod GRF (1-29) peptide is an analog of growth hormone-releasing hormone (GHRH). Similarly, ipamorelin is capable of binding to growth hormone secretagogue receptors. Generally, GRF has a short half-life that limits its therapeutic potential. However, GRF (1-29) has a modified structure with a longer half-life and better therapeutic potential. Likewise, ipamorelin has a high sensitivity to growth hormone receptors leading to superior therapeutic outcomes. Mixing these peptides into a single blend can lead to a better growth hormone response.
Research suggests that using the blend of Mod GRF (1-29) – Ipamorelin can lead to better outcomes than using either of these peptides alone. These outcomes include improved memory, better glucose control, enhanced post-workout recovery, better lean muscle gain, and improved overall health.
Mod GRF 1-29 SPECIFICATIONS
AKA: Modified GRF (1-29)
Molecular Formula: C152H252N44O42
Molecular Weight: 3367.95 g/mol
PubChem: CID 56841945
CAS Number: 863288-34-0
Molecular Formula: C38H49N9O5
Molecular Weight: 711.85 g/mol
PubChem: CID 9831659
CAS Number: 170851-70-4
Research on Mod GRF (1-29) – Ipamorelin Blend
1. Gastrointestinal Health
Research suggests that GH has positive effects on inflammatory bowel disease (especially Crohn’sCrohn’s disease) and short bowel syndrome. GH acts via Vasoactive Intestinal Peptide (VIP) receptor VIPC1. This interaction allows GH to improve bowel motility and constipation, a major issue in inflammatory bowel disease.
2. Cardiac Health
Myocardial Infarction (MI) leads to the scarring of cardiac tissues and reduces heart function (such as ejection fraction); Studies in animal models have suggested the benefits of GH, stimulating therapies in improving heart health following MI. GH analogs can accelerate heart tissue repair post-MI, reduce infarct size, improve cardiac ejection fraction, and improve overall cardiac health.
3. Bone Health
Issues associated with bone health, such as osteoporosis, are a major public health concern. Therapies such as bisphosphonates, monoclonal antibodies, and hormone therapies are approved methods for treating osteoporosis. These therapies are effective, but serious side effects limit their efficacy. In comparison, GH stimulating peptides such as Mod GRF (1-29) and Ipamorelin are inexpensive therapy to improve bone health with an excellent safety profile. Long term use of corticosteroids is one of the biggest risk factors for accelerated osteoporosis.
Research in animal models suggests that GH-stimulating peptides such as ipamorelin can completely halt the bone loss triggered by steroids. Moreover, it triggers new bone formation and increases the Bone Mineral Density (BMD) by four-folds. This increase in BMD improves bone quality and strength and reduces the risk of osteoporosis complications such as fragility fractures.
4. Muscle Growth
Research suggests that GH-secretagogues like ipamorelin inhibit the catabolic effects of glucocorticoids on muscles (such as muscle wasting). Mod GRF (1-29) – Ipamorelin peptide combination has high GH-receptor sensitivity and acts via mechanisms including increased levels of Insulin-Like Growth Factor 1 (IGF-1), leading to better muscle gain. These abilities of this combination make it a valuable therapeutic target for corticosteroid-induced muscle wasting and can stimulate muscle gain post-workout.
5. Blood Sugar Regulation
Diabetic is a condition involving almost all major organs and body systems. Better blood sugar regulation leads to improved morbidity and mortality associated with diabetes. Mod GRF (1-29) – Ipamorelin blend can lead to better diabetes control in various ways. Some research suggests that using GH-analogs can increase the number of beta-pancreatic cells leading to better insulin secretion. Calcium-driven channels mediate insulin secretion from pancreatic cells. GH-secretagogues such as ipamorelin can trigger insulin release from pancreatic cells by acting on the pancreatic cells’ calcium channels. Therefore, this peptide combination has a huge therapeutic potential for diabetes management.
6. Management of Postoperative Ileus
Postoperative Ileus (POI) is a common complication following intra-abdominal surgeries. This combination can significantly reduce the chances of POI and reduce the time to the first meal by approximately 12 hours.
7. Thyroid Health
Thyroid dysfunction occurs concomitantly with growth hormone disturbances. This is especially true for conditions involving the pituitary gland, where thyroid dysfunction is also associated with GH deficiency. Researchers have noticed that individuals with thyroid insufficiency, when given GRF, show a better response to their thyroid replacement.
8. Mental Health
Mod GRF (1-29) – Ipamorelin peptide combination can immensely affect neurodegenerative conditions and general mental well-being. Research suggests that GH-stimulating therapies can lead to improved neurogenesis and can be a potential therapy for conditions such as dementia and Parkinson’s Disease. In addition, research has also suggested that the use of GH and GH-analogs can improve mental health indicators such as concentration, mental clarity, problem-solving abilities, and etc.